Mechanisms of hypersensitivity reactions induced by drugs

Fabrizio Franceschini; Paolo Bottau; Silvia Caimmi; Fabio Cardinale; Giuseppe Crisafulli; Lucia Liotti; Francesca Saretta; Roberto Bernardini; Francesca Mori; Carlo Caffarelli

doi:10.23750/abm.v90i3-S.8160

Mechanisms of hypersensitivity reactions induced by drugs

Authors

Fabrizio Franceschini UOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Ancona, Italy
Paolo Bottau Pediatric and Neonatology Unit, Imola Hospital, Imola (BO), Italy
Silvia Caimmi Pediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
Fabio Cardinale UOC di Pediatria, Azienda Ospedaliera-Universitaria “Consorziale-Policlinico”, Ospedale Pediatrico Giovanni XXIII, Bari, Italy
Giuseppe Crisafulli UO Allergologia, Dipartimento di Pediatria, Università di Messina, Italy
Lucia Liotti Department of Pediatrics, Senigallia Hospital, Senigallia, Italy
Francesca Saretta Pediatric Department, AAS2 Bassa Friulana-Isontina, Palmanova-Latisana, Italy; Pediatric Allergy Unit, Department of Medicine, Udine, Italy
Roberto Bernardini Pediatric Unit, “San Giuseppe” Hospital, Empoli, Italy
Francesca Mori Allergy Unit, Department of Pediatric Medicine, Anna Meyer Children’s University Hospital, Florence, Italy
Carlo Caffarelli Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy

Keywords:

Drug allergy, prevention, beta lactam hypersensitivity, NSAIDs hypersensitivity, hypersensitivity reactions, children, skin test, specific IgE, drug provocation test

Abstract

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.

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Published

28-01-2019

Issue

Vol. 90 No. 3-S (2019): Advances in pediatric drug allergy - Guest Editor: Carlo Caffarelli

Section

REVIEWS

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

Franceschini F, Bottau P, Caimmi S, et al. Mechanisms of hypersensitivity reactions induced by drugs. Acta Biomed. 2019;90(3-S):44-51. doi:10.23750/abm.v90i3-S.8160

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