The Effects of Dietary Inositol on Dimensional Obsessive Compulsive Scale Score
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Keywords
Inositol, Obsessive Compulsive Disorder, Mediterranean Diet, Serotonin Receptor, Secondary messenger
Abstract
Objective: The aim of the study was to explain the relationship between obsessive and compulsive disorder scores of university students, inositol levels in their diet and Mediterranean diet compatibility and to use nutrients as a protective method for disease formation. Material and Methods: 168 volunteers from Tekirdağ Namık Kemal University School of Health, School of Health and Faculty of Medicine were subjected to a ‘nutritional habits form’ consisting of 13 questions, a ‘Mediterranean diet compliance scale’ consisting of 14 questions, a ‘nutrient consumption frequency questionnaire’ containing inositol-rich foods and a dimensional Obsessive Compulsive Disorder scale consisting of 20 questions in the 2019-2020 academic year. Results: Of the participants, 83.3% had a DOCS score below 40 while 16.7% had a score of 40 and above. Daily inositol intake was 1000 mg and more in the 63.1% of the participants and was below 1000 mg in 36.9%. A statistically significant relationship was found between the concerns about “germs and contamination,” “concerns about being responsible for harm, injury, or bad luck,” “concerns about symmetry, completeness, and the need for things to be ‘just right’” categories of the DOCS and the amount of daily inositol intake (p<0.05). It was also found that there was a significant relationship between the amount of daily inositol intake (>1000 mg or <1000 mg) and the differences in the DOCS score. The DOCS score increased when the amount of daily inositol amount was below 1000 mg and the score decreased when the amount of daily inositol amount was above 1000 mg; thus, they were negatively correlated (p<0.05; r=- 0.203). Of the participants, 93.5% were in the incompatible category of the Mediterranean Diet Compatibility Scale, and no significant relationship was found between the scale score and the amount of daily inositol intake and the DOCS score (p>0.05). Conclusion: It is considered that adding nutrition richer than inositol to the diet based on the energy need of the individuals might be preventative for Obsessive and Compulsive Disorder (OCD).
References
2. Berridge MJ. The inositol trisphosphate/calcium signaling pathway in health and disease. Physiological reviews. 2016;96(4):1261-96.
3. Harvey BH, Scheepers A, Brand L, Stein DJ. Chronic inositol increases striatal D2 receptors but does not modify dexamphetamine-induced motor behavior: Relevance to obsessive–compulsive disorder. Pharmacology Biochemistry and Behavior. 2001;68(2):245-53.
4. Fisher SK, Novak JE, Agranoff BW. Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. Journal of neurochemistry. 2002;82(4):736-54.
5. Kim H, McGrath BM, Silverstone PH. A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies. Human Psychopharmacology: Clinical and Experimental. 2005;20(5):309-26.
6. Nick GL. Inositol as a treatment for psychiatric disorders: a scientific evaluation of its clinical effectiveness. Townsend Letter for Doctors and Patients. 2004(255):51-4.
7. Seedat S, Stein D. Inositol augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: an open trial. International clinical psychopharmacology. 1999;14(6):353-6.
8. Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. Journal of clinical psychopharmacology. 2001;21(3):335-9.
9. Işgın K, Ayaz A. Polikistik Over Sendromu Tedavisinde İnositol Desteği. Beslenme ve Diyet Dergisi. 2015;43(1):71-7.
10. Clements Jr RS, Darnell B. Myo-inositol content of common foods: development of a high-myo-inositol diet. The American journal of clinical nutrition. 1980;33(9):1954-67.
11. Carlomagno G, Unfer V. Inositol safety: clinical evidences. Eur Rev Med Pharmacol Sci. 2011;15(8):931-6.
12. Pehlivanoğlu EFÖ, Balcıoğlu H, Ünlüoğlu İ. Akdeniz Diyeti Bağlılık Ölçeği’nin Türkçe’ye Uyarlanması Geçerlilik ve Güvenilirliği. Osmangazi Tıp Dergisi.42(2):160-4.
13. León-Munoz LM, Guallar-Castillón P, Graciani A, López-García E, Mesas AE, Aguilera MT, et al. Adherence to the Mediterranean diet pattern has declined in Spanish adults. The Journal of nutrition. 2012;142(10):1843-50.
14. Şafak Y, Öcal DS, Özdel K, Kuru E, Örsel S. Obsesif Kompülsif Bozuklukta Boyutsal Yaklaşım: Boyutsal Obsesif Kompülsif Bozukluk Ölçeği Türkçe’nin Psikometrik Özellikleri. Turk Psikiyatri Dergisi. 2018;29(2).
15. Rucklidge JJ, Kaplan BJ. Nutrition and mental health. Clinical Psychological Science. 2016;4(6):1082-4.
16. Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, et al. Physical activity, diet, and risk of Alzheimer disease. Jama. 2009;302(6):627-37.
17. Sánchez-Villegas A, Martínez-González MA, Estruch R, Salas-Salvadó J, Corella D, Covas MI, et al. Mediterranean dietary pattern and depression: the PREDIMED randomized trial. BMC medicine. 2013;11(1):208.
18. Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, De la Torre R, Martínez-González MÁ, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA internal medicine. 2015;175(7):1094-103.
19. Briguglio M, Dell’Osso B, Galentino R, Banfi G, Porta M. Higher adherence to the Mediterranean diet is associated with reduced tics and obsessive-compulsive symptoms: A series of nine boys with Obsessive-Compulsive Tic Disorder. Nutrition Clinique et Métabolisme. 2019;33(3):227-30.
20. Leppink EW, Redden SA, Grant JE. A double-blind, placebo-controlled study of inositol in trichotillomania. International Clinical Psychopharmacology. 2017;32(2):107-14.
21. Gelber D, Levine J, Belmaker R. Effect of inositol on bulimia nervosa and binge eating. International Journal of Eating Disorders. 2001;29(3):345-8.
22. Urrila AS, Hakkarainen A, Castaneda A, Paunio T, Marttunen M, Lundbom N. Frontal cortex Myo-inositol is associated with sleep and depression in adolescents: a proton magnetic resonance spectroscopy study. Neuropsychobiology. 2017;75(1):21-31.
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