The effects of dietary intervention with turmeric on lipid profile and anthropometric indices in overweight/obese women with hyperlipidemia: a randomized controlled clinical trial
Main Article Content
Keywords
curcumin, turmeric, lipid profile, anthropometric indices, obesity
Abstract
Background and Objective: The objective of this trial was to evaluate the effects of turmeric on blood lipids and body weight loss in overweight/obese women with hyperlipidemia.
Methods and Study Desing: In this randomized controlled trial, overweight/obese hyperlipidemic women (BMI>25 kg/m2) were randomly divided into 2 groups as turmeric (n=35; 4 g/d) and control (n=35) groups for 8 weeks. The subjects included in the turmeric and control groups adhered to a medical nutrition therapy. Serum lipid profile and anthropometric data were measured at the beginning and again at the end of the study.
Results: After 8 weeks of dietary intervention, both turmeric and control groups showed significant decreased in total cholesterol (‑55.66 versus ‑53.06 mg/dl), LDL‑C (‑35.70 versus ‑35.91 mg/dl) and TG (‑44.34 versus ‑42.03 mg/dl), respectively (p<0.01). Body weight (‑5.05 versus ‑4.91 kg), BMI (‑1.88 versus ‑1.84 kg/m2), body fat ratio (‑4.02 versus ‑3.30%) and waist circumference (‑4.70 versus ‑3.74 cm) were also significantly decreased after dietary intervention in both groups, respectively (p<0.001). No significant difference was found in the reductions of total cholesterol, LDL‑C, TG concentrations or in the reductions of body weight, BMI and waist circumference between the turmeric and control groups (p>0.05).
Conclusions: Further randomized controlled trials with longer supplementation durations are needed for a stronger assessment of the lipid-modulating properties of turmeric.
References
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Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother 2018;99:411-421.
Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multitargeting by turmeric, the golden spice: from kitchen to clinic. Mol Nutr Food Res 2013;57(9):1510-1528.
Sharifi-Rad J, Rayess YE, Rizk AA, et al. Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Front Pharmacol 2020;11:01021.
Boyanapalli SS, Kong A-NT. “Curcumin, the king of spices”: epigenetic regulatory mechanisms in the prevention of cancer, neurological, and inflammatory diseases. Pharmacol Rep 2015;1(2):129-139.
Wongcharoen W, Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol 2009;133(2):145-151.
Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Insect Biochem Physiol 2008;114(2):127-149.
Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol 2015;83:111-124.
Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients 2019;11(8):1837.
Kunnumakkara AB, Sailo BL, Banik K, et al. Chronic diseases, inflammation, and spices: how are they linked? J Transl Med 2018;16(1):1-25.
Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives–A review. J Tradit Complement Med 2017;7(2):205-233.
Hassan F-u, Rehman MS-u, Khan MS, et al. Curcumin as an alternative epigenetic modulator: Mechanism of action and potential effects. Front Genet. 2019;10:514
Sahebkar A. Dual effect of curcumin in preventing atherosclerosis: the potential role of pro-oxidant–antioxidant mechanisms. Nat Prod Res 2015;29(6):491-492.
Campbell MS, Fleenor BS. The emerging role of curcumin for improving vascular dysfunction: A review. Crit Rev Food Sci Nutr 2018; 58(16):2790-2799.
Cicero AF, Colletti A, Bajraktari G, et al. Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Nutr Rev 2017, 75(9):731-767.
Ho JN, Jang JY, Yoon HG, et al. Anti‐obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes. J Sci Food Agric 2012;92(9):1833-1840.
Arafa HM. Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit 2005;11(7):BR228-BR234.
Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care 2012;35(11):2121-2127.
Sahebkar A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clin Nutr 2014;33(3):406-414.
Adab Z, Eghtesadi S, Vafa MR, et al. Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients. Phytother Res 2019;33(4):1173-1181.
Asan SA, Bas M, Eren B, Karaca E. The effects of curcumin supplementation added to diet on anthropometric and biochemical status in women with polycystic ovary syndrome: A randomized, placebo-controlled trial. Prog Nutr 2020;22(4).
Nieman DC, Cialdella-Kam L, Knab AM, Shanely RA. Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach. Plant Foods Hum Nutr 2012;67(4):415-421.
Finkler E, Heymsfield SB, St-Onge M-P. Rate of weight loss can be predicted by patient characteristics and intervention strategies. J Acad Nutr Diet 2012;112(1):75-80.
Miquel J, Bernd A, Sempere J, Dıaz-Alperi J, Ramırez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr 2002;34(1):37-46.
Pekcan, G. Beslenme Durumunun Saptanması, Diyet El Kitabı, (Yazarlar. Baysal A, Aksoy M, Besler T, Bozkurt N, Keçecioğlu S, Mercanlıgil SM, et al.) Ankara: Hatiboğlu Yayınevi (9. Baskı); 2014. pp.108-119.
Sukandar E, Permana H, Adnyana I, et al. Clinical study of turmeric (Curcuma longa L.) and garlic (Allium sativum L.) extracts as antihyperglycemic and antihyperlipidemic agent in type-2 diabetes-dyslipidemia patients. Int J Pharmacol 2010;6(4):456-463.
Amin F, Islam N, Anila N, Gilani A. Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome–A double blind randomized controlled trial–TAK-MetS trial. Complement Ther Med 2015;23(2):165-174.
Selvi NMK, Sridhar M, Swaminathan R, Sripradha R. Efficacy of turmeric as adjuvant therapy in type 2 diabetic patients. Indian J Clin Biochem 2015;30(2):180-186.
Gómez-Téllez A, Sierra-Puente D, Muñoz-Gómez R, et al. Effects of a low-dose spirulina/turmeric supplement on cardiometabolic and antioxidant serum markers of patients with abdominal obesity. Front Nutr 2020;7:65.
Ruiz-Ramie JJ, Barber JL, Sarzynski MA. Effects of exercise on HDL functionality. Curr Opin Lipidol 2019;30(1):16.
Singletary K. Turmeric: potential health benefits. Nutrition Today 2020; 55(1):45-56.
Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J 2017;16(1):1-10.
Iwueke A, Madu W, Chukwu E. Turmeric Powder Gavage Improves Lipid Profile of Albino Rats. J Altern Complement Med 2020:42-46.
Algridi MA, Azab AE. Amelioration of gentamicin induced dyslipidemia in Guinea Pigs by Curcumin and Rosemary. Guigoz Sci Rev 2017;3(2):6-16.
Chanda S, Ramachandra T. Phytochemical and pharmacological importance of turmeric (Curcuma longa): a review. Research and Reviews: A Journal of Pharmacology 2019;9(1):16-23p.
Mughal MH. Turmeric polyphenols: A comprehensive review. Integr Food Nutr Metab 2019;6.
Dolati S, Namiranian K, Amerian R, Mansouri S, Arshadi S, Azarbayjani MA. The effect of curcumin supplementation and aerobic training on anthropometric indices, serum lipid profiles, c-reactive protein and insulin resistance in overweight women: a randomized, double-blind, placebo-controlled trial. J Obes Metab Syndr 2020;29(1):47.
Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Curcumin content of turmeric and curry powders. Nutr Cancer 2006;55(2):126-131.
Wang MY. Spice up your lipids: the effects of curcumin on lipids in humans. Nutrition Bytes.2012;16(1).
Baum L, Cheung SK, Mok VC, et al. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res 2007;56(6):509-514.
Pungcharoenkul K, Thongnopnua P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. Phytother Res 2011;25(11):1721-1726.
Alwi I, Santoso T, Suyono S, et al. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones 2008;40(4):201-210.
Saeedi F, Farkhondeh T, Roshanravan B, Amirabadizadeh A, Ashrafizadeh M, Samarghandian S. Curcumin and blood lipid levels: an updated systematic review and meta-analysis of randomised clinical trials. Arch Physiol Biochem 2020:1-10.
Yuan F, Dong H, Gong J, et al. A systematic review and meta-analysis of randomized controlled trials on the effects of turmeric and curcuminoids on blood lipids in adults with metabolic diseases. Adv Nutr 2019;10(5):791-802.
Saadati S, Hatami B, Yari Z, et al. The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. Eur J Clin Nutr. 2019;73(3):441-449.
Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, et al. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutr Metab (Lond) 2019;16:8.
Cicero AF, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr 2020;59(2):477-483.
Sohaei S, Amani R, Tarrahi MJ, Ghasemi-Tehrani H. The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial. Complement Ther Med 2019;47:102201.
Saraf‐Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M. Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial. Phytother Res 2019;33(8):2015-2022.
Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G. The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetol Metab Syndr 2019;11(1):1-8.
Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC. Lipid‐lowering effects of curcumin in patients with metabolic syndrome: a randomized, double‐blind, placebo‐controlled trial. Phytother Res 2014;28(12):1770-1777.
Mousavi SM, Milajerdi A, Varkaneh HK, Gorjipour MM, Esmaillzadeh A. The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 2020;60(1):171-180.
Akbari M, Lankarani KB, Tabrizi R, et al. The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 2019;10:649.
Boaz M, Kaufman-Shriqui V, Sherf-Dagan S, Salem H, Navarro DA. Frequently used medicinal herbs and spices in weight management: A review. Funct Food Health Dis 2020;10(7):305-324.
Jafarirad S, Mansoori A, Adineh A, Panahi Y, Hadi A, Goodarzi R. Does turmeric/curcumin supplementation change anthropometric indices in patients with non-alcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials. Clin Nutr Res 2019;8(3):196.
le Roux CW, Hartvig NV, Haase CL, Nordsborg RB, Olsen AH, Satylganova A. Obesity, cardiovascular risk and healthcare resource utilization in the UK. Eur J Prev Cardiol 2020:2047487320925639.
Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Eur Rev Med Pharmacol Sci 2015;19(21):4195-4202.
Mohammadi A, Sahebkar A, Iranshahi M, et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res 2013;27(3):374-379.
Rolfe V, Mackonochie M, Mills S, McLennan E. Turmeric/curcumin and health outcomes: a meta-review of systematic reviews. Eur J Integr Med 2020:101252.
Panahi Y, Khalili N, Hosseini MS, Abbasinazari M, Sahebkar A. Lipid-modifying effects of adjunctive therapy with curcuminoids–piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complement Ther Med 2014;22(5):851-857.
Jamwal R. Bioavailable curcumin formulations. A review of pharmacokinetic studies in healthy volunteers. J Integr Med 2018;16(6):367-374.
Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother 2018;99:411-421.
Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multitargeting by turmeric, the golden spice: from kitchen to clinic. Mol Nutr Food Res 2013;57(9):1510-1528.
Sharifi-Rad J, Rayess YE, Rizk AA, et al. Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Front Pharmacol 2020;11:01021.
Boyanapalli SS, Kong A-NT. “Curcumin, the king of spices”: epigenetic regulatory mechanisms in the prevention of cancer, neurological, and inflammatory diseases. Pharmacol Rep 2015;1(2):129-139.
Wongcharoen W, Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol 2009;133(2):145-151.
Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Insect Biochem Physiol 2008;114(2):127-149.
Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol 2015;83:111-124.
Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients 2019;11(8):1837.
Kunnumakkara AB, Sailo BL, Banik K, et al. Chronic diseases, inflammation, and spices: how are they linked? J Transl Med 2018;16(1):1-25.
Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives–A review. J Tradit Complement Med 2017;7(2):205-233.
Hassan F-u, Rehman MS-u, Khan MS, et al. Curcumin as an alternative epigenetic modulator: Mechanism of action and potential effects. Front Genet. 2019;10:514
Sahebkar A. Dual effect of curcumin in preventing atherosclerosis: the potential role of pro-oxidant–antioxidant mechanisms. Nat Prod Res 2015;29(6):491-492.
Campbell MS, Fleenor BS. The emerging role of curcumin for improving vascular dysfunction: A review. Crit Rev Food Sci Nutr 2018; 58(16):2790-2799.
Cicero AF, Colletti A, Bajraktari G, et al. Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Nutr Rev 2017, 75(9):731-767.
Ho JN, Jang JY, Yoon HG, et al. Anti‐obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes. J Sci Food Agric 2012;92(9):1833-1840.
Arafa HM. Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit 2005;11(7):BR228-BR234.
Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care 2012;35(11):2121-2127.
Sahebkar A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clin Nutr 2014;33(3):406-414.
Adab Z, Eghtesadi S, Vafa MR, et al. Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients. Phytother Res 2019;33(4):1173-1181.
Asan SA, Bas M, Eren B, Karaca E. The effects of curcumin supplementation added to diet on anthropometric and biochemical status in women with polycystic ovary syndrome: A randomized, placebo-controlled trial. Prog Nutr 2020;22(4).
Nieman DC, Cialdella-Kam L, Knab AM, Shanely RA. Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach. Plant Foods Hum Nutr 2012;67(4):415-421.
Finkler E, Heymsfield SB, St-Onge M-P. Rate of weight loss can be predicted by patient characteristics and intervention strategies. J Acad Nutr Diet 2012;112(1):75-80.
Miquel J, Bernd A, Sempere J, Dıaz-Alperi J, Ramırez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr 2002;34(1):37-46.
Pekcan, G. Beslenme Durumunun Saptanması, Diyet El Kitabı, (Yazarlar. Baysal A, Aksoy M, Besler T, Bozkurt N, Keçecioğlu S, Mercanlıgil SM, et al.) Ankara: Hatiboğlu Yayınevi (9. Baskı); 2014. pp.108-119.
Sukandar E, Permana H, Adnyana I, et al. Clinical study of turmeric (Curcuma longa L.) and garlic (Allium sativum L.) extracts as antihyperglycemic and antihyperlipidemic agent in type-2 diabetes-dyslipidemia patients. Int J Pharmacol 2010;6(4):456-463.
Amin F, Islam N, Anila N, Gilani A. Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome–A double blind randomized controlled trial–TAK-MetS trial. Complement Ther Med 2015;23(2):165-174.
Selvi NMK, Sridhar M, Swaminathan R, Sripradha R. Efficacy of turmeric as adjuvant therapy in type 2 diabetic patients. Indian J Clin Biochem 2015;30(2):180-186.
Gómez-Téllez A, Sierra-Puente D, Muñoz-Gómez R, et al. Effects of a low-dose spirulina/turmeric supplement on cardiometabolic and antioxidant serum markers of patients with abdominal obesity. Front Nutr 2020;7:65.
Ruiz-Ramie JJ, Barber JL, Sarzynski MA. Effects of exercise on HDL functionality. Curr Opin Lipidol 2019;30(1):16.
Singletary K. Turmeric: potential health benefits. Nutrition Today 2020; 55(1):45-56.
Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J 2017;16(1):1-10.
Iwueke A, Madu W, Chukwu E. Turmeric Powder Gavage Improves Lipid Profile of Albino Rats. J Altern Complement Med 2020:42-46.
Algridi MA, Azab AE. Amelioration of gentamicin induced dyslipidemia in Guinea Pigs by Curcumin and Rosemary. Guigoz Sci Rev 2017;3(2):6-16.
Chanda S, Ramachandra T. Phytochemical and pharmacological importance of turmeric (Curcuma longa): a review. Research and Reviews: A Journal of Pharmacology 2019;9(1):16-23p.
Mughal MH. Turmeric polyphenols: A comprehensive review. Integr Food Nutr Metab 2019;6.
Dolati S, Namiranian K, Amerian R, Mansouri S, Arshadi S, Azarbayjani MA. The effect of curcumin supplementation and aerobic training on anthropometric indices, serum lipid profiles, c-reactive protein and insulin resistance in overweight women: a randomized, double-blind, placebo-controlled trial. J Obes Metab Syndr 2020;29(1):47.
Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Curcumin content of turmeric and curry powders. Nutr Cancer 2006;55(2):126-131.
Wang MY. Spice up your lipids: the effects of curcumin on lipids in humans. Nutrition Bytes.2012;16(1).
Baum L, Cheung SK, Mok VC, et al. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res 2007;56(6):509-514.
Pungcharoenkul K, Thongnopnua P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. Phytother Res 2011;25(11):1721-1726.
Alwi I, Santoso T, Suyono S, et al. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones 2008;40(4):201-210.
Saeedi F, Farkhondeh T, Roshanravan B, Amirabadizadeh A, Ashrafizadeh M, Samarghandian S. Curcumin and blood lipid levels: an updated systematic review and meta-analysis of randomised clinical trials. Arch Physiol Biochem 2020:1-10.
Yuan F, Dong H, Gong J, et al. A systematic review and meta-analysis of randomized controlled trials on the effects of turmeric and curcuminoids on blood lipids in adults with metabolic diseases. Adv Nutr 2019;10(5):791-802.
Saadati S, Hatami B, Yari Z, et al. The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. Eur J Clin Nutr. 2019;73(3):441-449.
Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, et al. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutr Metab (Lond) 2019;16:8.
Cicero AF, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr 2020;59(2):477-483.
Sohaei S, Amani R, Tarrahi MJ, Ghasemi-Tehrani H. The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial. Complement Ther Med 2019;47:102201.
Saraf‐Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M. Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial. Phytother Res 2019;33(8):2015-2022.
Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G. The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetol Metab Syndr 2019;11(1):1-8.
Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC. Lipid‐lowering effects of curcumin in patients with metabolic syndrome: a randomized, double‐blind, placebo‐controlled trial. Phytother Res 2014;28(12):1770-1777.
Mousavi SM, Milajerdi A, Varkaneh HK, Gorjipour MM, Esmaillzadeh A. The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 2020;60(1):171-180.
Akbari M, Lankarani KB, Tabrizi R, et al. The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 2019;10:649.
Boaz M, Kaufman-Shriqui V, Sherf-Dagan S, Salem H, Navarro DA. Frequently used medicinal herbs and spices in weight management: A review. Funct Food Health Dis 2020;10(7):305-324.
Jafarirad S, Mansoori A, Adineh A, Panahi Y, Hadi A, Goodarzi R. Does turmeric/curcumin supplementation change anthropometric indices in patients with non-alcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials. Clin Nutr Res 2019;8(3):196.
le Roux CW, Hartvig NV, Haase CL, Nordsborg RB, Olsen AH, Satylganova A. Obesity, cardiovascular risk and healthcare resource utilization in the UK. Eur J Prev Cardiol 2020:2047487320925639.
Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Eur Rev Med Pharmacol Sci 2015;19(21):4195-4202.
Mohammadi A, Sahebkar A, Iranshahi M, et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res 2013;27(3):374-379.
Rolfe V, Mackonochie M, Mills S, McLennan E. Turmeric/curcumin and health outcomes: a meta-review of systematic reviews. Eur J Integr Med 2020:101252.
Panahi Y, Khalili N, Hosseini MS, Abbasinazari M, Sahebkar A. Lipid-modifying effects of adjunctive therapy with curcuminoids–piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complement Ther Med 2014;22(5):851-857.
Jamwal R. Bioavailable curcumin formulations. A review of pharmacokinetic studies in healthy volunteers. J Integr Med 2018;16(6):367-374.
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Atakan A, Kabaran S, Eren FH. The effects of dietary intervention with turmeric on lipid profile and anthropometric indices in overweight/obese women with hyperlipidemia: a randomized controlled clinical trial. Progr Nutr [Internet]. 2022 Dec. 23 [cited 2024 Nov. 5];24(4):e2022099. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/11815
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How to Cite
1.
Atakan A, Kabaran S, Eren FH. The effects of dietary intervention with turmeric on lipid profile and anthropometric indices in overweight/obese women with hyperlipidemia: a randomized controlled clinical trial. Progr Nutr [Internet]. 2022 Dec. 23 [cited 2024 Nov. 5];24(4):e2022099. Available from: https://mattioli1885journals.com/index.php/progressinnutrition/article/view/11815
