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KEY WORDS Undifferentiated osteoclast like giant cell pancreatic tumour, Cytology, EUS-FNA, Cell block, Immunocytology
Osteoclast-like giant cell tumours are rare abdominal malignant neoplasms mainly arising
in the pancreas. Because of their rarity, clinical and cytopathology reports are very
limited, and sonographic features have not been clearly specified ; these tumors are
easily misdiagnosed by ultrasound as mucinous cystic tumors (MCTs) or solid
pseudopapillary neoplasms (SPNs).
We report a case of osteoclast like giant cell tumor
arising in the pancreas of an 80 year old female patient offered by EUS-FNA cytology
on direct and cell block slides. A biphasic pattern composed by a malignant
mononuclear cell component and a giant cell component were hallmarks to the
Our case highlights the performance of EUS-FNA in the diagnostic
approach of abdominal tumours and the significance of cell block method in the
interpretation of osteoclast-like giant cell pancreatic tumour
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