OSTEOCLAST - LIKE GIANT CELL UNDIFERRENTIATED PANCREATIC TUMOR DIAGNOSED BY MEANS OF EUS GUIDED FNA

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Janis Mouzas
ALEXANDRA KALOGERAKI
Ioannis Koutroubakis
Eleni Moustou
Eleni Lappa
Dimitrios Tamiolakis
Angelici Machaira
Eleni Orfanoudaki
Evangelos Kalaitzakis

Keywords

KEY WORDS Undifferentiated osteoclast like giant cell pancreatic tumour, Cytology, EUS-FNA, Cell block, Immunocytology

Abstract

ABSTRACT


Objective


Osteoclast-like giant cell tumours are rare abdominal malignant neoplasms mainly arising


in the pancreas. Because of their rarity, clinical and cytopathology reports are very


 


limited, and sonographic features have not been clearly specified ; these tumors are


 


easily misdiagnosed by ultrasound as mucinous cystic tumors (MCTs)  or solid


 


pseudopapillary neoplasms (SPNs).


 


Case study


 


We report a case of osteoclast  like giant cell tumor


 


arising in the pancreas of an 80 year old female patient offered by EUS-FNA cytology


 


on direct and cell block slides. A biphasic pattern composed by a malignant


 


mononuclear cell component and a giant cell component were hallmarks to the


 


diagnosis.


 


Conclusion.


 


Our case highlights the performance of EUS-FNA in the diagnostic


 


approach of  abdominal tumours and the significance of cell block method in the


 


interpretation of osteoclast-like giant cell pancreatic tumour

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