All ptomaines fault! : The strange story of the cadaveric alkaloids, from forensic medicine to molecular biology passing through the asylum.

All ptomaines fault!

The strange story of the cadaveric alkaloids, from forensic medicine to molecular biology passing through the asylum.

Authors

  • Francesca Donato a:1:{s:5:"en_US";s:16:"Fondazione CErPS";}
  • Rossella Greco Fondazione CErPS (Research centre psychiatry and human sciences)
  • Carlotta Carpentieri Fondazione CErPS (Research centre psychiatry and human sciences)
  • Benedetta Pittore Fondazione CErPS (Research centre psychiatry and human sciences)
  • Carmela D'Orlando Fondazione CErPS (Research centre psychiatry and human sciences)
  • Annalidia Donato University "Magna Graecia" of Catanzaro
  • Natalia Malara University "Magna Graecia" of Catanzaro
  • Giuseppe Donato University "Magna Graecia" of Catanzaro

Keywords:

Ptomaines, Francesco Selmi, Biogenic amines, Asylum, Raffaele Canger, Molecular biology, toxins

Abstract

This essay attempts to reconstruct the story of ptomaines, discovered in 1872 by the Italian chemist Francesco Selmi. This work provides a brief summary of this story, focusing also on an emblematic clinical study by the end of the 19th century, written by Raffaele Canger, a doctor who worked in the Asylum of Nocera Inferiore in Italy.

The main thesis of Canger's paper is that the transient neuropsychiatric symptoms, which can occur during influenza or other infectious diseases, are due to a toxic delirium caused by the direct action of ptomaines on the brain with subsequent restitutio ad integrum.

The importance of the discovery of ptomaines was discredited for a very long time, but recently, with the contribute of molecular biology it was established again the role of these molecules in human pathology.

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Published

06-05-2022

Issue

Section

Review articles: History of Medicine

How to Cite

1.
Donato F, Greco R, Carpentieri C, Pittore B, D'Orlando C, Donato A, et al. All ptomaines fault! : The strange story of the cadaveric alkaloids, from forensic medicine to molecular biology passing through the asylum. Med Histor [Internet]. 2022 May 6 [cited 2025 Mar. 15];6(1):e2022009. Available from: https://mattioli1885journals.com/index.php/MedHistor/article/view/12795

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