Could the human papillomavirus recombinant vaccine be a new valid approach in the management of ano-genital warts?

Could the human papillomavirus recombinant vaccine be a new valid approach in the management of ano-genital warts?

Authors

  • A. Sarro
  • C. Airoldi
  • A. Pedicini
  • E. Di Tullio
  • A. Pecere

Keywords:

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Abstract

In line with previous case-reports, the study conducted by Hoom Choi ascertained the effectiveness of the HPV vaccine as a promising approach in the therapeutic management of ano-genital warts. The uncertain length of time and the varying effectiveness of traditional treatments encourage a reduction in the use of them and the development of a therapeutic use of HPV-vaccination. While the efficacy, safety profile and effects of the HPV vaccination in preventing ano-genital warts is well-know, therapeutic HPV vaccination has not been evaluated in a Randomized Prospective Trial, to date, and has not received a formal approval and an off-label indication for the treatment of those lesions. For these reasons, RCTs or cohort studies are warranted.

References

1. Choi H. Can quadrivalent human papillomavirus prophylactic vaccine be an effective alternative for the therapeutic management of genital warts? an exploratory study. Int Braz J Urol. 2019 Mar-Apr; 45(2):

361-8. doi: 10.1590/S1677-5538.IBJU.2018.0355.

2. Lee HJ, Kim JK, Kim DH, Yoon MS. Condyloma acuminatum treated with recombinant quadrivalent human papillomavirus vaccine (types 6, 11, 16, 18). J Am Acad Dermatol. 2011 Jun; 64(6): e130-2. doi: 10.1016/j.jaad.2010.12.032.

3. Venugopal SS, Murrell DF. Recalcitrant cutaneous warts treated with recombinant quadrivalent human papillomavirus vaccine (t6, 11, 16, and 18) in a developmentally delayed, 31-year-old white nan. Arch Dermatol. 2010 May; 146(5): 475-7. doi: 10.1001/archdermatol.2010.71.

4. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003 Jan; 16(1): 1-17. doi:

10.1128/CMR.16.1.1-17.2003.

5. Garland SM, Kjaer SK, Muñoz N, et al. Impact and effectiveness of the quadrivalent human papillomavirus vaccine: A Systematic review of 10 years of Real-world Experience. Clin Infect Dis. 2016 Aug 15; 63(4): 519-27. doi: 10.1093/cid/ciw354. Epub 2016 May 26.

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Published

2025-09-04

Issue

Section

Letter to the Editor

How to Cite

1.
Sarro A, Airoldi C, Pedicini A, Di Tullio E, Pecere A. Could the human papillomavirus recombinant vaccine be a new valid approach in the management of ano-genital warts?. Ann Ig. 2025;34(6):656-658. doi:10.7416/ai.2021.2496