A comparative study on the anti-wrinkle benefits of an active complex (Palmitoyl Tripeptide-38, Silybum marianum fruit extract, Hyaluronic acid (HA), and Chenopodium quinoa seed extract) Comparative Evaluation of the Anti-wrinkle Efficacy of Hyaluronic acid, Peptide, and Some Herbal extracts’ Complex
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Keywords
Anti-wrinkle, active complex, skin moisture, transepidermal water loss, Visioface, Cutometer
Abstract
Background: recently, a wide range of natural polymers and plant extracts have been used to slow down aging and ameliorate the skin by reducing fine lines and wrinkles. Aims: This research investigates the efficacy of hyaluronic acid, palmitoyl tripeptide-38, and two rich herbal extracts in the form of a topical anti-wrinkle cream. Methods: the complex which was formulated using some active ingredients, was applied twice daily for 3 months in a group composed of 30 women, in the crow’s feet region. The improvement of the appearance of wrinkles in that area was assessed by a self-evaluation and the GAIS (Global aesthetic improvement) scale. In addition, the wrinkle depth and volume, skin moisture, and transepidermal water loss (TEWL) were measured using the Visioface, Tewameter, and Cutometer devices at baseline and after 6 and 12 weeks of treatment. Results: there were no noticeable adverse reactions including erythema, irritation, or allergic reactions after the treatment period. Clinical measurements showed an improvement in the subjective evaluation of the skin’s appearance by the GAIS scale in 14 and 17 of the participants in grade 1 of this scale after 6 and 12 weeks of treatment. The wrinkles’ volume and depth were significantly reduced (p<0.05). In addition, the skin’s moisture and gross and net elasticity increased after 12 weeks of treatment (p< 0.05). The skin transepidermal water loss also decreased to -22% after 12 weeks of application (p<0.05). Conclusions: the results of this study revealed that this topical cream, serves as a safe and reliable option for skin hydration and exerts powerful anti-aging benefits compared to the base formula.
References
2. Menon GK, Kligman AM. Barrier functions of human skin: a holistic view. Skin Pharmacol Physiol. 2009; 22(4):178-89.
3. Chaudhary M, Khan A, Gupta M. Skin ageing: Pathophysiology and current market treatment approaches. Curr Aging Sci. 2020; 13(1):22-30.
4. Shin JW, Kwon SH, Choi JY, et al. Molecular mechanisms of dermal aging and antiaging approaches. Int J Mol Sci. 2019; 20(9):2126.
5. Sparr E, Millecamps D, Isoir M, Burnier V, Larsson Å, Cabane B. Controlling the hydration of the skin though the application of occluding barrier creams. J R Soc Interface. 2013; 10(80):20120788.
6. Sjerobabski-Masnec I, Šitum M. Skin aging. Acta Clin Croat. 2010; 49(4):515-8.
7. Mesa-Arango AC, Flórez-Muñoz SV, Sanclemente G. Mechanisms of skin aging. Iatreia. 2017; 30(2):160-70.
8. Gragnani A, Mac Cornick S, Chominski V, de Noronha SM, de Noronha SA, Ferreira LM. Review of major theories of skin aging. Advances in Aging Research. 2014; 2014.
9. Makrantonaki E, Zouboulis CC. Molecular mechanisms of skin aging: state of the art. Ann N Y Acad Sci. 2007; 1119:40-50.
10. Luebberding S, Krueger N, Kerscher M. Age‐related changes in skin barrier function–quantitative evaluation of 150 female subjects. Int J Cosmet Sci. 2013; 35(2):183-90.
11. Tobin DJ. Introduction to skin aging. J Tissue Viability. 2017; 26(1):37-46.
12. Naeimifar A, Ahmad Nasrollahi S, Samadi A, et al. Preparation and evaluation of anti‐wrinkle cream containing saffron extract and avocado oil. J Cosmet Dermatol. 2020; 19(9):2366-73.
13. Glogau RG. Aesthetic and anatomic analysis of the aging skin. Semin Cutan Med Surg. 1996; 15(3):134-138.
14. Savoia A, Onori N, Baldi A. Efficacy of Skinfill plus filler in the management of facial aging: a multicenter, post-marketing clinical study. Biomedical Dermatology. 2018; 2(1):1-6.
15. Rasul A, Akhtar N. Anti-aging potential of a cream containing milk thistle extract: Formulation and in vivo evaluation. African Journal of Biotechnology. 2012; 11(6):1509-15.
16. Menaa F, Badole SL, Menaa B, Menaa A. Promising plant extracts with in vivo anti-melanoma potential. Bioactive Dietary Factors and Plant Extracts in Dermatology. 2013:283-90.
17. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002; 138(11):1462-70.
18. Rattanawiwatpong P, Wanitphakdeedecha R, Bumrungpert A, Maiprasert M. Anti‐aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: a split‐face, randomized controlled trial. J Cosmet Dermatol. 2020; 19(3):671-6.
19. Schagen SK. Topical peptide treatments with effective anti-aging results. Cosmetics. 2017; 4(2):16.
20. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012; 4(3):253-8.
21. Bae SM, Ahn YH, Jung JK, Hwang JG. A Study on the Skin Anti-wrinkle Effect of Novel Palmitoyl Tripeptide. Journal of the Society of Cosmetic Scientists of Korea. 2010; 36(1):65-9.
22. Pavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol. 2011; 10(9):990-1000.
23. Fisher GJ, Talwar HS, Lin J, et al. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest. 1998; 101(6):1432-40.
24. Vostálová J, Tinková E, Biedermann D, Kosina P, Ulrichová J, Rajnochová Svobodová A. Skin protective activity of silymarin and its flavonolignans. Molecules. 2019; 24(6):1022.
25. Camillo-Andrade AC, Santos MD, Fischer JS, et al. Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue. Sci Rep. 2020; 10(1):19392.
26. Joshi A, Kale S, Chandel S, Pal DK. Likert scale: Explored and explained. British journal of applied science & technology. 2015; 7(4):396-403.
27. Sano H, Hokazono Y, Ogawa R. Distensibility and gross elasticity of the skin at various body sites and association with pathological scarring: a case study. J Clin Aesthet Dermatol. 2018; 11(6):15-18.
28. Qiraouani Boucetta K, Charrouf Z, Aguenaou H, Derouiche A, Bensouda Y. The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity. Clin Interv Aging. 2015:339-49.
29. Froschle M, Plüss R, Bojarski K, Peter A. Antiaging effect with cosmotropic substances. SÖFW-journal. 2004; 130(4):36-43.
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Ehsan Eslahi, Mahloran Cosmetic Company
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