The prevalence of hypomagnesemia in a representative population from northeastern Iran

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Majid Ghayour Mobarhan
Majid Gohari-Kahou
Maryam Saberi karimian
elham barati
hamideh Qazizadeh
ali javandoust
mohammad safarian
mohsen mouhebati
mahmoud ebrahimi
Gordon A.Ferns
hamid reza kazerani


Magnesium; BMI; Cardiovascular disease


Background: Magnesium (Mg2+) is an important cation involved in several biochemical and physiological functions. It plays a key role in the activity of enzymes involved in the metabolism of carbohydrates, lipids and proteins. Hypomagnesemia (a low value of serum magnesium) has been reported in metabolic syndrome, diabetes and cardiovascular disease. In the current study we have assessed the prevalence of the hypomagnesemia among Iranian adults. Methods: A total of 853 participants were recruited as part of the MASHAD study, a cohort study of subjects (aged 35-65 years) .The subjects were divided into three age groups:  35-44.9, 45-54.9 and 55-64.9 years old. Anthropometric indices including weight and height were measured by standard methods. Serum Mg concentrations were measured using fasting blood samples, taken from all participants and were measured using the xylidyl blue photometric method (Pars Azmoon kit; Tehran, Iran) on a BT3000 auto analyser. Data analyzes were performed using SPSS version 20 (Chicago-USA). A p-value less than 0.05 was considered statistically significant. Results: In the study population, the mean serum Mg concentration was 1.03±0.16 mg/dl. The prevalence of a low serum magnesium (defined as magnesium <0.94 mg/dl) was 25.8%, 23.13% and 28.1%, in the total population, and in men, and women respectively. There was no significant difference in serum Mg level between men and women (P>0.05). Moreover, there were no significant differences in the prevalence of low value of serum magnesium and serum Mg concentrations in total population, males and females for the three age groups (P<0.05). There was not a significant difference between mg level and anxiety and depression scores in different groups of sex and age. After adjusting for confounding factors, there was a significant association between BMI and % body fat with serum Mg level (P<0.05). Conclusions: The prevalence of the low value of serum magnesium was 25.8% in northeastern Iran. There was a significant association between a low serum magnesium level and BMI and % body fat.


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