Mechanisms of hypersensitivity reactions induced by drugs

Mechanisms of hypersensitivity reactions induced by drugs


  • Fabrizio Franceschini UOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Ancona, Italy
  • Paolo Bottau Pediatric and Neonatology Unit, Imola Hospital, Imola (BO), Italy
  • Silvia Caimmi Pediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  • Fabio Cardinale UOC di Pediatria, Azienda Ospedaliera-Universitaria “Consorziale-Policlinico”, Ospedale Pediatrico Giovanni XXIII, Bari, Italy
  • Giuseppe Crisafulli UO Allergologia, Dipartimento di Pediatria, Università di Messina, Italy
  • Lucia Liotti Department of Pediatrics, Senigallia Hospital, Senigallia, Italy
  • Francesca Saretta Pediatric Department, AAS2 Bassa Friulana-Isontina, Palmanova-Latisana, Italy; Pediatric Allergy Unit, Department of Medicine, Udine, Italy
  • Roberto Bernardini Pediatric Unit, “San Giuseppe” Hospital, Empoli, Italy
  • Francesca Mori Allergy Unit, Department of Pediatric Medicine, Anna Meyer Children’s University Hospital, Florence, Italy
  • Carlo Caffarelli Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy


Drug allergy, prevention, beta lactam hypersensitivity, NSAIDs hypersensitivity, hypersensitivity reactions, children, skin test, specific IgE, drug provocation test


Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.




How to Cite

Franceschini F, Bottau P, Caimmi S, Cardinale F, Crisafulli G, Liotti L, et al. Mechanisms of hypersensitivity reactions induced by drugs. Acta Biomed [Internet]. 2019 Jan. 28 [cited 2024 Jul. 14];90(3-S):44-51. Available from: