United airway disease
Keywords:
united airway disease, rhinitis, asthma, children, allergy, IgE, aeroallergen, COVID-19Abstract
Nose and lungs are considered as anatomic and functional unit, as they share morphological, pathophysiological and immunological basis. Allergic rhinitis and asthma often coexist in the same individual, and the treatment of one also improves the symptoms of the other (one airway, one disease). The aim of this review is to discuss the interaction between upper and lower airways, based on recent scientific evidence and, critically, analyze the important implications the new findings have for the future therapy and prevention of these common diseases.
References
Passalacqua G, Ciprandi G, Canonica GW. The nose-lung interaction in allergic rhinitis and asthma: united airways disease. CurrOpin Allergy Clin Immunol 2001;1:7–13.
Grossman J. One airway, one disease. Chest 1997;11:11S–6S.
Yii ACA, Tay TR, Choo XN, Koh MSY, Tee AKH, Wang DY. Precision medicine in united airways disease: A "treatable traits" approach. Allergy 2018;73:1964-1978.
Ciprandi G, Caimmi D, Miraglia Del Giudice M, La Rosa M, Salpietro C, Marseglia GL. Recent developments in United airways disease. Allergy Asthma Immunol Res 2012;4:171-7.
Mastrorilli C, Posa D, Cipriani F, Caffarelli C. Asthma and allergic rhinitis in childhood: what's new. Pediatr Allergy Immunol 2016;27:795-803.
Caimmi D, Marseglia A, Pieri G, Benzo S, Bosa L, Caimmi S. Nose and lungs: one way, one disease. Ital J Pediatr 2012;38:60.
Saheb Sharif-Askari N, Saheb Sharif-Askari F, Alabed M, et al. Airways expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 is lower in children than adults and increases with smoking and COPD. Mol Ther Methods Clin Dev 2020;18:1-6.
Parisi GF, Brindisi G, Indolfi C, et al. Upper airway involvement in pediatric COVID-19. Pediatr Allergy Immunol 2020;31 Suppl 26(Suppl 26):85-88.
Asher MI, Keil U, Anderson HR, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995;8:483-91.
Shaaban R, Zureik M, Soussan D, et al. Allergic rhinitis and onset of bronchial hyperresponsiveness: a population-based study. Am J Respir Crit Care Med 2007;176:659-66.
Tohidinik HR, Mallah N, Takkouche B. History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis. World Allergy Organ J 2019;12:100069.
Rochat MK, Illi S, Ege MJ, et al. Allergic rhinitis as a predictor for wheezing onset in school-aged children. J Allergy Clin Immunol 2010;126:1170-5.e2.
Cruz AA, Popov T, Pawankar R, et al. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA (2) LEN. Allergy 2007;62(suppl):1-41.
Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010;126:466–476.
Gough H, Grabenhenrich L, Reich A, et al. Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS. Pediatr Allergy Immunol 2015;26:431-7
Ponte EV, Franco R, Nascimento HF, et al. Lack of control of severe asthma is associated with co-existence of moderate-to-severe rhinitis. Allergy 2008;63:564-9.
Benazzo M, Leonardi S, Corsico A, et al. Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: a pilot study. Acta Biomed 2020;92:e2021003.
Bresciani M, Paradis L, Des Roches A, et al. Rhinosinusitis in severe asthma. J Allergy Clin Immunol 2001;107:73-80.
Burgess JA, Walters EH, Byrnes GB, et al. Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study. J Allergy Clin Immunol 2007;120:863–9.
González Hernández J, Gómez Vera J, Orea Solano M, Flores Sandoval G, Ríos Nava R, de la Torre F. Hiperrespuesta de las víasaéreasen los pacientes con rinitisalérgica y no alérgica [Airway hyperreactivity in patients with allergic and non-allergic rhinitis]. Rev Alerg Mex 2003;50:86-90.
Ciprandi G, Tosca MA, Cirillo I, Capasso M. Impact of allergic rhinitis on asthma in children: effects on bronchial hyperreactivity. Allergy 2010;65:1199-201.
Ciprandi G, Cirillo I, Tosca MA, Vizzaccaro A. Bronchial hyperreactivity and spirometric impairment in patients with perennial allergic rhinitis. Int Arch Allergy Immunol 2004;133:14-8.
Chawes BL. Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis. Dan Med Bull 2011;58:B4278.
Chawes BL, Bønnelykke K, Kreiner-Møller E, Bisgaard H. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol 2010;126:567-73.
Bousquet J, Schünemann HJ, Togias A, et al. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol 2020;145:70-80.
Camargos P, Ibiapina C, Lasmar L, Cruz AA. Obtaining concomitant control of allergic rhinitis and asthma with a nasally inhaled corticosteroid. Allergy 2007;62:310-6.
Greisner WA, Settipane RJ, Settipane GA. The course of asthma parallels that of allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc 2000;21:371–5.
De Vittori V, Pacilio A, Indinnimeo L, et al. When asthma and rhinitis coexist, could rhinitis reduce asthma control in children? Allergy Asthma Proc 2019;40:e8-e13.
Camargos P, Ibiapina C, Lasmar L, Cruz AA. Obtaining concomitant control of allergic rhinitis and asthma with a nasally inhaled corticosteroid. Allergy. 2007;62:310-6.
Morjaria JB, Caruso M, Emma R, Russo C, Polosa R. Treatment of allergic rhinitis as a strategy for preventing asthma. Curr Allergy Asthma Rep 2018;18:23.
Caffarelli C, Mastrorilli C, Procaccianti M, Santoro A. Use of sublingual immunotherapy for aeroallergens in children with asthma. J Clin Med 2020;9:3381.
Novembre E, Galli E, Landi F, et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 2004;114:851-7.
Valdesoiro L, Bosque M, Marco MT, Asensio O, Antón J, Larramona H. Rinitisalérgica e hiperreactividadbronquial [Allergic rhinitis and bronchial hyperreactivity]. AllergolImmunopathol (Madr) 2004;32:340-3.
Chanez P, Vignola AM, Vic P, et al. Comparison between nasal and bronchial inflammation in asthmatic and control subjects. Am J Respir Crit Care Med 1999;159:588-95
Ballardini N, Bergström A, Wahlgren CF, et al. IgE antibodies in relation to prevalence and multimorbidity of eczema, asthma, and rhinitis from birth to adolescence. Allergy 2016;71:342-9.
Amorim MM, Araruna A, Caetano LB, Cruz AC, Santoro LL, Fernandes AL. Nasal eosinophilia: an indicator of eosinophilic inflammation in asthma. Clin Exp Allergy 2010;40:867-74.
Togias A. Rhinitis and asthma: evidence for respiratory system integration. J Allergy Clin Immunol 2003;111:1171-83.
Braunstahl GJ. United airways concept: what does it teach us about systemic inflammation in airways disease? Proc Am Thorac Soc 2009;6:652-4.
Kanda A, Kobayashi Y, Asako M, Tomoda K, Kawauchi H, Iwai H. Regulation of interaction between the upper and lower airways in united airway disease. Med Sci (Basel) 2019;7:27.
Togias A. Mechanisms of nose-lung interaction. Allergy 1999;54 Suppl 57:94-105.
Pastacaldi C, Lewis P, Howarth P. Staphylococci and staphylococcal superantigens in asthma and rhinitis: a systematic review and meta-analysis. Allergy 2011;66:549-55.
Skylogianni E, Triga M, Douros K, et al. Small-airway dysfunction precedes the development of asthma in children with allergic rhinitis. AllergolImmunopathol (Madr) 2018;46:313-321.
Miraglia del Giudice M, Capasso M, Maiello N, et al. Exhaled nitric oxide and atopy in children. J Allergy Clin Immunol 2003;111:193.
Poddighe D, Brambilla I, Licari A, Marseglia GL. Pediatric rhinosinusitis and asthma. Respir Med 2018;141:94-99.
Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United airway disease: current perspectives. J Asthma Allergy 2016;9: 93-100.
Kanda A, Kobayashi Y, Asako M, Tomoda K, Kawauchi H, Iwai H. Regulation of interaction between the upper and lower airways in united airway disease. Med Sci (Basel) 2019;7:27
Miraglia Del Giudice M, Parisi GF, Indolfi C, et al. Nasal microbiome in chronic rhinosinusitis. Minerva Pediatr 2020. Online ahead of print.
Huang YJ, Nelson CE, Brodie EL, et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol 2011;127:372-381.e1-3.
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