Correlation analysis of Insulin-like Growth Factor-1 level on severity in ischemic stroke patients: A cross-sectional study

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Correlation analysis of Insulin-like Growth Factor-1 level on severity in ischemic stroke patients: A cross-sectional study

Authors

  • Irwansyah Fitri Latif Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Andi Kurnia Bintang Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia; Hasanuddin University Hospital, Makassar, South Sulawesi, Indonesia https://orcid.org/0000-0001-7010-4065
  • Muhammad Akbar Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia; Hasanuddin University Hospital, Makassar, South Sulawesi, Indonesia
  • Nadra Maricar Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Mochammad Erwin Rachman Department of Neurology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, South Sulawesi, Indonesia
  • Andi Alfian Zainuddin Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Ashari Bahar Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia; Hasanuddin University Hospital, Makassar, South Sulawesi, Indonesia; Division of Neurointervention and Endovascular Therapy, Brain Center, Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi, Indonesia https://orcid.org/0000-0001-8994-1816
  • Wijoyo Halim Division of Neurointervention and Endovascular Therapy, Brain Center, Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi, Indonesia; Department of Neurology, Faculty of Medicine, Alkhairaat University, Palu, Central Sulawesi, Indonesia

Keywords:

ischemic stroke, severity, NIHSS, IGF-1

Abstract

Background and aim: Our knowledge of the pathophysiology of stroke and its treatment strategies has greatly benefited from the application of biomarkers in the area. Insulin-like growth factor-1 (IGF-1), a neuroprotectant, is one likely biomarker for predicting the outcome of stroke. With its neuroprotective properties, IGF-1 is a potential biomarker for stroke prognostic prediction. The aim of this study to ascertain the relationship of serum IGF-1 levels with the severity of ischemic stroke patients.

Methods: This cross-sectional study involved 62 acute ischemic stroke patients and 21 normal controls. The study was conducted during October-November 2024 at several hospitals in Makassar, Indonesia. The assessment of serum IGF-1 concentrations and the assessment of stroke severity utilizing the National Institutes of Health Stroke Scale (NIHSS) were performed at the time of admission.

Results: Most of the ischemic stroke patients were male (54.8%) with a mean age of 57.91 ± 9.41 years. Most of the acute ischemic stroke samples had moderate severity stroke (51.6%). IGF-1 levels in acute ischemic stroke patients were significantly lower than the normal population of the same age, with mean IGF-1 levels of 0.420 ± 0.157 and 1.265 ± 2.653, respectively (p=0.007). There was no significant relationship between serum IGF-1 levels and stroke severity or fasting blood glucose levels at the beginning of admission.

Conclusions: IGF-1 levels are lower in ischemic stroke patients compared to the normal population, and there is no correlation between serum IGF-1 levels and stroke severity at the time of admission.

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How to Cite

1.
Latif IF, Bintang AK, Akbar M, et al. Correlation analysis of Insulin-like Growth Factor-1 level on severity in ischemic stroke patients: A cross-sectional study. Acta Biomed. 96(4):16717. doi:10.23750/abm.vi.16717

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Section

ORIGINAL CLINICAL RESEARCH

How to Cite

1.
Latif IF, Bintang AK, Akbar M, et al. Correlation analysis of Insulin-like Growth Factor-1 level on severity in ischemic stroke patients: A cross-sectional study. Acta Biomed. 96(4):16717. doi:10.23750/abm.vi.16717