This is a preview and has not been published.

Vascular tree-in-bud sign in Pulmonary Tumour Thrombotic Microangiopathy (PTTM): CT findings for a difficult radiological early antemortem diagnosis

Authors

  • Diletta Cozzi Department of Emergency Radiology, Careggi University Hospital, Florence, Italy https://orcid.org/0000-0001-7028-9047
  • Giulia Zantonelli Department of Emergency Radiology, Careggi University Hospital, Florence, Italy
  • Alessandra Bindi Department of Emergency Radiology, Careggi University Hospital, Florence, Italy
  • Edoardo Cavigli Department of Emergency Radiology, Careggi University Hospital, Florence, Italy
  • Chiara Moroni Department of Emergency Radiology, Careggi University Hospital, Florence, Italy
  • Filippo Pieralli Intermediate Care Unit, Careggi University Hospital, Florence, Italy
  • Caterina Fattorini Department of Human Pathology and Oncology, Careggi University Hospital, Florence, Italy
  • Vittorio Miele Department of Emergency Radiology, Careggi University Hospital, Florence, Italy
  • Maurizio Bartolucci Department of Radiology, Azienda USL Toscana Centro, Santo Stefano Hospital, Prato, Italy

DOI:

https://doi.org/10.36141/svdld.v40i1.13378

Keywords:

Thrombotic Microangiopathy, Pulmonary Hypertension, Neoplasm, Embolism

Abstract

.

Downloads

Download data is not yet available.

References

A. von Herbay, A. Illes, R. Waldherr, and H. F. Otto, “Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension,” Cancer, vol. 66, no. 3, pp. 587–592, Aug. 1990, doi: 10.1002/1097-0142(19900801)66:3<587::AID-CNCR2820660330>3.0.CO;2-J.

E. Gainza et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Medicine, vol. 93, no. 24, pp. 359–363, Nov. 2014, doi: 10.1097/MD.0000000000000219.

S. McAnearney and M. Drain, “A case of pulmonary tumour thrombotic microangiopathy,” Respiratory Medicine Case Reports, vol. 16, pp. 7–10, 2015, doi: 10.1016/j.rmcr.2015.04.006.

K. Chinen, Y. Tokuda, M. Fujiwara, and Y. Fujioka, “Pulmonary tumor thrombotic microangiopathy in patients with gastric carcinoma: An analysis of 6 autopsy cases and review of the literature,” Pathology - Research and Practice, vol. 206, no. 10, pp. 682–689, Oct. 2010, doi: 10.1016/j.prp.2010.05.002.

D. Katayama et al., “Pulmonary tumor thrombotic microangiopathy caused by prostate carcinoma,” Acta Radiologica Open, vol. 5, no. 8, p. 205846011666230, Aug. 2016, doi: 10.1177/2058460116662300.

R. Godbole, A. Ghatol, J. Betancourt, J. Sacoolidge, and N. Kamangar, “Pulmonary Tumor Thrombotic Microangiopathy: Clinical, Radiologic, and Histologic Correlation,” Journal of Clinical Imaging Science, vol. 5, p. 44, Jul. 2015, doi: 10.4103/2156-7514.161978.

T. Franquet, A. Giménez, R. Prats, J. M. Rodríguez-Arias, and C. Rodríguez, “Thrombotic Microangiopathy of Pulmonary Tumors: A Vascular Cause of Tree-In-Bud Pattern on CT,” American Journal of Roentgenology, vol. 179, no. 4, pp. 897–899, Oct. 2002, doi: 10.2214/ajr.179.4.1790897.

I. C. BRILL, “SUBACUTE COR PULMONALE,” Archives of Internal Medicine, vol. 60, no. 6, p. 1043, Dec. 1937, doi: 10.1001/archinte.1937.00180060096010.

S. Miyano et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Journal of Clinical Oncology, vol. 25, no. 5, pp. 597–599, Feb. 2007, doi: 10.1200/JCO.2006.09.0670.

E. Pena, C. Dennie, T. Franquet, and C. Milroy, “Nonthrombotic Pulmonary Embolism: A Radiological Perspective,” Seminars in Ultrasound, CT and MRI, vol. 33, no. 6, pp. 522–534, Dec. 2012, doi: 10.1053/j.sult.2012.05.002.

R. W. SCHRINER, J. H. RYU, and W. D. EDWARDS, “Microscopic Pulmonary Tumor Embolism Causing Subacute Cor Pulmonale: A Difficult Antemortem Diagnosis,” Mayo Clinic Proceedings, vol. 66, no. 2, pp. 143–148, Feb. 1991, doi: 10.1016/S0025-6196(12)60485-6.

T. Abe et al., “A Case of Recurrent Breast Cancer Identified by Pulmonary Tumor Thrombotic Microangiopathy,” Case Reports in Oncology, vol. 10, no. 2, pp. 620–626, Jul. 2017, doi: 10.1159/000477842.

K. Bae, W.-J. Kwon, S. H. Choi, J. H. Lee, and H. J. Cha, “A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm,” Korean Journal of Radiology, vol. 16, no. 4, p. 936, 2015, doi: 10.3348/kjr.2015.16.4.936.

N. Sakashita, C. Yokose, K. Fujii, M. Matsumoto, K. Ohnishi, and M. Takeya, “Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach,” Pathology International, vol. 57, no. 6, pp. 383–387, Jun. 2007, doi: 10.1111/j.1440-1827.2007.02111.x.

J. K. Pinckard and M. R. Wick, “Tumor-related thrombotic pulmonary microangiopathy: Review of pathologic findings and pathophysiologic mechanisms,” Annals of Diagnostic Pathology, vol. 4, no. 3, pp. 154–157, Jun. 2000, doi: 10.1016/S1092-9134(00)90038-8.

E. T. Sadimin, A. G. Collier, J. W. Gaffney, and B. Fyfe, “Pulmonary Tumor Thrombotic Microangiopathy with Cor Pulmonale due to Desmoplastic Small Round Cell Tumor,” The Journal of Pediatrics, vol. 160, no. 4, pp. 697–699, Apr. 2012, doi: 10.1016/j.jpeds.2011.12.010.

H. Toyonaga et al., “Pulmonary Tumor Thrombotic Microangiopathy Caused by a Parotid Tumor: Early Antemortem Diagnosis and Long-term Survival,” Internal Medicine, vol. 56, no. 1, pp. 67–71, 2017, doi: 10.2169/internalmedicine.56.7439.

J. A. Shepard, E. H. Moore, P. A. Templeton, and T. C. McLoud, “Pulmonary intravascular tumor emboli: dilated and beaded peripheral pulmonary arteries at CT.,” Radiology, vol. 187, no. 3, pp. 797–801, Jun. 1993, doi: 10.1148/radiology.187.3.8497633.

C. K. Chan, M. A. Hutcheon, R. H. Hyland, G. J. Smith, B. J. Patterson, and R. A. Matthay, “Pulmonary tumor embolism: a critical review of clinical, imaging, and hemodynamic features.,” J Thorac Imaging, vol. 2, no. 4, pp. 4–14, Oct. 1987.

H. Uruga et al., “Pulmonary Tumor Thrombotic Microangiopathy: A Clinical Analysis of 30 Autopsy Cases,” Internal Medicine, vol. 52, no. 12, pp. 1317–1323, 2013, doi: 10.2169/internalmedicine.52.9472.

Y. Tashima et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Clinical Nuclear Medicine, vol. 34, no. 3, pp. 175–177, Mar. 2009, doi: 10.1097/RLU.0b013e3181966f5c.

D. Tack, M.-C. Nollevaux, and P. A. Gevenois, “Tree-in-Bud Pattern in Neoplastic Pulmonary Emboli,” American Journal of Roentgenology, vol. 176, no. 6, pp. 1421–1422, Jun. 2001, doi: 10.2214/ajr.176.6.1761421.

D. Han et al., “Thrombotic and Nonthrombotic Pulmonary Arterial Embolism: Spectrum of Imaging Findings,” RadioGraphics, vol. 23, no. 6, pp. 1521–1539, Nov. 2003, doi: 10.1148/rg.1103035043.

S. E. Rossi, T. Franquet, M. Volpacchio, A. Giménez, and G. Aguilar, “Tree-in-Bud Pattern at Thin-Section CT of the Lungs: Radiologic-Pathologic Overview,” RadioGraphics, vol. 25, no. 3, pp. 789–801, May 2005, doi: 10.1148/rg.253045115.

J. Collins, D. Blankenbaker, and E. J. Stern, “CT patterns of bronchiolar disease: what is ‘tree-in-bud’?,” American Journal of Roentgenology, vol. 171, no. 2, pp. 365–370, Aug. 1998, doi: 10.2214/ajr.171.2.9694453.

G. Dalpiaz and A. Cancellieri, Eds., Atlas of Diffuse Lung Diseases. Cham: Springer International Publishing, 2017. doi: 10.1007/978-3-319-42752-2.

B. v. Patel et al., “Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations,” American Journal of Respiratory and Critical Care Medicine, vol. 202, no. 5, pp. 690–699, Sep. 2020, doi: 10.1164/rccm.202004-1412OC.

G. Dalpiaz et al., “Clinical implications of microvascular CT scan signs in COVID-19 patients requiring invasive mechanical ventilation,” La radiologia medica, vol. 127, no. 2, pp. 162–173, Feb. 2022, doi: 10.1007/s11547-021-01444-7.

N. Gosset, A. A. Bankier, and R. L. Eisenberg, “Tree-In-Bud Pattern,” American Journal of Roentgenology, vol. 193, no. 6, pp. W472–W477, Dec. 2009, doi: 10.2214/AJR.09.3401.

H. Kayatani et al., “Pulmonary Tumor Thrombotic Microangiopathy Diagnosed Antemortem and Treated with Combination Chemotherapy,” Internal Medicine, vol. 51, no. 19, pp. 2767–2770, 2012, doi: 10.2169/internalmedicine.51.7682.

A. Kitamura et al., “A Case of Pulmonary Tumor Thrombotic Microangiopathy Diagnosed by Transbronchial Lung Biopsy and Treated with Chemotherapy and Long-Term Oxygen and Anticoagulation Therapies,” Case Reports in Pulmonology, vol. 2013, pp. 1–3, 2013, doi: 10.1155/2013/259080.

K. Higo, K. Kubota, A. Takeda, M. Higashi, and M. Ohishi, “Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy,” Internal Medicine, vol. 53, no. 22, pp. 2595–2599, 2014, doi: 10.2169/internalmedicine.53.2379.

K. Kubota, T. Shinozaki, Y. Imai, and K. Kario, “Imatinib dramatically alleviates pulmonary tumour thrombotic microangiopathy induced by gastric cancer,” BMJ Case Reports, p. bcr-2017-221032, Sep. 2017, doi: 10.1136/bcr-2017-221032.

I. Fukada et al., “Imatinib Alleviated Pulmonary Hypertension Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient With Metastatic Breast Cancer,” Clinical Breast Cancer, vol. 15, no. 2, pp. e167–e170, Apr. 2015, doi: 10.1016/j.clbc.2014.10.008.

Downloads

Issue

Section

Letter to Editor

Most read articles by the same author(s)