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6 minute walk test in assessing severity of interstitial lung disease: an observational study

6MWT in assessing severity of ILD

Authors

  • Zhanwei Hu Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034.
  • Li Gao Department of Medical Imaging, Peking University First Hospital, Beijing 100034.
  • Qing Yu Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034.
  • Zhe Jin Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034.
  • Juhong Liu Department of General Medicine, Desheng Community Healthcare Center, Xicheng District, Beijing 100120.
  • Yuanyuan Lian Department of General Medicine, Shichahai Community Healthcare Center, Xicheng District, Beijing 100034.
  • Chengli Que Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034.

DOI:

https://doi.org/10.36141/svdld.v40i2.13991

Keywords:

interstitial lung disease; pulmonary function test; quantitative CT; 6 minute walk test

Abstract

BACKGROUND: 6 minute walk test (6MWT) is a potential tool in assessing severity of interstitial lung disease (ILD).

OBJECTIVES: To explore the relationship between 6MWT and traditional measures including pulmonary function and chest CT. To determine factors that may influence the 6 minute walk distance (6MWD).

METHODS: 73 patients with ILD were enrolled in the clinic of Peking University First Hospital. 6MWTs, pulmonary CTs and pulmonary function tests were performed and their correlations were analyzed. Multivariate regression analysis was used to determine factors that may impact 6MWD.

RESULTS: 30 (41.4%) of the 73 patients were female, the mean age was 66.1 ±9.6 years. 102 follow-up visits were completed. 6MWD and decrease of SpO2 were both correlated with FEV1, FVC, TLC and DLCO. The volume of normal lung area calculated by the quantitative CT software was positively correlated with 6MWD (r = 0.309, P < 0.01) and negatively correlated with decrease of SpO2 (r = -0.272, P < 0.01). Based on the backward multivariate model ( F = 10.537, P < 0.001, adjusted R2 = 0.509 ), 6MWD was predicted by age, height, body weight, baseline SpO2, increase of heart rate, FEV1, DLCO and FVC.

CONCLUSIONS: The results of 6MWTs were closely correlated with pulmonary function and quantitative CT in patients with ILD . However, aside from disease severity, 6MWD was influenced by personal characteristics and the degree of patient effort, which should be considered by clinicians interpreting 6WMT results.

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Original Articles: Clinical Research