The role of FFR in clinical decision making in patients with moderate coronary lesions: a pilot study

The role of FFR in clinical decision making in patients with moderate coronary lesions: a pilot study

Authors

  • Morteza Safi Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Ali Mehrabi Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Saeed Alipour Parsa Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Isa Khaheshi Cardiovascular Research Center, Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammadreza Naderian Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.

Keywords:

Fractional Flow Reserve, Myocardial, Coronary Vessels, Cost-Benefit Analysis, Percutaneous Coronary Intervention, Coronary Artery Bypass

Abstract

Background and Aim: Applying fractional flow reserve (FFR) recently helped to assess borderline coronary defects and also facilitates assessment of these lesions. The present study aimed to assess cost-effectiveness of FFR in detection of these borderline lesions. Methods: This cross-sectional study was conducted on140 consecutive patients with 219 diseased arteries who underwent coronary angiography and suffered intermediate coronary lesions. Results: Of 18 patients who candidate for CABG before FFR, only one patient underwent CABG after determining FFR (P-value<0.05), while 15 patients were scheduled for PCI and 2 patients for medical treatment. Of 122 patients who candidate for PCI, 59 were programmed to underwent PCI after FFR determination(P-value<0.05), while the strategy in 63 patients (47 with one-vessel disease, 15 with two vessel diseases, and 1 with three vessel diseases) was modified to medical treatment. Considering strategy modifying from PCI to medical treatment, 101 stents were saved (P-value<0.05). Also, in change of strategy from CABG to PCI, spending has decreased as much as 77.3% (P-value<0.05). Furthermore, the change of treatment approach from PCI on much number of coronary vessels to PCI on less number of coronary lesions led to saving of 52.2% of costs(P-value<0.05). Conclusions: In patients with an intermediate coronary lesion, measuring FFR to guide the decision to determine treatment strategy may lead to significant cost savings.

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Published

08-10-2018

Issue

Section

ORIGINAL ARTICLES

How to Cite

1.
The role of FFR in clinical decision making in patients with moderate coronary lesions: a pilot study. Acta Biomed [Internet]. 2018 Oct. 8 [cited 2024 Apr. 18];89(3):378-81. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/5605

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