Multivitamin with L-Arginine Supplementation Can Increase Linear Growth Velocity in Children with Idiopathic Short Stature without Affecting Bone Maturation L-arginine Supplemantation in Children with Idiopathic Short Stature

Main Article Content

Ömer Akcagil
Korkut Ulucan
Teoman Akçay


Idiopathic short stature; L-arginine supplementation; growth velocity


L-arginine is a well-known growth hormone (GH) stimulator. The aim of the present study was to investigate the effect of L-arginine supplementation on growth velocity in prepubertal boys with idiopathic short stature. In this retrospectively designed study, prepubertal boys over 5 years of age who were diagnosed with idiopathic short stature were randomized into two groups according to their use of multivitamin with arginine (ARGİVİT®) (n=24) or multivitamin without arginine (n=34). Both groups were compared statistically according to growth velocity, IGF-1 and IGF-BP3 SDS and bone age maturation rates before and after 1 year of treatment. Basal IGF-1 SDS and basal IGF-BP3 SDS values ​​of the groups were similar, but after the mean 1-year treatment, IGF-1 and IGFBP3 SDS values ​​of the study group increased significantly compared to the control group. The annual growth velocity of the study group also showed a statistically significant increase compared to the control group. There was no statistical difference between the two groups in terms of bone maturation. L-arginine supplementation can be an inexpensive, safe and effective treatment alternative in idiopathic short stature.


Download data is not yet available.
Abstract 5739 | PDF Downloads 862


1. Cohen P, Rogol AD, Deal CL, Saenger P, Reiter EO, Ross JL, et al.; 2007 ISS Consensus Workshop participants. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. J Clin Endocrinol Metab 2008;93(11):4210–7
2. Inzaghi E, Reiter E, Cianfarani S. The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy. Horm Res Paediatr 2019;92(2):71-83.
3. Oh HS, Oh SK, Lee JS, Wu C, Lee SJ. Effects of l-arginine on growth hormone and insulin-like growth factor 1. Food Sci Biotechnol 2017; 26(6):1749-54.
4. Wu D, Chen RM, Chen SK, Liu GL, Chen LQ, Yang Y, Wang XL, Peng YG, Gong CX. Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty. BMC Pediatr 2020; 20(1):138.
5. Greulich WW, Pyle SI. 1959 Radiographic atlas of skeletal development of the hand and the wrist, 2nd ed. Stanford: Stanford University Press.
6. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006; 95:1635-41.
7. Bereket A , Turan S , Omar A , Berber M , Ozen A , Akbenlioglu C , Haklar G . Serum IGF-I and IGFBP-3 levels of Turkish children during childhood and adolescence: establishment of reference ranges with emphasis on puberty. Horm Res 2006; 65:96-105.
8. Wu G, Ott TL, Knabe DA, Bazer FW. Amino acid composition of the fetal pig. J Nutr 1999; 129: 1031–8.
9. Wu G, Morris SM. Arginine metabolism: nitric oxide and beyond. Biochem J 1998; 336: 1–17.
10. Jiang MY, Cai DP (2011) Oral arginine improves linear growth of long bones and the neuroendocrine mechanism. Neurosci Bull 2011; 27:156–62.
11. van Vught AJ, Dagnelie PC, Arts IC, Froberg K, Andersen LB, El-Naaman B, Bugge A, Nielsen BM, Heitman BL. Dietary arginine and linear growth: the Copenhagen School Child Intervention Study. Br J Nutr 2013; 28: 109(6):1031-9.
12. Leibholz J. Arginine requirements of pigs between 7 and 28 days of age. Aust J Agric Res 1982; 33: 165–70.
13. Kim SW, Wu G. Dietary arginine supplementation enhances the growth of milk-fed young pigs. J Nutr 2004;134(3):625-30.
14. van Loon LJ, Saris WH, Verhagen H, et al. Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate. Am J Clin Nutr 2000; 72: 96–105.
15. van Loon LJ, Kruijshoop M, Menheere PP, et al. Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes. Diabetes Care 2003; 26: 625-30.
16. Wastney ME, Martin BR, Peacock M, et al. Changes in calcium kinetics in adolescent girls induced by high calcium intake. J Clin Endocrinol Metab 2000; 85: 4470–75.
17. Devine A, Rosen C, Mohan S, et al. Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. Am J Clin Nutr 1998; 68: 200–6.