Dose-escalation study with supplemental creatine-guanidinoacetate in healthy adults

Sergej Ostojic; Gábor  Farkas; Zsófia  Bábszky; Valdemar Stajer

doi:10.23751/pn.v26i3.16416

Authors

Sergej Ostojic Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia; Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway; Faculty of Health Sciences, University of Pécs, Pécs, Hungary
Gábor Farkas Research Institute of Sport Science, Hungarian University of Sports Science, Budapest, Hungary; Hungarian Wrestling Academy “Kozma István”, Budapest, Hungary
Zsófia Bábszky Research Institute of Sport Science, Hungarian University of Sports Science, Budapest, Hungary; Hungarian Wrestling Academy “Kozma István”, Budapest, Hungary
Valdemar Stajer Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia

Keywords:

creatine, guanidinoacetate, homocysteine, dose-escalating

Abstract

Background and aim: A co-administration of creatine and guanidinoacetate (GAA) emerges as a promising dietary intervention yet limited information is currently available regarding its safety for dose-escalating studies. In this open-label pilot study, we assessed the impact of escalating doses of supplemental creatine-GAA on total homocysteine levels (T-Hcy) in the plasma of healthy adults

Methods:Eight young, physically active volunteers (age 22.5 ± 2.2 years, weight 64.1 ± 10.8 kg, height 165.4 ± 7.1; six females) provided informed consent to receive three escalating doses of the mixture, each administered for four weeks.

Results:One-way ANOVA analysis revealed no significant differences in mean T-Hcy levels across the study (P = 0.76). Moreover, no cases of hyperhomocysteinemia (T-Hcy > 15 µmol/L) were observed during the study period.

Conclusions: These findings suggest that the mixture is generally well-tolerated when administered up to three grams each of creatine and GAA over a three-month dose-escalating protocol in healthy adults, with no significant increase in homocysteine levels.

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