Diagnosis of GERD in typical and atypical manifestations

Silvia Cesario; Serena Scida; Chiara Miraglia; Alberto Barchi; Antonio Nouvenne; Gioacchino Leandro; Tiziana Meschi; Gian Luigi de' Angelis; Francesco Di Mario

doi:10.23750/abm.v89i8-S.7963

Diagnosis of GERD in typical and atypical manifestations

Authors

Silvia Cesario Department of Medicine and Surgery, University of Parma, Parma, Italy
Serena Scida Department of Medicine and Surgery, University of Parma, Parma, Italy
Chiara Miraglia Department of Medicine and Surgery, University of Parma, Parma, Italy
Alberto Barchi Department of Medicine and Surgery, University of Parma, Parma, Italy
Antonio Nouvenne Department of Medicine and Surgery, University of Parma, Parma, Italy
Gioacchino Leandro National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
Tiziana Meschi Department of Medicine and Surgery, University of Parma, Parma, Italy
Gian Luigi de' Angelis Department of Medicine and Surgery, University of Parma, Parma, Italy
Francesco Di Mario Department of Medicine and Surgery, University of Parma, Parma, Italy

DOI: https://doi.org/10.23750/abm.v89i8-S.7963

Keywords:

GERD, diagnosis, typical manifestations, atypical manifestations, pH impedance, gastrin 17

Abstract

The manifestations of gastroesophageal reflux disease (GERD) have been recently classified into either esophageal or extra-esophageal syndromes. Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD. Endoscopy had a low sensitivity. Recently, the availability of multichannel intraluminal impedance and pH-monitoring (MII-pH) has modified the diagnostic approach towards atypical manifestations of GERD. There is a rising consensus that this technique should be considered as the gold standard for GERD diagnosis. Gastrin 17 (G-17) has been proposed as a non-invasive marker of GERD, due to the negative feedback between acid and the hormone. G17 levels seem able to identify patients with acid and non-acid reflux.

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Published

17-12-2018

Issue

Vol. 89 No. 8-S (2018): Topics in Gastroenterology - Focus on Upper GI diseases - vol. 1 - Editors: Francesco Di Mario, Chiara Miraglia, Gian Luigi de’ Angelis, Federica Gaiani

Section

REVIEWS

License

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to Cite

Cesario S, Scida S, Miraglia C, et al. Diagnosis of GERD in typical and atypical manifestations. Acta Biomed. 2018;89(8-S):33-39. doi:10.23750/abm.v89i8-S.7963

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