Correlations between insulin function and levels of adipocyte fatty acid-binding protein and serum uric acid in newly diagnosed type 2 diabetes mellitus patients with abdominal obesity

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Xiaowan Jiang
Sheng Ding


insulin; adipocyte fatty acid-binding protein; serum uric acid; type 2 diabetes mellitus; abdominal obesity


Objective: To study the correlations between insulin function and levels of adipocyte fatty acid-binding protein (A-FABP) and serum uric acid (SUA) in newly diagnosed type 2 diabetes mellitus (T2DM) patients with abdominal obesity. Methods: A total of 218 eligible patients were divided into abdominal obesity group (n=98) and non-abdominal obesity group (n=120) according to waist circumference. Their basic data, laboratory indices, levels of A-FABP and SUA, insulin resistance (IR) index [homeostasis model assessment of IR (HOMA-IR)] and insulin secretion index (HOMA-β) were compared. The correlations of HOMA-IR with A-FABP, SUA and HOMA-β were analyzed by Pearson’s test. The risk factors for IR were explored by logistic regression analysis. Results: Body mass index (BMI), waist circumference, waist-to-hip ratio, diastolic blood pressure and systolic blood pressure significantly increased in abdominal obesity group compared with those in non-abdominal obesity group (P<0.05). Compared with non-abdominal obesity group, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride (TG), total cholesterol, aspartate aminotransferase, alanine aminotransferase and fasting serum insulin significantly increased, while high-density lipoprotein cholesterol decreased (P<0.05) in abdominal obesity group. HOMA-IR, HOMA-β and levels of A-FABP and SUA were significantly higher in abdominal obesity group than those in non-abdominal obesity group (P<0.05). HOMA-IR was significantly positively correlated with A-FABP, SUA and HOMA-β (P<0.0001). BMI, TG, waist circumference, A-FABP and SUA were risk factors for IR (P<0.05). Conclusion: A-FABP and SUA levels significantly increase in newly diagnosed T2DM patients with abdominal obesity, being positively correlated with IR. They are risk factors for IR. Reducing fat and weight and controlling the levels of A-FABP and SUA may be able to relieve IR and to prevent T2DM complicated with abdominal obesity.


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