Peripheral ameloblastoma: case report and our experience 20 years

Fabio Luciani; Edoarto Papa; Andrea Leggeri; Roberta Condò; Filippo Giovannetti; Leonardo Calabrese

doi:10.23750/abm.v94iS1.13527

Peripheral ameloblastoma: case report and our experience 20 years

Authors

Fabio Luciani 1. DDS, PhD, Catholic University “Our Lady of Good Counsel” – Tirana, Albania
Edoarto Papa 2. University of Roma “Tor Vergata” – U.O. Oral-Maxillofacial Surgery, Post Graduate Course in “Oral Surgery”. Director and Chief: Prof. Leonardo Calabrese
Andrea Leggeri 2. University of Roma “Tor Vergata” – U.O. Oral-Maxillofacial Surgery, Post Graduate Course in “Oral Surgery”. Director and Chief: Prof. Leonardo Calabrese https://orcid.org/0000-0003-0927-4254
Roberta Condò 2. University of Roma “Tor Vergata” – U.O. Oral-Maxillofacial Surgery, Post Graduate Course in “Oral Surgery”. Director and Chief: Prof. Leonardo Calabrese
Filippo Giovannetti 3. University of L’Aquila - Director and Chief U.O.S.D. Maxillofacial Surgery P.O. L’Aquila
Leonardo Calabrese 2. University of Roma “Tor Vergata” – U.O. Oral-Maxillofacial Surgery, Post Graduate Course in “Oral Surgery”. Director and Chief: Prof. Leonardo Calabrese

DOI: https://doi.org/10.23750/abm.v94iS1.13527

Keywords:

Odontogenic Tumors, OdontogPeripheral Ameloblastoma, Oral Biopsies

Abstract

Background and aim: The purpose of this study was to determine the clinical and histological features and treatment of peripheral ameloblastoma. Peripheral Ameloblastoma is a rare benign odontogenic tumor that concerns soft tissue and have a typical extraosseous localization.

Methods: Aim of this work is to show its clinical and histological characters, in order to define some useful information for differential diagnosis with other oral neoformations, comparing literature with our data, collected in ten years of clinical activity of Oral and Maxillofacial Surgery Unit of Policlinico Tor Vergata in Rome.

Results: Prognosis of PA is certainly favourable, with a restitutio ad integrum close to 100%. In the period between October 2011 and November 2021, we reported 8 diagnoses of P.A. Medium age of the group with diagnosis of PA was 71,4 y with a SD: 3,65. P.A.’s incidence in our sample of patients was 0,26%.

Conclusions: PA is a benign odontogenic tumor that requires a careful diagnosis, a complete surgical eradication and adequate follow up, because malignant evolution is rare but possible.

References

Chae MP, Smoll NR, Hunter-Smith DJ, Rozen WM. Establishing the natural history and growth rate of ameloblastoma with implications for management: systematic review and meta-analysis. PLoS One. 2015 Feb 23;10(2):e0117241.

Renapurkar SK, Broccoli P, Carrico C, Glass S. Are incisional biopsies reliable for selecting definitive treatment of ameloblastomas? A 15-year interdisciplinary retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Apr;133(4):388-395.

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. World Health Organization classification of head and neck tumours. World Health Organization classification of head and neck tumours. 4th Lyon: International Agency for Research on Cancer; 2017:217-218.

Vanoven BJ, Parker NP, Petruzzelli GJ et al. Peripheral ameloblastoma of the maxilla: a case report and literature review. Am J Otolaryngol- Head and Neck Medicine and Surgery 2008;29:357-360.

Kuru H. Ueber das Adamantinom. Zentralbl Allg Pathol.1911;22:291-295

Gardner DG. Some current concepts on the pathology of ameloblastomas. Oral Surg Oral Med Oral Pathos 1996;82:660-669.

Shetty K. Peripheral ameloblastoma: an etiology from surface epithelium? Case report and reviw of literature. Oral Oncol Extra 2005;41:211-215.

Gardner DG, Heikinheimo K, Shear M, Philipsen HP, Coleman HA. World Health Organization Classification of Tumours. Pathology and Genetics Head and Neck Tumors (2005).

LeCorn DW, Bhattacharyya I, Vertucci FJ. Peripheral Ameloblastoma: a case report and review of the literature J Endod. 2006;32(2):152-154.

Martelli JH, Souza LN, Santos LAN et al. Peripheral Ameloblastoma:a case report. Oral Surg Oral Med Pathos Oral Radiol Endod 2005;99:E31-33

Yamanishi T, Ando S, Aikawa T. et al. A case of extragingival peripheral ameloblastoma in the buccal mucosa. J.Oral Pathos Med 2007;36:184-186

Kishino M, Muratami S, Yuki M et al. A immunohistochemical study of the peripheral ameloblastoma. Oral Diseases 2007;13:575-580

Tsjima Y, Kuroda-Kawasaki M, Ohno J, et al. Peripheral ameloblastoma with potentially malignant features: report of case with special regard to its keratin profile. J. Oral Pathos Med 2001;30:494-498.

Philipsen HP, Reichart PA, Nikai H. et al. Peripheral ameloblastoma: biological profile based on 160 cases from the literature. Oral Oncol 2001;37:17-27

Mintz S, Anavi Y, Sabes WR. Peripheral ameloblastoma of gthe gengiva. A case report. J Periodontol 1990;61:649-652.

Manor Y, Mardinger O, Katz J, et al. Peripheral odontogenic tumours-differential diagnosis in gingival lesions. Int J. Oral Maxillofac Surg 2004;33:268-27.

Nauta JM, Panders AK, Schoots CJF, et al. Peripheral ameloblastoma: a case report and reviw of the literature. J. Oral Maxilllofac Surg 1992;21:40-44.

Cavallotti C, Giovannetti F, Cavallotti C, Iannetti G. Vascular wall of head-facial hemangioma. J Craniofac Surg. 2011 May;22(3):1052-5.

Wettan HL, Patella PA, Freedman PD. Peripheral ameloblastoma reviw of the literature and report of recurrence as severe dyspasia. J. Oral Maxillofac Surg 2001;59:811-815.

Baden E., Doyle JL, Petriella V. Malignant transformation of peripheral ameloblastoma. Oral Surg Oral Med Oral Pathol 1993;75:214-219.

Anpalagan A, Tzortzis A, Twigg J, Wotherspoon R, Chengot P, Kanatas A. Current practice in the management of peripheral ameloblastoma: a structured review. Br J Oral Maxillofac Surg. 2021 Jan;59(1):e1-e8.