Secondary effects resulting from hormone therapy on the quality of life and sexuality: analysis of the effectiveness of the use of specific dermatological products

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Lucia Bonassi
Agostino Brugnera
Antonino Latona
Giuseppe Nastasi
Federica Ruffini
Katy Cuffaro
Valentina Sarchi
Angelo Compare


Dermocosmetological treatments, Breast Cancer, urogenital symptoms, hormone therapy


Background. Breast Cancer (BC) treatments could determine urogenital symptoms which can impact negatively on sexual function and quality of life (QoL) and reduce compliance to therapy of the cancer woman.

Aim. The aim of the study is to investigate the impact of secondary effects on the urogenital system resulting from hormone therapy on the quality of life of cancer women; in particular, this study wants to evaluate if a specific dermatological treatment could reduce secondary effects of hormone therapy on the urogenital system and consequently improve women’s sexuality and quality of life (QoL).

Methods. Forty-nine women with BC were recruited. The women were divided into two groups and randomized in Experimental (EG) and Control Group (CG). For 42 days, EG use a specific dermatological treatment, while CG use a non-specific treatment. Participants were asked to performed 3 self-report instruments (Analogue scales for detecting the following symptoms, K10, WHOQoL-Brief) at three points: at baseline (T0), after 21 days (T1) and after 21 days (T2) from enrolment.

Results. The specific dermatological treatment in the EG was associated with statistically significant decreases in vaginal pain, vaginal burning, vaginal itching, vaginal dryness and with a statistically significant increase in QoL, after 42 days (T2).

Conclusions. The use of specific dermatological products decreases urogenital symptoms caused by hormone therapy and increase, consequently, the quality in sexual function and quality of life of women with breast cancer (QoL).

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