Phobia and Fear of COVID-19: origins, complications and management, a narrative review
Keywords:
Corona phobia, Fear, Anxiety, Nosophobia, Social PanicAbstract
Introduction. The outbreak of Coronavirus Disease 2019 (COVID-19) have changed into a global crisis. Psychologically, this process of alteration can lead to feelings of fear, insecurity, and anxiety. This fear and anxiety can be caused by a variety of factors. However, due to the lack of extensive studies at this time, there are little data on these conditions related to COVID-19. Therefore, in this narrative review, we have tried to identify the most important possible causes of anxiety and fear due to this disease, based on logical shreds of evidence. Then we tried to discuss the consequences and ways to manage and prevent them.
Methods. The current focus was on three major axes of corona-phobia, fear and anxiety. PubMed, Science Direct, Scopus, Google Scholar and authoritative news and information sources were considered as the data sources.
Results. Findings from the analysis of the results revealed that, in addition to the real and the logical reasons which belong to the intrinsic properties of SARS-CoV-2, some misleadings and misconceptions induced by media, governmental policies, public awareness level, and non-scientific speculations and contradictory data expressed by experts, researchers and scientific societies, could provide the way for the development of corona-phobia, and fear.
Conclusions. Each of these causal components, in its place, leads to some degrees of psychological disorders and subsequent consequences and complications. Finally, here we reviewed, summarized the previous research findings on how to prevent and manage this type of psychological disorder, and made comparisons.
References
1. Brown RS, Lees-Haley PR. Fear of future illness, chemical AIDS, and cancerphobia: a review. Psychol Rep 1992; 71(1): 187-207. doi: 10.2466/ pr0.1992.71.1.187.
2. Mirzaei R, Karampoor S, Sholeh M, Moradi P, Ranjbar R, Ghasemi F. A contemporary review on pathogenesis and immunity of COVID-19 infection. Mol Biol Rep 2020; 47(7): 5365-76. doi: 10.1007/s11033-020-05621-1. Epub 2020 Jun 29.
3. Maduka IC, Neboh EE, Ufelle SA. The relationship between serum cortisol, adrenaline, blood glucose and lipid profile of undergraduate students under examination stress. Afr Health Sci 2015; 15(1): 131-6. doi: 10.4314/ahs.v15i1.18.
4. Johansen JP, Cain CK, Ostroff LE, LeDoux JE. Molecular mechanisms of fear learning and memory. Cell 2011; 147(3): 509-24. doi:
10.1016/j.cell.2011.10.009.
5. Jolad S, Liu W, Schmittmann B, Zia R. Epidemic spreading on preferred degree adaptive networks. PloS One 2012; 7(11): e48686. doi: 10.1371/journal.pone.0048686.
6. Fassino S, Amianto F, Sobrero C, Abbate Daga
G. Panminerva Med 2013; 55(4): 397-413.
7. Asmundson GJG, Taylor S. Coronaphobia: Fear and the 2019-nCoV outbreak. J Anxiety Disord 2020; 70: 102196. doi: 10.1016/j. janxdis.2020.102196.
8. Wang C, Pan R, Wan X, et al. Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Int J Environ Res Public Health 2020; 17(15): 1729. doi: 10.3390/ ijerph17051729.
9. Ren S-Y, Gao R-D, Chen Y-L. Fear can be more harmful than the severe acute respiratory syndrome coronavirus 2 in controlling the corona virus disease 2019 epidemic. World J Clin Cases 2020; 8(4): 652-7. doi: 10.12998/wjcc.v8.i4.652.
10. Shigemura J, Ursano RJ, Morganstein JC, Kurosawa M, Benedek DM. Public responses to the novel 2019 coronavirus (2019-nCoV) in Japan: Mental health consequences and target populations. Psychiatry Clin Neurosci 2020; 74(4): 281-2. doi: 10.1111/pcn.12988.
11. Mirzaie A, Halaji M, Safarpoor Dehkordi F, Ranjbar R, Noorbazargan H. A narrative literature review on traditional medicine options for treatment of corona virus disease 2019 (COVID-19). Complement Ther Clin Pract 2020; 40: 101214. doi.org/10.1016/j.ctcp.2020.101214.
12. Mohammadzadeh Rostami F, Nasr Esfahani B, Ahadi AM, Shalibeik S. A Review of Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Iran J Med Microbiol 2020; 14(2): 154-61.
13. Fisher D, Heymann D. Q&A: The novel coronavirus outbreak causing COVID-19. BMC Med 2020; 18(1): 57. doi: 10.1186/s12916-020-01533-w.
14. Wu JT, Leung K, Leung GM. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. Lancet 2020; 395(10225): 689-97. doi: 10.1016/ S0140-6736(20)30260-9.
15. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229): 1054-62. doi: 10.1016/S0140-6736(20)30566-3.
16. Mohammadpour S, Torshizi Esfahani A, Halaji M, Lak M, Ranjbar R. An updated review of the association of host genetic factors with susceptibility and resistance to COVID-19. J Cell Physiol 2020; 236(1): 49-54. doi.org/10.1002/jcp.29868. Epub 2020 Jun 15.
17. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China. N Engl J Med 2020; 382(18): 1708-20. doi: 10.1056/NEJMoa2002032. Epub. 2020 Feb 28.
18. World Health Organization (WHO). Coronavirus disease 2019 (COVID-19): situation report, 67. WHO, 2020.
19. Miri SM, Roozbeh F, Omranirad A, Alavian SM. Panic of Buying Toilet Papers: A Historical Memory or a Horrible Truth? Systematic Review of Gastrointestinal Manifestations of COVID19. Hepat Monit 20(3): 102729. doi: 10.5812/ hepatmon.102729.
20. Halaji M, Farahani A, Ranjbar R, Heiat M, Safarpoor Dehkordi F, Emerging Coronaviruses: First SARS, Second MERS and Third SARS-CoV-2: Epidemiological Updates of COVID-19. Infez Med 2020; 28(1): 6-17.
21. Tian Y, Rong L, Nian W, He Y. Gastrointestinal features in COVID‐19 and the possibility of faecal transmission. Aliment Pharmacol Ther 2020; 51(9): 843-851. doi: 10.1111/apt.15731.
22. Wong SH, Lui RN, Sung JJ. Covid‐19 and the Digestive System. J Gastroenterol Hepatol 2020; 35(5): 744-8. doi: 10.1111/jgh.15047.
23. Kotfis K, Skonieczna-Żydecka K. COVID-19: gastrointestinal symptoms and potential sources of 2019-nCoV transmission. Anaesthesiol Intensive Ther 2020; 52(2): 171-24. doi: 10.5114/ ait.2020.93867.
24. Sheikhshahrokh A, Ranjbar R, Saeidi E, et al. Frontier Therapeutics and Vaccine Strategies for SARS-CoV-2 (COVID-19): a Review. Iran J Public Health 2020; 49: 18-29.
25. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA 2020; 323(11): 1061-9. doi: 10.1001/jama.2020.1585.
26. Bagheri SHR, Asghari AM, Farhadi M, et al. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak. Med J Islam Repub Iran 2020; 34: 62. doi: 10.34171/mjiri.34.62.
27. Joob B, Wiwanitkit V. COVID-19 can present with a rash and be mistaken for Dengue. J Am Acad Dermatol 2020; 82(5): e177. doi: 10.1016/j.jaad.2020.03.036. Epub 2020 Mar 22.
28. Paraskevis D, Kostaki EG, Magiorkinis G, Panayiotakopoulos G, Sourvinos G, Tsiodras S. Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombina-
tion event. Infect Genet Evol 2020; 79: 104212. doi: 10.1016/j.meegid.2020.104212. Epub 2020 Jan 29.
29. Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak. Curr Biol 2020; 30(8): 1578. doi: 10.1016/j.cub.2020.03.063.
30. Shi J, Wen Z, Zhong G, et al. Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2. Science 2020; 368(6494): 1016-20. doi: 10.1126/science. abb7015. Epub 2020 Apr 8.
31. Torabi R, Ranjbar R, Halaji M, Heiat M. Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.
Mol Cell Probes 2020; 101636. doi: 10.1016/j. mcp.2020.101636. Epub 2020 Jul 14.
32. Campbell D, Topping A, Barr C. Virus patients more likely to die may have ventilators taken away. 2020 Apr 1. Available on: https://www.theguardian.com/society/2020/apr/01/ventilatorsmay-be-taken-from-stable-coronavirus-patientsfor-healthier-ones-bma-says [Last accessed: 2021 Mar 11].
33. Hawryluck L, Gold WL, Robinson S, Pogorski S, Galea S, Styra R. SARS control and psychological effects of quarantine, Toronto, Canada. Emerg Infect Dis 2004; 10(7): 1206-12. doi: 10.3201/eid1007.030703.
34. Reynolds D, Garay J, Deamond S, Moran M, Gold W, Styra R. Understanding, compliance and psychological impact of the SARS quarantine experience. Epidemiol Infect 2008; 136(7): 997-1007. doi: 10.1017/S0950268807009156.
35. Barbisch D, Koenig KL, Shih F-Y. Is there a case for quarantine? Perspectives from SARS to Ebola. Disaster Med Public Health Prep 2015; 9(5): 547-53. doi: 10.1017/dmp.2015.38.
36. Cherutich P, Kaiser R, Galbraith J, et al. Lack of knowledge of HIV status a major barrier to HIV prevention, care and treatment efforts in Kenya: results from a nationally representative study. PloS One 2012; 7(5): e36797. doi: 10.1371/ journal.pone.0036797.
37. Olalekan A. From a single case to epidemics: Fear and misconceptions mitigating against effective control of Ebola virus disease outbreak in South-Western Nigeria. Niger J Health Sci 2015; 15(1): 58-9. doi: 10.4103/1596-4078.171382.
38. Ali I. The COVID-19 Pandemic: Making Sense of Rumor and Fear: Op-Ed. Med Anthropol 2020: 39(5): 376-9.doi: 10.1080/01459740.2020.1745481.
Epub 2020 Mar 26.
39. Zhao S, Lin Q, Ran J, et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int J Infect Dis 2020; 92: 214-7. doi: 10.1016/j.ijid.2020.01.050.
40. Froum S. Do NSAIDs exacerbate coronavirus severity: Myth or reality? Mar 31st, 2020. Available on: https://www.perioimplantadvisory.com/ periodontics/oral-medicine-anesthetics-and-oralsystemic-connection/article/14173105/do-nsaidsexacerbate-coronavirus-covid19-severity-mythor-reality [Last accessed: 2021, Mar 11].
41. Zhang L, Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol 2020; 92(5): 479-90. doi: 10.1002/ jmv.25707.
42. Feng S, Shen C, Xia N, Song W, Fan M, Cowling BJ. Rational use of face masks in the COVID-19 pandemic. Lancet Respir Med 2020; 8(5): 434-6.
doi: 10.1016/S2213-2600(20)30134-X.
43. Wong J, Goh QY, Tan Z, et al. Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore. Can J Anaesth 2020; 67(6): 732-45. doi: 10.1007/s12630-02001620-9.
44. Leung CC, Lam TH, Cheng KK. Mass masking in the COVID-19 epidemic: people need guidance. Lancet 2020; 395(10228): 945. doi: 10.1016/ S0140-6736(20)30520-1. Epub 2020 Mar 3.
45. National Public Radio (2020 Feb 4). Poll: Most Americans say U.S. “doing enough” to prevent coronavirus spread. Available on: https://www. npr.org/sections/healthshots/2020/02/04/802 387025/poll-most-americans-say-u-s-doingenough-toprevent-coronavirus-spread [Last accessed: 2021, Mar 11].
46. Lima CKT, Carvalho PMM, Lima I, et al. The emotional impact of Coronavirus 2019nCoV (new Coronavirus disease). Psychiatry Res 2020; 287: 112915. doi: 10.1016/j. psychres.2020.112915. Epub 2020 Mar 12.
47. Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395(10227): 912-20. doi: 10.1016/S01406736(20)30460-8.
48. Jeong H, Yim HW, Song Y-J, et al. Mental health status of people isolated due to Middle East Respiratory Syndrome. Epidemiol Health 2016; 38: e2016048. doi: 10.4178/epih.e2016048.
49. Mihashi M, Otsubo Y, Yinjuan X, Nagatomi K, Hoshiko M, Ishitake T. Predictive factorsof psychological disorder development during recovery following SARS outbreak. Health Psychol 2009; 28(1): 91-100. doi: 10.1037/a0013674.
50. Desclaux A, Badji D, Ndione AG, Sow K. Accepted monitoring or endured quarantine? Ebola contacts’ perceptions in Senegal. Soc Sci Med 2017; 178: 38-45. doi: 10.1016/j. socscimed.2017.02.009.
51. McEwen BS. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol 2008; 583(2): 17485. doi: 10.1016/j.ejphar.2007.11.071.
52. Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005; 5(6): 243-51. doi: 10.1038/ nri1571.
53. Park S-C, Park YC. Mental health care measures in response to the 2019 novel coronavirus outbreak in Korea. Psychiatry Investig 2020; 17(2): 85-6. doi: 10.30773/pi.2020.0058.
54. Hasannejad-Bibalan M, Hekmatnezhad H. A light shining through darkness: probiotic against COVID-19. J Curr Biomed Rep 2020; 1(1): 1-2.
55. Zhong B-L, Luo W, Hai-Mei Li, et al. Knowledge, attitudes, and practices towards COVID-19 among Chinese residents during the rapid rise period of the COVID-19 outbreak: a quick online cross-sectional survey. Int J Biol Sci 2020; 16(10): 1745-52. doi: 10.7150/ijbs.45221.
56. Balkhy HH, Abolfotouh MA, Al-Hathlool RH, Al-Jumah MA. Awareness, attitudes, and practices related to the swine influenza pandemic among the Saudi public. BMC Infect Dis 2010; 10: 42. doi: 10.1186/1471-2334-10-42.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.