Linear Non-Threshold (LNT) historical discovery milestones

Authors

  • Edward Calabrese

DOI:

https://doi.org/10.23749/mdl.v113i4.13381

Keywords:

LNT, cancer risk assessment, ionizing radiation, dose response, hormesis, linear non-threshold, mutations, DNA repair, scientific misconduct, history of science

Abstract

The present paper provides a summarized identification of critical historical milestones in the discovery of the flawed and corrupt foundations of cancer risk assessment, with particular focus on the LNT Dose Response model. The milestone sequence presented herein is based on a large body of published findings by the author. The history of LNT and cancer response represents what may be the most significant case of scientific misconduct reported in the US, with its revelation severely damaging the scientific credibility and moral authority of leading US regulatory agencies and organizations such as the National Academy of Sciences (NAS) and the journal Science. The consequences of this corrupt history are substantial, affecting cancer risk assessment throughout the world, critical aspects of national economies, the development of critical technologies and public health practices.

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References

Muller HJ. The method of evolution. Sci Mon. 1929;29,481-505.

Calabrese EJ. Muller’s Nobel Prize data: Getting the dose wrong and its significance. Environ Res. 2019; 176, 108528.

Muller HJ. Artificial transmutation of the gene. Science. 1927;66,84-87.

Stadler LJ. The gene. Science. 1954;120,811-819.

Calabrese EJ. The linear no-threshold (LNT) dose response model: A comprehensive assessment of its historical and scientific foundation. Chem-Biol Inter. 2019;301,6-25.

Ducoff HS. Radiation hormesis: incredible or inevitable. Korean J Biol Sci. 2002;6,187-193.

Muller HJ. Radiation and genetics. Amer Nat. 1930;64,220-251.

Lefevre G, Jr. A comparison of x-ray induced generic effects in germinal and somatic tissue of Drosophila melanogaster. Degree of Doctor of Philosophy, Graduate School of the University of Missouri, Columbia, Missouri, 1949.

Lefevre G, Jr. X-ray induced genetic effects in germinal and somatic tissue of Drosophila melanogaster. Amer Nat. 1950;84,341-365.

Ray-Chaudhuri SP. The validity of the Bunsen-Roscoe law in the production of mutations by radiation of extremely low intensity. Proc R Soc Edin. 1944;62,66-72.

Calabrese EJ. Key studies to support cancer risk assessment questioned. Environ Mol Mut. 2011;52(8) 595-606.

Calabrese EJ. How the US National Academy of Sciences misled the world community on cancer risk assessment: new findings challenge historical foundations of the linear dose response. Arch Toxicol. 2013;87 2063-2081.

Calabrese EJ. On the origins of the linear no-threshold (LNT) dogma by means of untruths, artful dodges and blind faith. Environ Res. 2015;142,432-442.

Calabrese EJ. Ethical failures: The problematic history of cancer risk assessment. Environ Res. 2020;193,110582T.

Caspari E, Stern C. The influence of chronic irradiation with gamma-rays at low dosages on the mutation rate in Drosophila melangogaster. Genetics. 1948;33,75-95.

Spencer WP, Stern C. Experiments to test the validity of the linear R-dose mutation frequency relation in drosophila at low dosage. Genetics. 1948;33,43-74.

Muller HJ. The production of mutations. Nobel Lecture, 1946. Nobleprize.org (http:www.nobelprize.org/nobel-prizes/medicine/laureates/1946). 1946.

Calabrese EJ. Muller’s Nobel Prize lecture: When ideology prevailed over science. Tox Sci. 2012;126(1),1-4.

Uphoff D, Stern C. The genetic effects of low intensity irradiation. Science. 1949;109,609-610.

Muller HJ. Radiation damage to the genetic material. Amer Sci. 1950;38,32-59.

Muller HJ. Some present problems with genetic effects of radiation. J Cell Comp Physiol. 1950;35,9-70.

Muller HJ. The manner of production of mutations by radiation. 1. In: Radiation Biology, High Energy Radiation, Editor Hollaender A; McGraw Hill Book Company, New York NY. 1954; Volume 1, pp. 475-626.

Evans RD. Quantitative inferences concerning the genetic effects of radiation on human beings. Science. 1949;109,299-304.

Creager AN. Radiation, cancer and mutation in the atomic age. Hist Stud Nat Sci. 2015;45,14-48.

Medical Research Council (MRC). Medical Research Council’s Report. In: Hazards of Radiation. London, England. 1956.

National Academy of Sciences (NAS)/National Research Council (NRC). The Biological Effects of Atomic Radiation (BEAR): A report to the public. Washington, DC, NAS/NRC. 1956.

Calabrese EJ, Giordano J. Ethical issues in the US 1956 National Academy of Sciences BEAR I genetics panel report to the public. Health Physics 2022; (in press).

Calabrese EJ. The Muller-Neel dispute and the fate of cancer risk assessment. Environ Res. 2020;190,109961.

Calabrese EJ. LNT and cancer risk assessment: Its flawed foundations, Part 1: Radiation and leukemia: Where LNT began. Environ Res. 2021;197,111025.

Calabrese EJ. LNT and cancer risk assessment: Its flawed foundation, Part 2: How unsound LNT science became accepted. Environ Res. 2021;197,111041.

DuShane G. Loaded dice. Science. 1957;125,964.

Lewis EB. Leukemia and ionizing radiation. Science. 1957;125,965-972.

NCRPM (National Committee on Radiation Protection and Measurement). Somatic radiation dose for the general population. Report of the Ad Hoc Committee of the NCRPM, May 6. Science. 1960;131(3399),482-486.

Cosgrove GE, Selby PB, Upton A, Russell WL. Lifespan and autopsy findings in the 1st generation offspring of Z-irradiated male mice. Mut Res. 1993;319,71-79.

Calabrese EJ, Selby P. Cover up and cancer risk assessment: Prominent US scientists suppressed evidence to promote adoption of LNT. Environ Res. 2022;210,112973.

Russell WL, Russell LB, Kelly EM. Radiation dose rate and mutation frequency. Science. 1958;128(3338),1546-1550.

Russell WL. Mutagenesis in the mouse and its application to the estimation of the genetic hazards of radiation. In: Advances in Radiation Research, Biology and Medicine; Editors JF Duplan, A Chapiro; Gordon and Breach Science Publishers, New York NY, 1973, pp. 323-334.

Selby PB. The Selby-Russell dispute regarding the non-reporting of critical data in the mega-mouse experiments of D. William and Liane Russell that spanned many decades: What happened, current status, and some ramifications. Dose Response 2020; 18, 1559325819900714.

Russell LB, Russell WL. Spontaneous mutations recovered as mosaics in the mouse specific-locus test. Proc Natl Acad Sci. USA 1996;93,13072-13077.

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Published

25-08-2022

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Reviews, Commentaries, Perspectives