Smell and taste dysfunction during the COVID-19 outbreak: a preliminary report

Smell and taste dysfunction during the COVID-19 outbreak: a preliminary report


  • Matteo Gelardi
  • Eleonora Trecca
  • Michele Cassano
  • Giorgio Ciprandi


COVID-19, anosmia, dysgeusia, respiratory symptoms.


In late December 2019, in Wuhan (China), health authorities reported several clusters of pneumo- nia of unknown cause, subsequently attributed to a novel coronavirus, identified as Severe Acute Respiratory Syndrome-Coronavirus 2. Anosmia and dysgeusia have been reported as particular symptoms.4,5  Notably, these sensory symptoms seem to have a peculiar trend, such as usually precede the onset of respiratory symp- toms. So, they have been defined as “sentinel” symptoms. We presented a series of COVID-19 patients. Anos- mia and dysgeusia frequently preceded respiratory complaints. Anosmia and dysgeusia seem to be short-lived and self-resolving in COVID-19, thus a neurotoxic effect swiftly disappearing and/or cytopathic damage could be hypothesized similarly to other viral infections.


Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020; 382:727-733.

World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020.

Vukkadala N, Qian ZJ, Holsinger FC, Patel ZM, Rosenthal E. COVID-19 and the otolaryngologist – preliminary evidence-based review. Laryngoscope 2020 (in press)

Joshi A, Rao G. Coronavirus: Expert says new symptoms could be loss of taste or smell. Sky News. taste-or-smell-11961439. Published March 21, 2020.

Hopkins C, Kumar N. Loss of sense of smell as marker of COVID-19 infection. ENT UK. Published in 2020. Accessed March 30, 2020.

Gelardi M, Piccininni K, Quaranta N, Quaranta V, Silvestri M, Ciprandi G. Olfactory dysfunction in patients with chronic rhinosinusitis with nasal polyps is associated with Clinical-Cytological Grading severity. Acta ORL Italica 2019;39:329-35

Joseph T, Auger SD, Peress L, Rack D, Cuzick J, Giovannoni G, et al. Screening Performance of Abbreviated Versions of the UPSIT Smell Test. J Neurol 2019;266:1897-1906

Kim SJ, Windon MJ, Lin SY. The Association Between Diabetes and Olfactory Impairment in Adults: A Systematic Review and Meta-Analysis. Laryngoscope Investig Otolaryngol 2019;4:465-75

Gelardi M, Ciprandi G. Nasal Cytology identifies healthy and damaged nasal epithelial cells. Acta Biomedica 2020;19:148-9







How to Cite

Smell and taste dysfunction during the COVID-19 outbreak: a preliminary report. Acta Biomed [Internet]. 2020 May 11 [cited 2024 Jun. 18];91(2):230-1. Available from:

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