The effect of gluten free diet on markers of celiac disease and association with behavioral symptoms in children diagnosed with Autism Spectrum Disorders

Faezeh Ghalichi; Alireza Ostadrahimi; Ayyoub Malek; Jamal Ghaemmaghami

The effect of gluten free diet on markers of celiac disease and association with behavioral symptoms in children diagnosed with Autism Spectrum Disorders

Authors

Faezeh Ghalichi Nutrition Research Center, Department of Science Nutrition, Tabriz University of Medical Sciences (TUOMS), Tabriz, Iran
Alireza Ostadrahimi Nutrition Research Center, Department of Biochemistry and Dietetics, Tabriz University of Medical Sciences (TUOMS), Tabriz, Iran
Ayyoub Malek Clinical Psychiatry Research Center (CPRC), Department of Psychiatry, Tabriz University of Medical Sciences (TUOMS), Tabriz, Iran
Jamal Ghaemmaghami Nutrition Research Center, Department of Biochemistry and Dietetics, Tabriz University of Medical Sciences (TUOMS), Tabriz

Keywords:

Autism Spectrum Disorders, Gluten, Celiac, tissue Transglutaminase, Endomysium antibody

Abstract

Purpose: The objectives of this study were to measure markers of celiac disease before and after implementing a gluten free diet and also evaluating its association with autism severity. Methods: The present randomized clinical trial was accomplished over 80 subjects diagnosed with Autism Spectrum Disorders (ASD) by the Autism Diagnostic Interview-Revised (ADI-R). Participants were randomly divided into Gluten Free Diet (GFD) and regular diet groups for 6 weeks. Immunological markers consisting of IgA, tTGIgA, tTGIgG and EMAIgG were measured. Findings: In this study, 6 patients were tTGIgA positive. In the GFD group, tTGIgA decreased insignificantly (from 3.62 ± 4.25 to 3.41 ± 3.51 U/ml; P<0.05) while it increased significantly (from 2.80 ± 3.54 to 3.96 ± 4.10 U/ml; P<0.05) in the regular diet group. Conclusion: These results suggest an underlying immune reactivity to gluten in a subset of children with ASD; however, celiac disease (CD) was not detected in any of the cases. Further investigations are necessary to clarify the possible relationship between ASD and celiac disease. Iranian Registry of Clinical Trials (IRCT201404212017N20), http://www.irct.ir

Downloads

Published

17-06-2016

Issue

Vol. 18 No. 2 (2016)

Section

Original articles

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Ghalichi F, Ostadrahimi A, Malek A, Ghaemmaghami J. The effect of gluten free diet on markers of celiac disease and association with behavioral symptoms in children diagnosed with Autism Spectrum Disorders. Progr Nutr [Internet]. 2016 Jun. 17 [cited 2025 Feb. 22];18(2):118-24. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/4477

Download Citation

Most read articles by the same author(s)

Abdolrasoul Safaeiyan, Alireza Ostadrahimi, Mahzad Sanayei, Yousef Rasmi, Parizad Taraghijou, Effect of omega-3 fatty acids on appetite, energy and macronutrient intake and body weight in obese adults: a randomized clinical trial , Progress in Nutrition: Vol. 20 No. 2-S (2018): Supplement 2/2018
Abed Ghavami, Neda Roshanravan, Elyas Nattagh-Eshtivani, Shima Sharifi, Peshawa Arzhang, Mahmood Alizadeh Sani, Mohsen Hemmati Dinarvand, Ali Shokri, Alireza Ostadrahimi, The effect of high performance inulin on appetite, energy intake and anthropometric indices in patient with type 2 diabetes , Progress in Nutrition: Vol. 21 No. 2-S (2019): Supplement 2/2019: Community nutrition from childhood to old age
Seyed Mohammad Hosein Mousavi Jazayeri, Alireza Ostadrahimi, Abdolrasoul Safaiyan, Shahryar Hashemzadeh, Firouz Salehpour, Standard enteral feeding improves nutritional status compared with hospital-prepared blended formula among Intensive Care Unit (ICU) patients , Progress in Nutrition: Vol. 18 No. 1 (2016)
Farzad Razmifard, Abolfazl Barzeghari, Nazila Farrin, Abdolrasoul Safaiyan, Seyyed Jamal Ghaem-maghami, Majid Mobasseri, Seyedeh-Maryam Sodabi, Sevda Saleh-Ghadimi, Alireza Ostadrahimi, Changes in Akkermansia muciniphila and its relationship with dietary habits in type 2 diabetic obese patients , Progress in Nutrition: Vol. 21 No. 1-S (2019): Supplement 1/2019: Community nutrition from childhood to old age
Eynollah Valizadeh, Hossein Akbari, Faezeh Ghalichi, Alireza Ostadrahimi, The “Mohazell” herbal formula in combination with a calorie-restricted diet can improve systemic inﬂammation in obesity: a randomized double-blind, clinical trial , Progress in Nutrition: Vol. 21 No. 1-S (2019): Supplement 1/2019: Community nutrition from childhood to old age
Nasim Abedimanesh, Behrooz Motlagh, Saeed Abedimanesh, Alireza Ostadrahimi, Mohammad Hossein Somi, Mohammad Asghari Jafarabadi, Mahin Rezazadeh, Circulating resistin in ulcerative colitis, relation with anthropometric, body composition and inflammatory parameters , Progress in Nutrition: Vol. 20 No. 2-S (2018): Supplement 2/2018
Rasoul Mokhtari, Faezeh Ghalichi, Asghari Jafarabadi Mohammad, Ali Barzegar, Assessing and comparing nutritional status and related factors among 6-48 months old children born in the damaged rural and urban areas of Varzeghan after the 2012 earthquake , Progress in Nutrition: Vol. 21 No. 2-S (2019): Supplement 2/2019: Community nutrition from childhood to old age
Seyed Mohammad Hosein Mousavi Jazayeri, Abdolrasoul Safaiyan, Alireza Ostadrahimi, Shahryar Hashemzadeh, Firouz Salehpour, Correlation between inflammatory markers and organ dysfunction among Intensive Unit Care patients , Progress in Nutrition: Vol. 20 No. 1-S (2018): Supplement: Nutraceutical, Medicinal Plants and Functional Foods
Seyed Mohammad Hosein Mousavi Jazayeri, Alireza Ostadrahimi, Shahryar Hashemzadeh, Abdolrasoul Safaiyan, Firouz Salehpour, Meisam Barati, Fatemeh Azizi-Soleima, Proportions of prognostic scoring models among ICU patients receiving enteral nutrition , Progress in Nutrition: Vol. 20 No. 4 (2018)
Seyed Mohammad Hosein Mousavi Jazayeri, Alireza Ostadrahimi, Abdolrasoul Safaiyan, Shahryar Hashemzadeh, Firouz Salehpour, Effects of four different enteral feeding methods on tumor Necrosis Factor-α (TNF-α) and high sensitive C-Reactive Protein (hs-CRP) in critically Ill Patients: double blinded, randomized controlled trial , Progress in Nutrition: Vol. 18 No. 3 (2016)