A Thyroid Stimulating Hormone Reference Range: Iranian Thyroid Cohort study TSH and reference range

Main Article Content

rokhsareh meamar
awat feizi
Ashraf Aminorroaya
Massoud Amini
Maryam nasri
Azamosadat Tabatabaei
Majid Abyar

Keywords

: Reference range, TSH, Antithyroid antibodies, Iran

Abstract

 


Background: Current reference values for thyroid function tests are based on data from different ethnicities and geographical areas. Therefore, our aim was to select criteria from the guidelines proposed by the National Academy of Clinical Biochemistry (NACB) and to determine the TSH and T4 reference limits in the iodine-sufficient area of Isfahan, a metropolitan city in Iran.


Materials and methods: This study was conducted within the framework of “Isfahan Thyroid Study (ITS)” an ongoing prospective cohort that started in 2006 (n=2523) until 2011 (n=711) and included participants above the age of twenty. We measured TSH, T4, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb).


Results: Based on the NACB criteria, 1899 participants were included in 2006(58.5% male) and 377 in 2011(62.3% male). The mean± SD age was 39.66 ±12.71 and 48.96±12.35 in 2006 and 2011, respectively.


The mean± SD for TSH was 2.0±1.19 and 2.11±1.11 mU/l and T4 was 6.67±1.47 and 8.3±2.95 μg /dl in 2006 and 2011, respectively.


In 2006, the 2.5th percentile of serum TSH levels was 0.4 mU/l (males: 0.4 mIU/L, females: 0.5 mIU/L) and the 97.5th percentile of serum TSH was 4.96 mU/l (males: 4.72 mU/l, females: 5. 3 mU/l). In 2011, the 2.5th percentile of serum TSH levels was 0.7 mU/l( males: 0.6 mIU/L, females: 0.77 mIU/L) and 97.5th percentiles  of serum TSH was 4.9 mU/l(males: 5.7 mU/l,  females :5. 57 mU/l).


Conclusion: This study determined age and sex specific TSH and T4 reference ranges in the Isfahanian population, which could theoretically enable clinicians to classify patients more accurately.

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