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The Linear Non-threshold Extrapolation of Dose-Response Curves Is a Challenge for Managing the Risk Associated with Occupational Exposure to Carcinogenic Agents

Authors

  • Antonio Mutti Redazione LA MEDICINA DEL LAVORO Clinica del Lavoro "L. Devoto" Via S. Barnaba, 820122 Milano - tel. 02 503 20125 - fax 02 503 20126 - redazione@lamedicinadellavoro.it

DOI:

https://doi.org/10.23749/mdl.v114i1.14176

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Author Biography

Antonio Mutti, Redazione LA MEDICINA DEL LAVORO Clinica del Lavoro "L. Devoto" Via S. Barnaba, 820122 Milano - tel. 02 503 20125 - fax 02 503 20126 - redazione@lamedicinadellavoro.it

Tel. 02/50320125 - Fax 02/50320126

References

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Samet JM, Chiu WA, Cogliano V, et al. The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification. J Natl Cancer Inst. 2020;112(1):30-37. Doi: https://doi.org/10.1093/jnci/djz169

Nielsen GD, Øvrebø S, Background, approaches and recent trends for setting health-based occupational expo-sure limits: A mini review. Regul Toxicol Pharmacol. 2008;51:253-269.

McConnell EE, Solleveld HA, Swenberg JA, Boorman GA. Guidelines for Combining Neoplasms for Evaluation of Rodent Carcinogenesis Studies. J Natl Cancer Inst. 1986;76(2):283-289.

Calabrese EJ. The Gofman-Tamplin Cancer Risk Controversy and Its Impact on the Creation of BEIR I and the Acceptance of LNT. Med Lav. 2023;114(1):xxx.

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EFSA (European Food Safety Authority), 2005: Opinion of the Scientific Committee on a request from EFSA re-lated to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA Journal, 282,1-31. http://www.efsa.europa.eu/en/efsajournal/pub/282 (accessed Jan 5, 2023).

Aleksunes LM, Eaton DL. Principles of Toxicology in Casarett & Doull's Toxicology: The Basic Science of Poisons. Ninth Edition., New York: McGraw-Hill Education, 2019, pp. 25-64.

Calabrese EJ, Baldwin LA. Chemical hormesis: its historical foundations as a biological hypothesis.D. 1999 Mar-Apr;27(2):195-216. Doi: 10.1177/019262339902700207.

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EFSA Scientific Committee, More S, Benford D, et al. Opinion on the impact of non-monotonic dose responses on EFSA′s human health risk assessments. EFSA J. 2021;19(10):6877. Doi:https://doi.org/10.2903/j.efsa.2021.6877).

Saracci R. The hazards of hazard identification in environmental epidemiology. Environ Health. 2017;16(1):85. Doi: 10.1186/s12940-017-0296-3

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Issue

Vol. 114 No. 1 (2023)

Section

Editorial

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