Effect of saffron on serum leptin levels in patients with metabolic syndrome, a double-blind, randomized and placebo-controlled trial study

Effect of saffron on serum leptin levels in patients with metabolic syndrome, a double-blind, randomized and placebo-controlled trial study

Authors

  • Marzie Zilaee
  • Mohammad Soukhtanloo Biochemistry Department, school of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Majid Ghayour-Mobarhan Cardiovascular Research Center, school of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Maryam Shemshian Cardiovascular Research Center, school of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Maryam Salehi Department of Community Medicine, school of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Gordon A.A. Ferns Institute for Science & Technology in Medicine, Thornburrow Drive, University of Keele, Stoke on Trent, Staffordshire, ST4 7QB, UK
DOI: https://doi.org/10.23751/pn.v20i1-S.6078

Keywords:

Keywords, Leptin, Saffron, Metabolic Syndrome

Abstract

Background: Metabolic syndrome is a risk factor for cardiovascular disease and diabetes mellitus. A decreased level of serum leptin is reported for obese populations. Beneficial effects of saffron on human health, including appetite-regulation, have been reported previously. The aim of this study was to investigating the effect of saffron supplementation on serum leptin levels in patients with metabolic syndrome. Material and method: Patients with metabolic syndrome were randomly divided into two groups; a case group, receiving saffron and a control group, receiving placebo. Concentration of serum leptin was measured at baseline and after 12 weeks of the start of study. SPSS software was used to analyze the data. Results: There was a borderline (p=0.05) significant difference in serum leptin before and after treatment with saffron, but not in the placebo group. There was a significant difference in serum leptin concentrations between the groups (p=0.001). Conclusion: Saffron supplementation has no significant effect on serum leptin levels in patients with metabolic syndrome.

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Published

06-08-2018

Issue

Vol. 20 No. 1-S (2018): Supplement: Nutraceutical, Medicinal Plants and Functional Foods

Section

Original articles

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

1.
Zilaee M, Soukhtanloo M, Ghayour-Mobarhan M, Shemshian M, Salehi M, Ferns GA. Effect of saffron on serum leptin levels in patients with metabolic syndrome, a double-blind, randomized and placebo-controlled trial study. Progr Nutr [Internet]. 2018 Aug. 6 [cited 2025 Feb. 22];20(1-S):140-4. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/6078
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