Comparative study of molecular mechanism of action of allopathic drugs and herbal drugs: A mini review

Main Article Content

Pramod Kumar Singh
Ajay Kumar Gautam
Nidhi Puranik
Dr.Bijendra Rai
Dhananjay Yadav

Keywords

Type 2 Diabetes; Herbal drugs; Phytochemicals, Molecular mechanism

Abstract

Different kinds of allopathic medications are already accessible that operate admirably in managing sugar levels through their distinct action mechanisms; nonetheless, the point of worry is that they cause our body organs to overwork or, in other words, they overstress our bodies. Quite a few allopathic medicines are known to cause adverse reactions. None of these however provide a cure for diabetes, although they do assist in successful diabetic control. Polyherbal formulations are a concept unique to Ayurveda. Natural compounds commonly known as phytochemicals originating from plants have played a significant part in medication development efforts and still do. Given the toxicity and myriad negative consequences of allopathic medications, it is possible to greatly expand the number of herbal drug manufacturing enterprises, which is related to the current growth in interest and demand for herbal medicines. Additionally, plant-based phytochemical medications offer a plentiful supply of physiologically active substances with pharmacological action and little side effects. Since various preparations function by distinct mechanisms, theoretically alternative combinations of these extracts may be more successful in lowering blood glucose levels. In this study, we sought to elucidate the mechanism of plant phytochemical anti-diabetic properties in polyherbal formulations.

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References

1. Standards of medical care in diabetes--2012. Diabetes Care 2012; 35 Suppl 1: S11-63.
2. Balaji R, Duraisamy R, Kumar M. Complications of diabetes mellitus: A review. Drug Invention Today 2019; 12.
3. Davidson MB, Peters AL. An overview of metformin in the treatment of type 2 diabetes mellitus. The American journal of medicine 1997; 102: 99-110.
4. Genuth S. Exogenous insulin administration and cardiovascular risk in non-insulin-dependent and insulin-dependent diabetes mellitus. Annals of internal medicine 1996; 124: 104-9.
5. Blahova J, Martiniakova M, Babikova M, Kovacova V, Mondockova V, Omelka R. Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus. Pharmaceuticals 2021; 14: 806.
6. Madhukar DS, Laxman GK, Shivaji GP, Vasant HM, Kailas IS, Dnyaneshwar JM. A REVIEW ON ANTIDIABETIC DRUGS (ALLOPATHY). 2022.
7. Proks P, Reimann F, Green N, Gribble F, Ashcroft F. Sulfonylurea Stimulation of Insulin Secretion. Diabetes 2002; 51: S368-S76.
8. Tiikkainen M, Häkkinen A-M, Korsheninnikova E, Nyman T, Mäkimattila S, Yki-Järvinen H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 2004; 53: 2169-76.
9. Lebovitz HE. Alpha-glucosidase inhibitors. Endocrinology and metabolism clinics of North America 1997; 26: 539-51.
10. Sels J-PJ, Huijberts MS, Wolffenbuttel BH. Miglitol, a new α-glucosidase inhibitor. Expert opinion on pharmacotherapy 1999; 1: 149-56.
11. Kahn CR, Chen L, Cohen SE. Unraveling the mechanism of action of thiazolidinediones. The Journal of clinical investigation 2000; 106: 1305-7.
12. Schoonjans K, Auwerx J. Thiazolidinediones: an update. The Lancet 2000; 355: 1008-10.
13. Rother KI. Diabetes treatment—bridging the divide. The New England journal of medicine 2007; 356: 1499.
14. Yadav D, Tiwari A, Mishra M et al. Anti-hyperglycemic and anti-hyperlipidemic potential of a polyherbal preparation “diabegon” in metabolic syndrome subject with type 2 diabetes. African Journal of Traditional, Complementary and Alternative Medicines 2014; 11: 249-56.
15. Atale N, Yadav D, Rani V, Jin J-O. Pathophysiology, clinical characteristics of diabetic cardiomyopathy: therapeutic potential of natural polyphenols. Frontiers in Nutrition 2020; 7: 564352.
16. Yogisha S, Raveesha KA. Dipeptidyl Peptidase IV inhibitory activity of Mangifera indica. J Nat Prod 2010; 3: 9.
17. Mahajan S, Chauhan P, Mishra M, Yadav D, Debnath M, Prasad G. Antidiabetic potential of Eugenia jambolana ethanolic seed extract: effect on antihyperlipidemic and antioxidant in experimental streptozotocin-induced diabetic rats. Advances in Complementary & Alternative Medicine 2018; 2: 1-9.
18. Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes care 1989; 12: 553-64.
19. Alam S, Sarker MMR, Sultana TN et al. Antidiabetic Phytochemicals from Medicinal Plants: Prospective Candidates for New Drug Discovery and Development. Frontiers in Endocrinology 2022; 13.
20. Gogtay N, Bhatt H, Dalvi S, Kshirsagar N. The use and safety of non-allopathic Indian medicines. Drug safety 2002; 25: 1005-19.
21. Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: Concept of ayurveda. Pharmacognosy reviews 2014; 8: 73.
22. Samal J. Fundamental tenets of epidemiology in Ayurveda and their contemporary relevance. Indian Journal of Health Sciences and Biomedical Research (KLEU) 2016; 9: 20.
23. Gupta RC, Chang D, Nammi S, Bensoussan A, Bilinski K, Roufogalis BD. Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications. Diabetology & Metabolic Syndrome 2017; 9: 59.
24. Rao MU, Sreenivasulu M, Chengaiah B, Reddy KJ, Chetty CM. Herbal medicines for diabetes mellitus: a review. Int J PharmTech Res 2010; 2: 1883-92.
25. Soetan K. Pharmacological and other beneficial effects of antinutritional factors in plants-A review. African journal of Biotechnology 2008; 7.
26. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990; 30: 295-300.
27. Gupta S, Variyar M. Experimental studies on pituitary diabetes. Iv. Effect of Gymnema sylvestre and Coccinia indica against the hyperglycaemic response of somatotropin and corticotropin hormones. The Indian journal of medical research 1964; 52: 200-7.
28. Gupta S. Inhibitory effect of Gymnema sylvestre (Gurmar) on adrenaline-induced hyperglycemia in rats. Indian journal of medical sciences 1961; 15: 883-7.
29. Anandharajan R, Pathmanathan K, Shankernarayanan NP, Vishwakarma RA, Balakrishnan A. Upregulation of Glut-4 and PPAR gamma by an isoflavone from Pterocarpus marsupium on L6 myotubes: a possible mechanism of action. J Ethnopharmacol 2005; 97: 253-60.
30. Sen S, Roy M, Chakraborti AS. Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats. J Pharm Pharmacol 2011; 63: 287-96.
31. Ahmad Khan F, Khalid P, Khan M, Rastogi A, Kidwai J. Insulin like activity in (−) epicatechin. Acta Diabetologica 1989; 26: 291-300.
32. Chagas VT, Coelho RMRdS, Gaspar RS et al. Protective effects of a polyphenol-rich extract from Syzygium cumini (L.) skeels leaf on oxidative stress-induced diabetic rats. Oxidative medicine and cellular longevity 2018; 2018.
33. Bopana N, Saxena S. Asparagus racemosus--ethnopharmacological evaluation and conservation needs. J Ethnopharmacol 2007; 110: 1-15.
34. Pari L, Satheesh MA. Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes. Journal of ethnopharmacology 2004; 91: 109-13.
35. Galani VJ, Patel B, Rana D. Sphaeranthus indicus Linn.: A phytopharmacological review. International Journal of Ayurveda Research 2010; 1: 247.
36. Sangeetha M, Priya CM, Vasanthi HR. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes. Phytomedicine 2013; 20: 246-8.
37. Zhang Y, Li X, Zou D et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of Clinical Endocrinology & Metabolism 2008; 93: 2559-65.
38. Phoboo S, Pinto MDS, Bhowmik PC, Jha PK, Shetty K. Quantification of major phytochemicals of Swertia chirayita, a medicinal plant from Nepal. Ecoprint: An International Journal of Ecology 2010; 17: 59-68.
39. Shah K, Patel M, Patel R, Parmar P. Mangifera indica (mango). Pharmacognosy reviews 2010; 4: 42.
40. Ghanbari A, Moradi M, Raoofi A, Falahi M, Seydi S. Efectos de la Administración del Extracto Hidroalcohólico Tribulus terrestris sobre los Parámetros Reproductivos y el Nivel Sérico de Glucosa en Ratas Macho Diabéticas. International Journal of Morphology 2016; 34: 796-803.
41. Li M, Qu W, Wang Y, Wan H, Tian C. [Hypoglycemic effect of saponin from Tribulus terrestris]. Zhong Yao Cai 2002; 25: 420-2.
42. Obianime A, Uche F. The Phytochemical screening and the effects of methanolic extract of Phyllanthus amarus leaf on the Biochemical parameters of Male guinea pigs. Journal of Applied Sciences and Environmental Management 2008; 12.
43. Rao DV. Occurrence of luteolin in the leaves of Gmelina arborea Linn. Curr Sci 1967; 36: 71-2.
44. Dwivedi C, Daspaul S. Antidiabetic herbal drugs and polyherbal formulation used for diabetes: A review. J Phytopharmacol 2013; 2: 44-51.
45. Hsia SH, Bazargan M, Davidson MB. Effect of Pancreas Tonic (an ayurvedic herbal supplement) in type 2 diabetes mellitus. Metabolism 2004; 53: 1166-73.
46. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA. Indian herbs and herbal drugs used for the treatment of diabetes. Journal of clinical biochemistry and nutrition 2007; 40: 163-73.
47. Baqri SSR, Suryavanshi A, Saxena A, Bajpai KG. Trends in Herbal Drug Development for Glycemic Control: New Insights on Medicinal Flora in India.
48. Kaur M, Valecha V. Diabetes and antidiabetic herbal formulations: an alternative to Allopathy. Eur J Med 2014; 6: 226-40.
49. Katiyar D, Singh V, Gilani SJ, Goel R, Grover P, Vats A. Hypoglycemic herbs and their polyherbal formulations: a comprehensive review. Medicinal Chemistry Research 2015; 24: 1-21.
50. Fu Z, R Gilbert E, Liu D. Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Current diabetes reviews 2013; 9: 25-53.

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