Circulatory TGF- β1 is significantly higher in early stage of pulmonary sarcoidosis

Mehdi Mirsaeidi; Hesham R Omar; Andrew Calzadilla; Ahmad El khatib; Philip Whitney; Nadera Sweiss; Daniel Culver; Michael Campos; Robert Baughman; Roberto Machado

doi:10.36141/svdld.v35i3.6112

Circulatory TGF- β1 is significantly higher in early stage of pulmonary sarcoidosis

Authors

Mehdi Mirsaeidi Division of Pulmonary and Critical Care, University of Miami
Hesham R Omar Internal Medicine Department, Mercy Medical Center, Iowa, USA
Andrew Calzadilla Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA
Ahmad El khatib Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA
Philip Whitney Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA
Nadera Sweiss Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, IL, USA
Daniel Culver Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA
Michael Campos Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA
Robert Baughman Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Cincinnati, OH, USA
Roberto Machado Internal Medicine Department, Mercy Medical Center, Iowa, USA

Abstract

Introduction: The pathogenesis of pulmonary fibrosis in sarcoidosis is not known. We hypothesized that higher levels of circulatory growth factors are present in early stages of pulmonary sarcoidosis and may be associated with pulmonary fibrosis. Methods: Age and sex-matched subjects with sarcoidosis stage 0-1 (n=18), stage 4-5 (n=13) and healthy controls (n=5) had their serum TGF-β1, FGF, and VEGF levels measured as well as their gene expressions determined in peripheral blood mononuclear cells. Results: TGF-β1 levels were significantly higher in patients with stage 0-1 sarcoidosis compared with normal healthy control patients (25,488 vs. 13800 pg/ml, P=0.05). Patients with sarcoidosis stage 4 had a 1.3-fold higher peripheral blood mononuclear cells (PBMC) gene expression of TGF-β1 compared with subjects at stage 0-1 (P= 0.041). The serum levels of FGF, and VEGF had a trend towards higher levels in sarcoidosis subjects compared to normal controls. Conclusion: These results suggest that cell growth factors levels are high in early stages of sarcoidosis. These findings should be validated in larger studies.

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Published

15-10-2018

Issue

Vol. 35 No. 3 (2018)

Section

Original Articles: Clinical Research

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

Mirsaeidi M, Omar HR, Calzadilla A, El khatib A, Whitney P, Sweiss N, et al. Circulatory TGF- β1 is significantly higher in early stage of pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2018 Oct. 15 [cited 2025 Apr. 30];35(3):213-7. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/6112

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