Effect of maternal thyroid hormone levels in late pregnancy on risk of singleton low birth weight

Authors

  • Qing Lin a:1:{s:5:"en_US";s:113:"Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics&Gynecology and Pediatrics";}

Keywords:

thyroid hormone, pregnancy, low birth weight

Abstract

Aim: To explore the effect of maternal thyroid hormone levels in late pregnancy on the risk of singleton low birth weight (LBW). Methods: A total of 3757 puerperae who gave birth from September 2019 to October 2020 were divided into case group (n=249, <2500 g) and control group (n=3508, >2500 g). The baseline clinical data of puerperae were collected, and the thyroid hormone levels were compared. The factors with differences were incorporated into LASSO-logistic multivariate regression analysis, the associations between clinical data and thyroid hormone levels were analyzed, and the predictive efficiencies of thyroid hormones for the risk of LBW were assessed using receiver operating characteristic (ROC) curves. Results: Case group had lower level of free triiodothyronine (FT3) and higher levels of free thyroxine (FT4) and thyroid-stimulating hormone (TSH) than those of control group (P<0.05). The results of LASSO-logistic regression analysis showed that FT3, FT4 and TSH levels were independent influencing factors for the risk of singleton LBW. The FT3 level was negatively correlated with premature labor, gestational hypertension, gestational anemia and fewer prenatal examinations, the FT4 level was positively correlated with premature labor and placenta previa, and the TSH level had positive correlations with premature labor, gestational hypertension and gestational anemia. According to ROC analysis, the FT3, FT4 and TSH levels had high predictive efficiencies for the risk of LBW. Conclusion: The decreased level of maternal FT3 and increased levels of FT4 and TSH in late pregnancy raise the risk of singleton LBW.

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Published

21-03-2023

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Original articles

How to Cite

1.
Effect of maternal thyroid hormone levels in late pregnancy on risk of singleton low birth weight. Progr Nutr [Internet]. 2023 Mar. 21 [cited 2024 Mar. 28];25(1):e2023005. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/13401