Intrauterine transmission of COVID-19 in Pregnancy: case report and review of literature

Main Article Content

Deena Elkafrawi
Julie Joseph
Antonio Schiattarella
Brian Rodriguez
Giovanni Sisti


pregnancy, neonate, covid19, sars-cov2, fetus


We report the first case of SARS-CoV-2 pregnancy in the U.S. Our literature review highlights the rarity of COVID-19 intrauterine transmission and the need for clinicians to promptly test neonates born to SARS-CoV-2 positive mothers at delivery for COVID-19. It is imperative to establish the real risk of intrauterine transmission and to develop appropriate preventive and treatment strategies.



Download data is not yet available.


Metrics Loading ...
Abstract 327 | PDF Downloads 144


1. Palacios Cruz, M.; Santos, E.; Velázquez Cervantes, M.A.; León Juárez, M. COVID-19, a worldwide public health emergency. Rev. Clin. Esp. 2020, doi:10.1016/j.rce.2020.03.001.
2. Chen, D.; Yang, H.; Cao, Y.; Cheng, W.; Duan, T.; Fan, C.; et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID‐19) infection. Int. J. Gynecol. Obstet. 2020, 149, 130–136, doi:10.1002/ijgo.13146.
3. Liu, H.; Wang, L.-L.; Zhao, S.-J.; Kwak-Kim, J.; Mor, G.; Liao, A.-H. Why are pregnant women susceptible to COVID-19? An immunological viewpoint. J. Reprod. Immunol. 2020, 139, 103122, doi:10.1016/j.jri.2020.103122.
4. Erlebacher, A. Mechanisms of T cell tolerance towards the allogeneic fetus. Nat. Rev. Immunol. 2012, 13, 23–33, doi:10.1038/nri3361.
5. Guerin, L.R.; Prins, J.R.; Robertson, S.A. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum. Reprod. Update 2009, 15, 517–535, doi:10.1093/humupd/dmp004.
6. Perrone, S.; Deolmi, M.; Giordano, M.; D’Alvano, T.; Gambini, L.; Corradi, M.; et al. Report of a series of healthy term newborns from convalescent mothers with COVID-19. Acta Biomed. 2020, 91, 251–255, doi:10.23750/abm.v91i2.9743.
7. Liu, Y.; Chen, H.; Tang, K.; Guo, Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J. Infect. 2020, S0163-4453(20)30109–2, doi:10.1016/j.jinf.2020.02.028.
8. Fan, C.; Lei, D.; Fang, C.; Li, C.; Wang, M.; Liu, Y.; et al. Perinatal Transmission of COVID-19 Associated SARS-CoV-2: Should We Worry? Clin. Infect. Dis. 2020, ciaa226, doi:10.1093/cid/ciaa226.
9. Zhu, H.; Wang, L.; Fang, C.; Peng, S.; Zhang, L.; Chang, G.; et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl. Pediatr. 2020, 9, 51–60, doi:10.21037/tp.2020.02.06.
10. Wang, X.; Zhou, Z.; Zhang, J.; Zhu, F.; Tang, Y.; Shen, X. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin. Infect. Dis. 2020, ciaa200, doi:10.1093/cid/ciaa200.
11. Li, Y.; Zhao, R.; Zheng, S.; Chen, X.; Wang, J.; Sheng, X.; et al. Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China. Emerg. Infect. Dis. 2020, 26, 1335–1336, doi:10.3201/eid2606.200287.
12. Zeng, L.; Xia, S.; Yuan, W.; Yan, K.; Xiao, F.; Shao, J.; et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. 2020, e200878, doi:10.1001/jamapediatrics.2020.0878.