Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis?

Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis?

Authors

  • Eda Burcu Boerner Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, University Duisburg-Essen
  • Ulrich Costabel Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, University Duisburg-Essen
  • Thomas Ernst Wessendorf Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, University Duisburg-Essen
  • Dirk Theegarten Institute of Pathology, Ruhrlandklinik, University Hospital Essen
  • Martin Hetzel Krankenhaus vom Roten Kreuz, Department of Pneumology, Stuttgart
  • Marjolein Drent Department of Toxicology, Faculty of Health,Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
  • Francesco Bonella Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, University Duisburg-Essen

Keywords:

Pulmonary alveolar proteinosis (PAP), sarcoidosis, whole lung lavage

Abstract

Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of surfactant phospholipids and lipoproteins within the alveoli.  Here we report on a female patient who was diagnosed with autoimmune PAP and successfully treated with whole lung lavage (WLL). 15 months after PAP diagnosis the patient developed marked fatigue. Additional tests revealed the diagnosis of sarcoidosis. We can only speculate that PAP and sarcoidosis in our patient are linked to each other based on the fact that other autoimmune disorders have also been associated with sarcoidosis.

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Published

29-03-2016

Issue

Vol. 33 No. 1 (2016)

Section

Case Reports

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Boerner EB, Costabel U, Wessendorf TE, Theegarten D, Hetzel M, Drent M, et al. Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis?. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2016 Mar. 29 [cited 2025 Mar. 20];33(1):90-4. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/4247