Diagnostic techniques and multidisciplinary approach in idiopathic granulomatous mastitis: a revision of the literature

Diagnostic techniques and multidisciplinary approach in idiopathic granulomatous mastitis: a revision of the literature

Authors

  • Carolina Maione “P.GIACCONE” University Hospital, Palermo, Italy
  • Vincenzo Davide Palumbo University of Palermo Euro-Mediterranean Institute of Science and Technology, Palermo, Italy
  • Angela Maffongelli University of Palermo
  • Giuseppe Damiano University of Palermo
  • Salvatore Buscemi University of Palermo
  • Gabriele Spinelli University of Palermo
  • Salvatore Fazzotta University of Palermo
  • Eliana Gulotta University of Palermo
  • Giuseppe Buscemi University of Palermo
  • Attilio Ignazio Lo Monte University of Palermo

Keywords:

Breast cancer, Chronic benign inflammatory disease, Idiopatic mastitis

Abstract

Idiopathic granulomatous mastitis (IGM) is a chronic benign inflammatory disease of the breast that may mimic breast cancer. It is most common in parous young fertile women, although it can occur in nulliparous women and in men. IGM is an idiopathic disease due to the influence of some environmental factors in genetically predisposed subjects. Several pathogenic hypothesis have been proposed in the last years (autoimmune, hormonal, infective genesis). IGM presents as a painful palpable mass located in one of the two udders. The skin is usually normal but could present signs of inflammation with or without lymph nodes involvement. Ultrasonography, mammography, magnetic resonance can be diagnosed an IGM, but pathognomonic radiological signs has not yet reported in literature. Biopsy findings show granulomatous lesion centered on the breast lobule, as in granulomatous mastitis induced by tuberculosis or sarcoidosis. The aim of this review of literature is to verify the development of new advanced diagnostic techniques and multidisciplinary approach for this condition. In the last years innovative approaches have modified IGM diagnosis and therapy, avoiding surgery in most of cases, introducing a more conservative medical approach based on recent etiopathological hypothesis.

Author Biographies

Vincenzo Davide Palumbo, University of Palermo Euro-Mediterranean Institute of Science and Technology, Palermo, Italy

Department of Surgical, Oncological and Stomatological Disciplines

 

Angela Maffongelli, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

Giuseppe Damiano, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

Salvatore Buscemi, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

Gabriele Spinelli, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

Salvatore Fazzotta, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

Eliana Gulotta, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

Giuseppe Buscemi, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

Attilio Ignazio Lo Monte, University of Palermo

Department of Surgical, Oncological and Stomatological Disciplines

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Published

23-01-2019

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Section

REVIEWS

How to Cite

1.
Diagnostic techniques and multidisciplinary approach in idiopathic granulomatous mastitis: a revision of the literature. Acta Biomed [Internet]. 2019 Jan. 23 [cited 2024 Mar. 29];90(1):11-5. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/6607