The impact of combined nutraceutical supplementation on Work-related stress, mood and eating disorders during the menopausal transition: a pilot study. Work-related stress, mood and eating disorders during the menopausal transition

Main Article Content

Diana M Conti
Gianna M Agnelli
Ksenia Jessica Chiroque Cruz
Silvia Caterina Maria Tomaino
Chiara Favero
Elisabetta Marchiori
Giovanna Gambino
Luisella Maria Vigna


menopause, work-related stress, eating disorders, mood disorders, nutraceutic


Objectives: Menopause represents a “window of vulnerability” in women’s life. This transition   comprehends many changes: physical, metabolical and psychological. It could, also, cause difficulties at work and the most problematic symptoms are poor concentration and  memory, tiredness,  feeling depressed and lowered confidence. Moreover food became, often, a practical, easy and fast solution to manage negative emotions.

The aims of this pilot study were:  to analyze the existence of a possible link between menopausal transition, mood, eating behavior and well-being perception on the workplace and to verify the possible influence of  nutraceutical supplementation on  the above mentioned disorders.


 40 women, with mean  age 52 years old and mean  BMI 33.27 were enrolled  and  divided into two groups: diet + behavioral advices  (D), or diet + behavioral advices  and a nutraceutical compound   (D+N) for four months.

The following psychological questionnaires  were administrated at the beginning and after four months:   

Zung  depression scale, (ZUNG);  Binge Eating Scale (BES): Job Content Questionnaire (JCQ)  used to measure the investigate job  related stress.  After the test, each woman had an individual psychological interview aimed to investigate her personal experiences, related to what arose  from the results.


After four months: women (D+N) achieved a statistically significant improvement in both tests (Zung p <0.0001 Bes p <0.0083). The women  (D) had no statistically significant changes in BES, even if there was better management of feeding behavior, and  Zung did not show  an improvement in mood.

JCQ analysis showed:   women (D+N)  had a slight increase of decision-making capacity (DL 64 to 66) compared with an unchanged workload (JD 33 to 33.5); social-support perception (SS ) showed a   slight improvement even if it remained below the median line of the reference sample. In the (D) group we observed a slight increase of the workload , accompanied by  a reduction of the decision-making capacity (DL 74 to 69) and by  a slight lowering of the perception of the social support (SS).


Conclusions: the combination of a diet  program, behavioural advice  and  nutraceuticals, compared  to the sole diet,  made it possible to relieve the emotional and eating disturbs related to the menopause and to improve the perception of a satisfactory work.


Download data is not yet available.
Abstract 87 | PDF Downloads 44


1. Bacon JL. “ The menopausal transition”, Obstet Gynecol Clin North Am. 2017 Junc;44(2):285-596. doi: 10.1016/j.ogc.2017.02.008.

2. Dibonaventura MD, Wagner JS, Alvir J, Whiteley J. “Depression, quality of life, work productivity, resource use, and costs among women experiencing menopause and hot flashes: a cross-sectional study”, Prim Care Companion CNS Disorder 2012; 14(6).

3. Lampio L, Saaresranta T, Polo O, Polo-Kantola P. “Subjective sleep in pre-menopausal and post-menopausal women during workdays and leisure days: a sleep diary study”. Menopause. 2013 Jun; 20(6):655-60.

4. Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN). Linee guida per una sana alimentazione italiana. 2003. [U.d.a. giugno 2012]

5. Ministero Della Salute. Lo stato di salute delle donne in Italia. 2008 htttp:// [u.d.a. giugno 2012]

6. Griffiths A. Menopause and work: An electronic survey of employees’ attitudes in the UK. Maturitas 2013 7: 2,Pages 155-159,

7. Geukes M, Anema JR, van Aalst MP, de Menezes RX, Oosterhof H. “Improvement of menopausal symptoms and the impact on work ability: A retrospective cohort pilot study”, Maturitas. 2019 Feb;120:23-28. doi: 10.1016/j.maturitas.2018.10.015. Epub 2018 Nov 5.
8. Magweth–Matzek B. “The Menopausal Transition A Possible Window of Vulnerability for Eating Pathology” Int J Eat Disord 2013; 46:609–616.
9. Brzezinski A. “Menopausal symptoms: not just estrogen deficiency”, Menopause. 2019 Mar;26(3):229-230. doi: 10.1097/GME. 290.
10. Zhang JP, Wang YQ, Yan MQ, et al “Menopausal Symptoms and Sleep Quality During Menopausal Transition and Postmenopause, .Chin Med J (Engl). 2016 Apr 5;129(7):771-7. doi: 10.4103/0366-6999.178961
11. Evans M, Elliott JG, Sharma P, Berman R, Guthrie N. The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: A multi-center, randomized, placebo-controlled study Maturitas 2011 68 189–196.
12. Rondanelli M, Opizzi A, Faliva M, Bucci M, Perna S. Relationship between the absorption of 5-hydroxytryptophan from an integrated diet, by means of Griffonia simplicifolia extract, and the effect on satiety in overweight females after oral spray administration. Eat Weight Disord. 2012 Mar;17(1):e22-8. Doi: 10.3275/8165.
13. Khan AW, Khan A, Ahmed T Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis. Front. Pharmacol. 2016 7:499. doi: 10.3389/fphar.2016.00499
14. Balsamo M, e Saggino A. “Test per l’assessment della depressione nel contesto italiano: un’analisi critica” Psicoterapia Cognitiva e Comportamentale - Vol. 13 - n. 2, 2007.
15. Di Bernardo M. “Validazione della versione italiana della Binge Eating Scale in pazienti obesi”, Minerva Psich, 39, 125-30, 1998.
16. Baldasseroni A. “ La valutazione del benessere psicofisico. Dati preliminari relativi a un campione di lavoratori addetti a sportello postale informatizzato.” In Violante F, Sarchielli G, Depolo M (eds): Atti del seminario Fattori psicosociali, lavoro e salute. Cesena, 9-10 novembre 1998. Cesena: Il Ponte Vecchio, 1998: 101-106.
17. Karasek R, Theorell T. “Autonomia e salute sul lavoro. Stress produttività e riorganizzazione del lavoro”, Ferrari Sinibaldi Edizioni, 2012.
18. Vann Gennepp A. “I riti di passaggio”, Bollati Boringhieri, 2012.
19. Flacco F.“L’invisibile in menopausa. Psicologia del benessere nella crisi di transizione della mezza età”, Franco Angeli Editore, 2010.
20. Gracia CR, Freeman EW.” Onset of the Menopause Transition: The Earliest Signs and Symptoms”, Obstet Gynecol Clin North Am.2018 Dec;45(4):585-597. doi: 10.1016/j.ogc.2018.07.002. Epub 2018 Oct 25.
21. INAIL. Dati Andamento degli infortuni sul lavoro. Mestiere Donna. 2008. [U.d.a. giugno 2012]
22. Brown L, Bryant C, Judd FK , “Positive well-being during the menopausal transition: a systematic review”,Climacteric. 2015;18(4):456-69. doi: 10.3109/13697137.2014.989827. Epub 2015 Feb 18. Review