Mechanisms of hypersensitivity reactions induced by drugs

Fabrizio Franceschini; Paolo Bottau; Silvia Caimmi; Fabio Cardinale; Giuseppe Crisafulli; Lucia Liotti; Francesca Saretta; Roberto Bernardini; Francesca Mori; Carlo Caffarelli

doi:10.23750/abm.v90i3-S.8160

Fabrizio Franceschini

UOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Ancona, Italy

Paolo Bottau

Pediatric and Neonatology Unit, Imola Hospital, Imola (BO), Italy

Silvia Caimmi

Pediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

Fabio Cardinale

UOC di Pediatria, Azienda Ospedaliera-Universitaria “Consorziale-Policlinico”, Ospedale Pediatrico Giovanni XXIII, Bari, Italy

Giuseppe Crisafulli

UO Allergologia, Dipartimento di Pediatria, Università di Messina, Italy

Lucia Liotti

Department of Pediatrics, Senigallia Hospital, Senigallia, Italy

Francesca Saretta

Pediatric Department, AAS2 Bassa Friulana-Isontina, Palmanova-Latisana, Italy; Pediatric Allergy Unit, Department of Medicine, Udine, Italy

Roberto Bernardini

Pediatric Unit, “San Giuseppe” Hospital, Empoli, Italy

Francesca Mori

Allergy Unit, Department of Pediatric Medicine, Anna Meyer Children’s University Hospital, Florence, Italy

Carlo Caffarelli

Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy

Keywords

Drug allergy, prevention, beta lactam hypersensitivity, NSAIDs hypersensitivity, hypersensitivity reactions, children, skin test, specific IgE, drug provocation test

Abstract

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.

Downloads

Download data is not yet available.

Abstract 581 | PDF Downloads 257

PDF

Published

Jan 28, 2019

DOI https://doi.org/10.23750/abm.v90i3-S.8160

How to Cite

Franceschini F, Bottau P, Caimmi S, Cardinale F, Crisafulli G, Liotti L, Saretta F, Bernardini R, Mori F, Caffarelli C. Mechanisms of hypersensitivity reactions induced by drugs. Acta Biomed [Internet]. 2019 Jan. 28 [cited 2023 Mar. 21];90(3-S):44-51. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/8160

Issue

Vol. 90 No. 3-S (2019): Advances in pediatric drug allergy - Guest Editor: Carlo Caffarelli

Section

REVIEWS

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.