Vascular tree-in-bud sign in Pulmonary Tumour Thrombotic Microangiopathy (PTTM): CT findings for a difficult radiological early antemortem diagnosis
Main Article Content
Keywords
Thrombotic Microangiopathy, Pulmonary Hypertension, Neoplasm, Embolism
Abstract
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References
[1] A. von Herbay, A. Illes, R. Waldherr, and H. F. Otto, “Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension,” Cancer, vol. 66, no. 3, pp. 587–592, Aug. 1990, doi: 10.1002/1097-0142(19900801)66:3<587::AID-CNCR2820660330>3.0.CO;2-J.
[2] E. Gainza et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Medicine, vol. 93, no. 24, pp. 359–363, Nov. 2014, doi: 10.1097/MD.0000000000000219.
[3] S. McAnearney and M. Drain, “A case of pulmonary tumour thrombotic microangiopathy,” Respiratory Medicine Case Reports, vol. 16, pp. 7–10, 2015, doi: 10.1016/j.rmcr.2015.04.006.
[4] K. Chinen, Y. Tokuda, M. Fujiwara, and Y. Fujioka, “Pulmonary tumor thrombotic microangiopathy in patients with gastric carcinoma: An analysis of 6 autopsy cases and review of the literature,” Pathology - Research and Practice, vol. 206, no. 10, pp. 682–689, Oct. 2010, doi: 10.1016/j.prp.2010.05.002.
[5] D. Katayama et al., “Pulmonary tumor thrombotic microangiopathy caused by prostate carcinoma,” Acta Radiologica Open, vol. 5, no. 8, p. 205846011666230, Aug. 2016, doi: 10.1177/2058460116662300.
[6] R. Godbole, A. Ghatol, J. Betancourt, J. Sacoolidge, and N. Kamangar, “Pulmonary Tumor Thrombotic Microangiopathy: Clinical, Radiologic, and Histologic Correlation,” Journal of Clinical Imaging Science, vol. 5, p. 44, Jul. 2015, doi: 10.4103/2156-7514.161978.
[7] T. Franquet, A. Giménez, R. Prats, J. M. Rodríguez-Arias, and C. Rodríguez, “Thrombotic Microangiopathy of Pulmonary Tumors: A Vascular Cause of Tree-In-Bud Pattern on CT,” American Journal of Roentgenology, vol. 179, no. 4, pp. 897–899, Oct. 2002, doi: 10.2214/ajr.179.4.1790897.
[8] I. C. BRILL, “SUBACUTE COR PULMONALE,” Archives of Internal Medicine, vol. 60, no. 6, p. 1043, Dec. 1937, doi: 10.1001/archinte.1937.00180060096010.
[9] S. Miyano et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Journal of Clinical Oncology, vol. 25, no. 5, pp. 597–599, Feb. 2007, doi: 10.1200/JCO.2006.09.0670.
[10] E. Pena, C. Dennie, T. Franquet, and C. Milroy, “Nonthrombotic Pulmonary Embolism: A Radiological Perspective,” Seminars in Ultrasound, CT and MRI, vol. 33, no. 6, pp. 522–534, Dec. 2012, doi: 10.1053/j.sult.2012.05.002.
[11] R. W. SCHRINER, J. H. RYU, and W. D. EDWARDS, “Microscopic Pulmonary Tumor Embolism Causing Subacute Cor Pulmonale: A Difficult Antemortem Diagnosis,” Mayo Clinic Proceedings, vol. 66, no. 2, pp. 143–148, Feb. 1991, doi: 10.1016/S0025-6196(12)60485-6.
[12] T. Abe et al., “A Case of Recurrent Breast Cancer Identified by Pulmonary Tumor Thrombotic Microangiopathy,” Case Reports in Oncology, vol. 10, no. 2, pp. 620–626, Jul. 2017, doi: 10.1159/000477842.
[13] K. Bae, W.-J. Kwon, S. H. Choi, J. H. Lee, and H. J. Cha, “A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm,” Korean Journal of Radiology, vol. 16, no. 4, p. 936, 2015, doi: 10.3348/kjr.2015.16.4.936.
[14] N. Sakashita, C. Yokose, K. Fujii, M. Matsumoto, K. Ohnishi, and M. Takeya, “Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach,” Pathology International, vol. 57, no. 6, pp. 383–387, Jun. 2007, doi: 10.1111/j.1440-1827.2007.02111.x.
[15] J. K. Pinckard and M. R. Wick, “Tumor-related thrombotic pulmonary microangiopathy: Review of pathologic findings and pathophysiologic mechanisms,” Annals of Diagnostic Pathology, vol. 4, no. 3, pp. 154–157, Jun. 2000, doi: 10.1016/S1092-9134(00)90038-8.
[16] E. T. Sadimin, A. G. Collier, J. W. Gaffney, and B. Fyfe, “Pulmonary Tumor Thrombotic Microangiopathy with Cor Pulmonale due to Desmoplastic Small Round Cell Tumor,” The Journal of Pediatrics, vol. 160, no. 4, pp. 697–699, Apr. 2012, doi: 10.1016/j.jpeds.2011.12.010.
[17] H. Toyonaga et al., “Pulmonary Tumor Thrombotic Microangiopathy Caused by a Parotid Tumor: Early Antemortem Diagnosis and Long-term Survival,” Internal Medicine, vol. 56, no. 1, pp. 67–71, 2017, doi: 10.2169/internalmedicine.56.7439.
[18] J. A. Shepard, E. H. Moore, P. A. Templeton, and T. C. McLoud, “Pulmonary intravascular tumor emboli: dilated and beaded peripheral pulmonary arteries at CT.,” Radiology, vol. 187, no. 3, pp. 797–801, Jun. 1993, doi: 10.1148/radiology.187.3.8497633.
[19] C. K. Chan, M. A. Hutcheon, R. H. Hyland, G. J. Smith, B. J. Patterson, and R. A. Matthay, “Pulmonary tumor embolism: a critical review of clinical, imaging, and hemodynamic features.,” J Thorac Imaging, vol. 2, no. 4, pp. 4–14, Oct. 1987.
[20] H. Uruga et al., “Pulmonary Tumor Thrombotic Microangiopathy: A Clinical Analysis of 30 Autopsy Cases,” Internal Medicine, vol. 52, no. 12, pp. 1317–1323, 2013, doi: 10.2169/internalmedicine.52.9472.
[21] Y. Tashima et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Clinical Nuclear Medicine, vol. 34, no. 3, pp. 175–177, Mar. 2009, doi: 10.1097/RLU.0b013e3181966f5c.
[22] D. Tack, M.-C. Nollevaux, and P. A. Gevenois, “Tree-in-Bud Pattern in Neoplastic Pulmonary Emboli,” American Journal of Roentgenology, vol. 176, no. 6, pp. 1421–1422, Jun. 2001, doi: 10.2214/ajr.176.6.1761421.
[23] D. Han et al., “Thrombotic and Nonthrombotic Pulmonary Arterial Embolism: Spectrum of Imaging Findings,” RadioGraphics, vol. 23, no. 6, pp. 1521–1539, Nov. 2003, doi: 10.1148/rg.1103035043.
[24] S. E. Rossi, T. Franquet, M. Volpacchio, A. Giménez, and G. Aguilar, “Tree-in-Bud Pattern at Thin-Section CT of the Lungs: Radiologic-Pathologic Overview,” RadioGraphics, vol. 25, no. 3, pp. 789–801, May 2005, doi: 10.1148/rg.253045115.
[25] J. Collins, D. Blankenbaker, and E. J. Stern, “CT patterns of bronchiolar disease: what is ‘tree-in-bud’?,” American Journal of Roentgenology, vol. 171, no. 2, pp. 365–370, Aug. 1998, doi: 10.2214/ajr.171.2.9694453.
[26] G. Dalpiaz and A. Cancellieri, Eds., Atlas of Diffuse Lung Diseases. Cham: Springer International Publishing, 2017. doi: 10.1007/978-3-319-42752-2.
[27] B. v. Patel et al., “Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations,” American Journal of Respiratory and Critical Care Medicine, vol. 202, no. 5, pp. 690–699, Sep. 2020, doi: 10.1164/rccm.202004-1412OC.
[28] G. Dalpiaz et al., “Clinical implications of microvascular CT scan signs in COVID-19 patients requiring invasive mechanical ventilation,” La radiologia medica, vol. 127, no. 2, pp. 162–173, Feb. 2022, doi: 10.1007/s11547-021-01444-7.
[29] N. Gosset, A. A. Bankier, and R. L. Eisenberg, “Tree-In-Bud Pattern,” American Journal of Roentgenology, vol. 193, no. 6, pp. W472–W477, Dec. 2009, doi: 10.2214/AJR.09.3401.
[30] H. Kayatani et al., “Pulmonary Tumor Thrombotic Microangiopathy Diagnosed Antemortem and Treated with Combination Chemotherapy,” Internal Medicine, vol. 51, no. 19, pp. 2767–2770, 2012, doi: 10.2169/internalmedicine.51.7682.
[31] A. Kitamura et al., “A Case of Pulmonary Tumor Thrombotic Microangiopathy Diagnosed by Transbronchial Lung Biopsy and Treated with Chemotherapy and Long-Term Oxygen and Anticoagulation Therapies,” Case Reports in Pulmonology, vol. 2013, pp. 1–3, 2013, doi: 10.1155/2013/259080.
[32] K. Higo, K. Kubota, A. Takeda, M. Higashi, and M. Ohishi, “Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy,” Internal Medicine, vol. 53, no. 22, pp. 2595–2599, 2014, doi: 10.2169/internalmedicine.53.2379.
[33] K. Kubota, T. Shinozaki, Y. Imai, and K. Kario, “Imatinib dramatically alleviates pulmonary tumour thrombotic microangiopathy induced by gastric cancer,” BMJ Case Reports, p. bcr-2017-221032, Sep. 2017, doi: 10.1136/bcr-2017-221032.
[34] I. Fukada et al., “Imatinib Alleviated Pulmonary Hypertension Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient With Metastatic Breast Cancer,” Clinical Breast Cancer, vol. 15, no. 2, pp. e167–e170, Apr. 2015, doi: 10.1016/j.clbc.2014.10.008.
[2] E. Gainza et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Medicine, vol. 93, no. 24, pp. 359–363, Nov. 2014, doi: 10.1097/MD.0000000000000219.
[3] S. McAnearney and M. Drain, “A case of pulmonary tumour thrombotic microangiopathy,” Respiratory Medicine Case Reports, vol. 16, pp. 7–10, 2015, doi: 10.1016/j.rmcr.2015.04.006.
[4] K. Chinen, Y. Tokuda, M. Fujiwara, and Y. Fujioka, “Pulmonary tumor thrombotic microangiopathy in patients with gastric carcinoma: An analysis of 6 autopsy cases and review of the literature,” Pathology - Research and Practice, vol. 206, no. 10, pp. 682–689, Oct. 2010, doi: 10.1016/j.prp.2010.05.002.
[5] D. Katayama et al., “Pulmonary tumor thrombotic microangiopathy caused by prostate carcinoma,” Acta Radiologica Open, vol. 5, no. 8, p. 205846011666230, Aug. 2016, doi: 10.1177/2058460116662300.
[6] R. Godbole, A. Ghatol, J. Betancourt, J. Sacoolidge, and N. Kamangar, “Pulmonary Tumor Thrombotic Microangiopathy: Clinical, Radiologic, and Histologic Correlation,” Journal of Clinical Imaging Science, vol. 5, p. 44, Jul. 2015, doi: 10.4103/2156-7514.161978.
[7] T. Franquet, A. Giménez, R. Prats, J. M. Rodríguez-Arias, and C. Rodríguez, “Thrombotic Microangiopathy of Pulmonary Tumors: A Vascular Cause of Tree-In-Bud Pattern on CT,” American Journal of Roentgenology, vol. 179, no. 4, pp. 897–899, Oct. 2002, doi: 10.2214/ajr.179.4.1790897.
[8] I. C. BRILL, “SUBACUTE COR PULMONALE,” Archives of Internal Medicine, vol. 60, no. 6, p. 1043, Dec. 1937, doi: 10.1001/archinte.1937.00180060096010.
[9] S. Miyano et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Journal of Clinical Oncology, vol. 25, no. 5, pp. 597–599, Feb. 2007, doi: 10.1200/JCO.2006.09.0670.
[10] E. Pena, C. Dennie, T. Franquet, and C. Milroy, “Nonthrombotic Pulmonary Embolism: A Radiological Perspective,” Seminars in Ultrasound, CT and MRI, vol. 33, no. 6, pp. 522–534, Dec. 2012, doi: 10.1053/j.sult.2012.05.002.
[11] R. W. SCHRINER, J. H. RYU, and W. D. EDWARDS, “Microscopic Pulmonary Tumor Embolism Causing Subacute Cor Pulmonale: A Difficult Antemortem Diagnosis,” Mayo Clinic Proceedings, vol. 66, no. 2, pp. 143–148, Feb. 1991, doi: 10.1016/S0025-6196(12)60485-6.
[12] T. Abe et al., “A Case of Recurrent Breast Cancer Identified by Pulmonary Tumor Thrombotic Microangiopathy,” Case Reports in Oncology, vol. 10, no. 2, pp. 620–626, Jul. 2017, doi: 10.1159/000477842.
[13] K. Bae, W.-J. Kwon, S. H. Choi, J. H. Lee, and H. J. Cha, “A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm,” Korean Journal of Radiology, vol. 16, no. 4, p. 936, 2015, doi: 10.3348/kjr.2015.16.4.936.
[14] N. Sakashita, C. Yokose, K. Fujii, M. Matsumoto, K. Ohnishi, and M. Takeya, “Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach,” Pathology International, vol. 57, no. 6, pp. 383–387, Jun. 2007, doi: 10.1111/j.1440-1827.2007.02111.x.
[15] J. K. Pinckard and M. R. Wick, “Tumor-related thrombotic pulmonary microangiopathy: Review of pathologic findings and pathophysiologic mechanisms,” Annals of Diagnostic Pathology, vol. 4, no. 3, pp. 154–157, Jun. 2000, doi: 10.1016/S1092-9134(00)90038-8.
[16] E. T. Sadimin, A. G. Collier, J. W. Gaffney, and B. Fyfe, “Pulmonary Tumor Thrombotic Microangiopathy with Cor Pulmonale due to Desmoplastic Small Round Cell Tumor,” The Journal of Pediatrics, vol. 160, no. 4, pp. 697–699, Apr. 2012, doi: 10.1016/j.jpeds.2011.12.010.
[17] H. Toyonaga et al., “Pulmonary Tumor Thrombotic Microangiopathy Caused by a Parotid Tumor: Early Antemortem Diagnosis and Long-term Survival,” Internal Medicine, vol. 56, no. 1, pp. 67–71, 2017, doi: 10.2169/internalmedicine.56.7439.
[18] J. A. Shepard, E. H. Moore, P. A. Templeton, and T. C. McLoud, “Pulmonary intravascular tumor emboli: dilated and beaded peripheral pulmonary arteries at CT.,” Radiology, vol. 187, no. 3, pp. 797–801, Jun. 1993, doi: 10.1148/radiology.187.3.8497633.
[19] C. K. Chan, M. A. Hutcheon, R. H. Hyland, G. J. Smith, B. J. Patterson, and R. A. Matthay, “Pulmonary tumor embolism: a critical review of clinical, imaging, and hemodynamic features.,” J Thorac Imaging, vol. 2, no. 4, pp. 4–14, Oct. 1987.
[20] H. Uruga et al., “Pulmonary Tumor Thrombotic Microangiopathy: A Clinical Analysis of 30 Autopsy Cases,” Internal Medicine, vol. 52, no. 12, pp. 1317–1323, 2013, doi: 10.2169/internalmedicine.52.9472.
[21] Y. Tashima et al., “Pulmonary Tumor Thrombotic Microangiopathy,” Clinical Nuclear Medicine, vol. 34, no. 3, pp. 175–177, Mar. 2009, doi: 10.1097/RLU.0b013e3181966f5c.
[22] D. Tack, M.-C. Nollevaux, and P. A. Gevenois, “Tree-in-Bud Pattern in Neoplastic Pulmonary Emboli,” American Journal of Roentgenology, vol. 176, no. 6, pp. 1421–1422, Jun. 2001, doi: 10.2214/ajr.176.6.1761421.
[23] D. Han et al., “Thrombotic and Nonthrombotic Pulmonary Arterial Embolism: Spectrum of Imaging Findings,” RadioGraphics, vol. 23, no. 6, pp. 1521–1539, Nov. 2003, doi: 10.1148/rg.1103035043.
[24] S. E. Rossi, T. Franquet, M. Volpacchio, A. Giménez, and G. Aguilar, “Tree-in-Bud Pattern at Thin-Section CT of the Lungs: Radiologic-Pathologic Overview,” RadioGraphics, vol. 25, no. 3, pp. 789–801, May 2005, doi: 10.1148/rg.253045115.
[25] J. Collins, D. Blankenbaker, and E. J. Stern, “CT patterns of bronchiolar disease: what is ‘tree-in-bud’?,” American Journal of Roentgenology, vol. 171, no. 2, pp. 365–370, Aug. 1998, doi: 10.2214/ajr.171.2.9694453.
[26] G. Dalpiaz and A. Cancellieri, Eds., Atlas of Diffuse Lung Diseases. Cham: Springer International Publishing, 2017. doi: 10.1007/978-3-319-42752-2.
[27] B. v. Patel et al., “Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations,” American Journal of Respiratory and Critical Care Medicine, vol. 202, no. 5, pp. 690–699, Sep. 2020, doi: 10.1164/rccm.202004-1412OC.
[28] G. Dalpiaz et al., “Clinical implications of microvascular CT scan signs in COVID-19 patients requiring invasive mechanical ventilation,” La radiologia medica, vol. 127, no. 2, pp. 162–173, Feb. 2022, doi: 10.1007/s11547-021-01444-7.
[29] N. Gosset, A. A. Bankier, and R. L. Eisenberg, “Tree-In-Bud Pattern,” American Journal of Roentgenology, vol. 193, no. 6, pp. W472–W477, Dec. 2009, doi: 10.2214/AJR.09.3401.
[30] H. Kayatani et al., “Pulmonary Tumor Thrombotic Microangiopathy Diagnosed Antemortem and Treated with Combination Chemotherapy,” Internal Medicine, vol. 51, no. 19, pp. 2767–2770, 2012, doi: 10.2169/internalmedicine.51.7682.
[31] A. Kitamura et al., “A Case of Pulmonary Tumor Thrombotic Microangiopathy Diagnosed by Transbronchial Lung Biopsy and Treated with Chemotherapy and Long-Term Oxygen and Anticoagulation Therapies,” Case Reports in Pulmonology, vol. 2013, pp. 1–3, 2013, doi: 10.1155/2013/259080.
[32] K. Higo, K. Kubota, A. Takeda, M. Higashi, and M. Ohishi, “Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy,” Internal Medicine, vol. 53, no. 22, pp. 2595–2599, 2014, doi: 10.2169/internalmedicine.53.2379.
[33] K. Kubota, T. Shinozaki, Y. Imai, and K. Kario, “Imatinib dramatically alleviates pulmonary tumour thrombotic microangiopathy induced by gastric cancer,” BMJ Case Reports, p. bcr-2017-221032, Sep. 2017, doi: 10.1136/bcr-2017-221032.
[34] I. Fukada et al., “Imatinib Alleviated Pulmonary Hypertension Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient With Metastatic Breast Cancer,” Clinical Breast Cancer, vol. 15, no. 2, pp. e167–e170, Apr. 2015, doi: 10.1016/j.clbc.2014.10.008.
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Cozzi D, Zantonelli G, Bindi A, Cavigli E, Moroni C, Pieralli F, et al. Vascular tree-in-bud sign in Pulmonary Tumour Thrombotic Microangiopathy (PTTM): CT findings for a difficult radiological early antemortem diagnosis. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2023 Mar. 28 [cited 2024 Jul. 27];40(1):e2023006. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/13378
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How to Cite
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Cozzi D, Zantonelli G, Bindi A, Cavigli E, Moroni C, Pieralli F, et al. Vascular tree-in-bud sign in Pulmonary Tumour Thrombotic Microangiopathy (PTTM): CT findings for a difficult radiological early antemortem diagnosis. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2023 Mar. 28 [cited 2024 Jul. 27];40(1):e2023006. Available from: https://mattioli1885journals.com/index.php/sarcoidosis/article/view/13378
