Antidiabetic effect of kaempferol a flavonoid compound, on streptozotocin-induced diabetic rats with special reference to glycoprotein components

Antidiabetic effect of kaempferol a flavonoid compound, on streptozotocin-induced diabetic rats with special reference to glycoprotein components

Authors

  • Govindasamy Chandramohan Department of Community Health Sciences College of Applied Medical Sciences King Saud University P.O. Box 10219, Riyadh 11433 Saudi Arabia
  • Khalid S. Al-Numair Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh - Saudi Arabia
  • Mohammed A. Alsaif Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh - Saudi Arabia
  • Chinnadurai Veeramani Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh - Saudi Arabia

Keywords:

Plasma glucose, diabetes, glycoproteins, kaempferol, streptozotocin

Abstract

Flavonoids have anti-inflammatory and antioxidative effects and thus may protect against diabetic complications. In our early study, kaempferol at an optimum dose of 100 mg was decreased plasma glucose level and increased the insulin levels and also kaempferol exhibited hypolipidemic action in streptozotocin-diabetic rats after 45 days of treatment. The aim of this study was planned to investigate the effect of kaempferol a flavonoid compound on plasma and tissues glycoprotein components in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into adult male albino rats of the Wistar strain, weighing 180–200 g, by intraperitoneal administration of streptozotocin (40 mg/kg of body weight (BW)). Kaempferol at a dose of 100 mg/kg BW was administered once daily for 45 days to normal and STZ-induced diabetic rats. The levels of plasma and tissues (liver, kidney and heart) glycoproteins containing hexoses, hexosamines and fucose were increased significantly in diabetic rats. In addition, the level of sialic acid significantly increased in plasma, liver and heart while decreased in kidney of STZ-induced diabetic rats. Treatment of kaempferol to diabetic rats, the above metabolic alteration of glycoprotein reverted towards normal level. These results indicate that kaempferol can potentially ameliorate glycoprotein abnormalities related to the risk of diabetes mellitus.

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Published

20-10-2014

Issue

Vol. 17 No. 1 (2015)

Section

Original articles

License

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How to Cite

1.
Chandramohan G, Al-Numair KS, Alsaif MA, Veeramani C. Antidiabetic effect of kaempferol a flavonoid compound, on streptozotocin-induced diabetic rats with special reference to glycoprotein components. Progr Nutr [Internet]. 2014 Oct. 20 [cited 2025 Feb. 22];17(1):50-7. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/3587

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