Multivitamin with L-Arginine Supplementation Can Increase Linear Growth Velocity in Children with Idiopathic Short Stature without Affecting Bone Maturation L-arginine Supplemantation in Children with Idiopathic Short Stature
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Keywords
Idiopathic short stature; L-arginine supplementation; growth velocity
Abstract
L-arginine is a well-known growth hormone (GH) stimulator. The aim of the present study was to investigate the effect of L-arginine supplementation on growth velocity in prepubertal boys with idiopathic short stature. In this retrospectively designed study, prepubertal boys over 5 years of age who were diagnosed with idiopathic short stature were randomized into two groups according to their use of multivitamin with arginine (ARGİVİT®) (n=24) or multivitamin without arginine (n=34). Both groups were compared statistically according to growth velocity, IGF-1 and IGF-BP3 SDS and bone age maturation rates before and after 1 year of treatment. Basal IGF-1 SDS and basal IGF-BP3 SDS values of the groups were similar, but after the mean 1-year treatment, IGF-1 and IGFBP3 SDS values of the study group increased significantly compared to the control group. The annual growth velocity of the study group also showed a statistically significant increase compared to the control group. There was no statistical difference between the two groups in terms of bone maturation. L-arginine supplementation can be an inexpensive, safe and effective treatment alternative in idiopathic short stature.
References
2. Inzaghi E, Reiter E, Cianfarani S. The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy. Horm Res Paediatr 2019;92(2):71-83.
3. Oh HS, Oh SK, Lee JS, Wu C, Lee SJ. Effects of l-arginine on growth hormone and insulin-like growth factor 1. Food Sci Biotechnol 2017; 26(6):1749-54.
4. Wu D, Chen RM, Chen SK, Liu GL, Chen LQ, Yang Y, Wang XL, Peng YG, Gong CX. Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty. BMC Pediatr 2020; 20(1):138.
5. Greulich WW, Pyle SI. 1959 Radiographic atlas of skeletal development of the hand and the wrist, 2nd ed. Stanford: Stanford University Press.
6. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006; 95:1635-41.
7. Bereket A , Turan S , Omar A , Berber M , Ozen A , Akbenlioglu C , Haklar G . Serum IGF-I and IGFBP-3 levels of Turkish children during childhood and adolescence: establishment of reference ranges with emphasis on puberty. Horm Res 2006; 65:96-105.
8. Wu G, Ott TL, Knabe DA, Bazer FW. Amino acid composition of the fetal pig. J Nutr 1999; 129: 1031–8.
9. Wu G, Morris SM. Arginine metabolism: nitric oxide and beyond. Biochem J 1998; 336: 1–17.
10. Jiang MY, Cai DP (2011) Oral arginine improves linear growth of long bones and the neuroendocrine mechanism. Neurosci Bull 2011; 27:156–62.
11. van Vught AJ, Dagnelie PC, Arts IC, Froberg K, Andersen LB, El-Naaman B, Bugge A, Nielsen BM, Heitman BL. Dietary arginine and linear growth: the Copenhagen School Child Intervention Study. Br J Nutr 2013; 28: 109(6):1031-9.
12. Leibholz J. Arginine requirements of pigs between 7 and 28 days of age. Aust J Agric Res 1982; 33: 165–70.
13. Kim SW, Wu G. Dietary arginine supplementation enhances the growth of milk-fed young pigs. J Nutr 2004;134(3):625-30.
14. van Loon LJ, Saris WH, Verhagen H, et al. Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate. Am J Clin Nutr 2000; 72: 96–105.
15. van Loon LJ, Kruijshoop M, Menheere PP, et al. Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes. Diabetes Care 2003; 26: 625-30.
16. Wastney ME, Martin BR, Peacock M, et al. Changes in calcium kinetics in adolescent girls induced by high calcium intake. J Clin Endocrinol Metab 2000; 85: 4470–75.
17. Devine A, Rosen C, Mohan S, et al. Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. Am J Clin Nutr 1998; 68: 200–6.
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