A neuroleptic malignant-like syndrome (NMLS) in a patient with Parkinson’s disease resolved with rotigotine: a case report

A neuroleptic malignant-like syndrome (NMLS) in a patient with Parkinson’s disease resolved with rotigotine: a case report

Authors

  • Stefania Fiore INI Divisione Città Bianca, Casa di cura privata accreditata con il SSN, Via Foiano, 4 – 03020 – Veroli (Fr), Italy
  • Lidia Persichino , U.O.Medicina Interna Azienda Unità Sanitaria Frosinone Ospedale Civile Santa Scolastica di Cassino Località San Pasquale, 03043 Cassino (FR), Italy
  • Sabrina Anticoli U.O.C. Stroke Unit Azienda Ospedaliera San Camillo/Forlanini Circonvallazione Gianicolense 87 - 00152 Roma Phone: +39 06 58704349
  • Maria Francesca De Pandis Responsabile - Centro per la cura e la prevenzione del Parkinson - Centro per la cura e la diagnosi del Parkinson Clinica San Raffaele Cassino Via G. Di Biasio, 1 03043 Cassino (FR) Phone: +39 0776 3941

Keywords:

Neuroleptic Malignant-Like Syndrome (NMLS), Parkinson’s disease, Rotigotine

Abstract

Neuroleptic Malignant-Like Syndrome (NMLS) is a rare, but potentially fatal complication of dopaminergic therapy in Parkinson’s disease due to a sudden withdrawal of dopaminergic therapy. Here, we describe the case of a 79 years old woman, with 19 years history of Parkinson disease treated with L-dopa, dopamine agonists and MAO inhibitors, whose sudden withdrawal due to lack of therapeutic compliance, led to sudden onset of high fever, muscle rigidity, akinesia, autonomic dysfunction, impaired level of consciousness, respiratory distress and dysphagia with inability to take oral dopaminergic therapy. High blood levels of CPK and myoglobinaemia were found. The patient was treated with transdermal Rotigotine starting from a dose of 2 mg/24 hours, that was rapidly increased to 6 mg/24 hours, leading to resolution of the acute disturbances.

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Published

17-12-2014

How to Cite

1.
A neuroleptic malignant-like syndrome (NMLS) in a patient with Parkinson’s disease resolved with rotigotine: a case report. Acta Biomed [Internet]. 2014 Dec. 17 [cited 2024 Apr. 14];85(3):281-4. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/3990