The GLAD Lesion: are the definition, diagnosis and treatment up to date? A Systematic Review.
Keywords:
GLAD, cartilage defects, GlenoLabral Articular DisruptionAbstract
Introduction: Although GLAD lesions are quite common, only sporadic case reports describe surgical techniques and clinical outcomes. Even if cartilage defects can result from various pathogenic mechanisms, the resulting defect has some similarities with GLAD, and its management can be a starting point to treat both types of lesion. Aim of the present study is to find a commonly accepted definition for GLAD lesions in order to understand its pathogenesis, diagnosis and possible treatments. Methods: A search of PubMed (MEDLINE) database has been performed in June 2020 to identify relevant articles including a combination of the following search terms: “GlenoLabral Articular Disruption” OR "GLAD" AND "shoulder" AND "cartilage, articular". Results: Abstract evaluation included 31 articles in the full-text review. Various studies showed that the performance of MR arthrography in the detection of glenohumeral cartilage lesions, including GLAD lesions, was moderate. Different therapeutic solutions have been described. Arthroscopic debridement of the lesion and reattachment of the labrum have been often used. In case of large articular defects, the labrum could be advanced in the cartilage defect to cover it. In case of cartilage flap with reparable margins, this could be reattached with different suture constructs. Neglected GLAD lesions following a chronic trauma or shoulder instability have not been described in literature. Conclusions: The definition of GLAD injury has changed over the time. Many authors associate this lesion with shoulder instability, with trauma in abduction and extra rotation, while Neviaser's original definition described stable shoulders following a trauma in adduction.
References
Neviaser TJ. The GLAD lesion: Another cause of anterior shoulder pain. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 1993;9(1):22-23. doi:10.1016/S0749-8063(05)80339-1
Amrami KK, Sperling JW, Bartholmai BJ, Sundaram M. Radiologic case study. Glenolabral articular disruption (GLAD) lesion. Orthopedics. 2002;25(1):29, 95-96.
Antonio GE, Griffith JF, Yu AB, Yung PSH, Chan KM, Ahuja AT. First-time shoulder dislocation: High prevalence of labral injury and age-related differences revealed by MR arthrography. J Magn Reson Imaging. 2007;26(4):983-991. doi:10.1002/jmri.21092
Page R, Bhatia DN. Arthroscopic repair of a chondrolabral lesion associated with anterior glenohumeral dislocation. Knee Surg Sports Traumatol Arthrosc. 2010;18(12):1748-1751. doi:10.1007/s00167-010-1095-3
Zhu W, Lu W, Zhang L, et al. Arthroscopic findings in the recurrent anterior instability of the shoulder. Eur J Orthop Surg Traumatol. 2014;24(5):699-705. doi:10.1007/s00590-013-1259-1
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement | Systematic Reviews | Full Text. Accessed July 16, 2020. https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/2046-4053-4-1
Sanders TG, Tirman PF, Linares R, Feller JF, Richardson R. The glenolabral articular disruption lesion: MR arthrography with arthroscopic correlation. American Journal of Roentgenology. 1999;172(1):171-175. doi:10.2214/ajr.172.1.9888763
Singh RB, Hunter JC, Smith KL. Mri of shoulder instability: state of the art. Current Problems in Diagnostic Radiology. 2003;32(3):127-134. doi:10.1016/S0363-0188(03)00014-8
O’Brien J, Grebenyuk J, Leith J, Forster BB. Frequency of glenoid chondral lesions on MR arthrography in patients with anterior shoulder instability. European Journal of Radiology. 2012;81(11):3461-3465. doi:10.1016/j.ejrad.2012.05.013
Galano GJ, Weisenthal BM, Altchek DW. Articular Shear of the Anterior-Inferior Quadrant of the Glenoid: A Glenolabral Articular Disruption Lesion Variant. :3.
Lederman ES, Flores S, Stevens C, Richardson D, Lund P. The Glenoid Labral Articular Teardrop Lesion: A Chondrolabral Injury With Distinct Magnetic Resonance Imaging Findings. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2018;34(2):407-411. doi:10.1016/j.arthro.2017.08.236
Guntern DV, Pfirrmann CWA, Schmid MR, et al. Articular cartilage lesions of the glenohumeral joint: diagnostic effectiveness of MR arthrography and prevalence in patients with subacromial impingement syndrome. Radiology. 2003;226(1):165-170. doi:10.1148/radiol.2261012090
Waldt S, Burkart A, Imhoff AB, Bruegel M, Rummeny EJ, Woertler K. Anterior Shoulder Instability: Accuracy of MR Arthrography in the Classification of Anteroinferior Labroligamentous Injuries. Radiology. 2005;237(2):578-583. doi:10.1148/radiol.2372041429
Rhee YG, Lim CT. Glenoid defect associated with anterior shoulder instability: results of open Bankart repair. Int Orthop. 2007;31(5):629-634. doi:10.1007/s00264-006-0234-4
Ruckstuhl H, de Bruin ED, Stussi E, Vanwanseele B. Post-traumatic glenohumeral cartilage lesions: a systematic review. BMC Musculoskelet Disord. 2008;9(1):107. doi:10.1186/1471-2474-9-107
Elser F, Braun S, Dewing CB, Millett PJ. Glenohumeral Joint Preservation: Current Options for Managing Articular Cartilage Lesions in Young, Active Patients. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2010;26(5):685-696. doi:10.1016/j.arthro.2009.10.017
Pogorzelski J, Fritz EM, Horan MP, Katthagen JC, Provencher MT, Millett PJ. Failure following arthroscopic Bankart repair for traumatic anteroinferior instability of the shoulder: is a glenoid labral articular disruption (GLAD) lesion a risk factor for recurrent instability? Journal of Shoulder and Elbow Surgery. 2018;27(8):e235-e242. doi:10.1016/j.jse.2018.02.055
Englund M, Lohmander LS. Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis & Rheumatism. 2004;50(9):2811-2819. doi:10.1002/art.20489
Agarwalla A, Puzzitiello RN, Leong NL, Forsythe B. Concurrent Primary Repair of a Glenoid Labrum Articular Disruption and a Bankart Lesion in an Adolescent: A Case Report of a Novel Technique. Case Reports in Orthopedics. 2019;2019:1-6. doi:10.1155/2019/4371860
Seidl AJ, Kraeutler MJ. Management of Articular Cartilage Defects in the Glenohumeral Joint: Journal of the American Academy of Orthopaedic Surgeons. 2018;26(11):e230-e237. doi:10.5435/JAAOS-D-17-00057
McCarty LP, Cole BJ. Nonarthroplasty Treatment of Glenohumeral Cartilage Lesions. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2005;21(9):1131-1142. doi:10.1016/j.arthro.2005.06.023
Millett PJ, Huffard BH, Horan MP, Hawkins RJ, Steadman JR. Outcomes of Full-Thickness Articular Cartilage Injuries of the Shoulder Treated With Microfracture. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2009;25(8):856-863. doi:10.1016/j.arthro.2009.02.009
Frank RM, Van Thiel GS, Slabaugh MA, Romeo AA, Cole BJ, Verma NN. Clinical Outcomes after Microfracture of the Glenohumeral Joint. Am J Sports Med. 2010;38(4):772-781. doi:10.1177/0363546509350304
Wang KC, Frank RM, Cotter EJ, et al. Long-term Clinical Outcomes After Microfracture of the Glenohumeral Joint: Average 10-Year Follow-up. Am J Sports Med. 2018;46(4):786-794. doi:10.1177/0363546517750627
Shin JJ, Mellano C, Cvetanovich GL, Frank RM, Cole BJ. Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation. Arthroscopy Techniques. 2014;3(4):e519-e522. doi:10.1016/j.eats.2014.05.014
Wang VM, Karas V, Lee AS, et al. Assessment of glenoid chondral healing: comparison of microfracture to autologous matrix-induced chondrogenesis in a novel rabbit shoulder model. Journal of Shoulder and Elbow Surgery. 2015;24(11):1789-1800. doi:10.1016/j.jse.2015.06.008
Scheibel M, Bartl C, Magosch P, Lichtenberg S, Habermeyer P. Osteochondral autologous transplantation for the treatment of full-thickness articular cartilage defects of the shoulder. J Bone Joint Surg Br. 2004;86(7):991-997. doi:10.1302/0301-620x.86b7.14941
Kircher J, Patzer T, Magosch P, Lichtenberg S, Habermeyer P. Osteochondral autologous transplantation for the treatment of full-thickness cartilage defects of the shoulder: results at nine years. J Bone Joint Surg Br. 2009;91(4):499-503. doi:10.1302/0301-620X.91B4.21838
Riff AJ, Yanke AB, Shin JJ, Romeo AA, Cole BJ. Midterm results of osteochondral allograft transplantation to the humeral head. J Shoulder Elbow Surg. 2017;26(7):e207-e215. doi:10.1016/j.jse.2016.11.053
DiPaola MJ, Jazrawi LM, Rokito AS, et al. Management of humeral and glenoid bone loss--associated with glenohumeral instability. Bull NYU Hosp Jt Dis. 2010;68(4):245-250.
Romeo AA, Cole BJ, Mazzocca AD, Fox JA, Freeman KB, Joy E. Autologous chondrocyte repair of an articular defect in the humeral head. Arthroscopy. 2002;18(8):925-929. doi:10.1053/jars.2002.36144
Buchmann S, Salzmann GM, Glanzmann MC, Wörtler K, Vogt S, Imhoff AB. Early clinical and structural results after autologous chondrocyte transplantation at the glenohumeral joint. J Shoulder Elbow Surg. 2012;21(9):1213-1221. doi:10.1016/j.jse.2011.07.030
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