Effect of a combined mulberry-sage dietary supplement on food craving and body weight: a pilot clinical trial Mulberry and Sage extract for food craving

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Arrigo F.G. Cicero
Federica Fogacci
Maddalena Veronesi
Antonio Di Micoli
Marilisa Bove


Food craving, Weight loss, Dietary supplement, Mulberry, Sage, Clinical trial


Background and aim: Overweight and obesity are largely prevalent in developed and developing countries, being risk factors for type 2 diabetes, cardiovascular disease and all-causes mortality. The aim of this pilot study was to test the effect of a combined mulberry-sage dietary supplement on food craving and body weight in healthy overweight subjects.

Methods: This is a randomized, single-blind, clinical trial, involving 40 overweight healthy subjects randomized to assume a combined dietary supplement containing mulberry and sage extracts vs. standard diet. The volunteers were visited after 14, 28 and 56 days, sampling anthropometric data and the scores of the Food Cravings Questionnaire–Trait (FCQ–T) and the Short Form Health Survey 36 (SF-36).

Results: The active treatment waswell-tolerated and all patients completed the study. After 56 days of intake, the subjects treated with the tested dietary supplement on top of a standard diet experienced a significant improvement in FCQ-T, SF-36 and percentage fat mass versus standard diet only treated ones (p<0.05). FCQ-T improved just after 14 days versus placebo in the dietary supplement treated subjects, only.

Conclusions: In conclusion, the tested dietary supplement seemed to mildly but significantly support body weight loss by decreasing food craving in healthy overweight subjects.


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1. World Health Organization. Health topics: obesity. Geneva, Switzerland: World Health Organization; 2011. Available at: http://www.who.int/topics/obesity/en/ [Google Scholar]
2. Rebello CJ, Greenway FL. Reward-Induced Eating: Therapeutic Approaches to Addressing Food Cravings. AdvTher. 2016;33(11):1853-1866.
3. Li Y, Schoufour J, Wang DD, et al. Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study. BMJ. 2020 Jan 8;368:l6669.
4. Sun W, Kober H. Regulating food craving: From mechanisms to interventions. Physiol Behav. 2020;222:112878.
5. Mahboubi M. Morusalba (mulberry), a natural potent compound in management of obesity. Pharmacol Res. 2019 ;146:104341.
6. Al Shukor N, Ravallec R, Van Camp J, et al. Flavonoids stimulate cholecystokinin peptide secretion from the enteroendocrine STC-1 cells. Fitoterapia. 2016 Sep;113:128-31.
7. Boccellino M, D'Angelo S. Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities. Int J Mol Sci. 2020 Aug 6;21(16):5642.
8. Cepeda-Benito A, Gleaves DH, Fernández MC, et al. The development and validation of Spanish versions of the State and Trait Food Cravings Questionnaires. Behav Res Ther. 2000 Nov;38(11):1125-38.
9. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473-83.
10. DurrerSchutz D, Busetto L, Dicker D, et al. European Practical and Patient-Centred Guidelines for Adult Obesity Management in Primary Care. Obes Facts. 2019;12(1):40-66.
11. Lin YC, Wu CJ, Kuo PC, et al. Quercetin 3-O-malonylglucoside in the leaves of mulberry (Morusalba) is a functional analog of ghrelin. J Food Biochem. 2020 Sep;44(9):e13379.
12. Ngo YL, Lau CH, Chua LS. Review on rosmarinic acid extraction, fractionation and its anti-diabetic potential. Food Chem Toxicol. 2018;121:687-700.