Thyroid dysfunction and associated risk factors among type 2 diabetic patients: a cross-sectional study
Thyroid dysfunction and associated risk factors in type 2 diabetics
Keywords:
Hypothyroidism; Predictors; Risk factors; Cross-sectional study; Prevalence; ObesityAbstract
Background and aim: The link between diabetes and thyroid dysfunction has been established. Thus, the current study was carried out to estimate the prevalence of thyroid dysfunction, specifically hypothyroidism, and predictors of thyroid disorders in type 2 diabetes mellitus (T2DM) patients in Jordan. Research design and methods: In this cross-sectional observational study, 552 T2DM patients attending the Diabetes Center in Amman were included and underwent investigations for thyroid function. Information on demographics and risk factors for thyroid dysfunction was collected. Weight, height, and waist circumference were measured. All the patient-related biochemical data were extracted from their medical records. Patients were divided into three groups: those with euthyroidism, those with hypothyroidism (both established [old]s and new cases), and those with hyperthyroidism. P <0.05 was considered statistically significant. Results: The prevalence of hypothyroidism among T2DM was 21.0%. Hypothyroidism was significantly more common in females (26.1%) than in males (15.1%) (P = 0.002). There is a significantly higher proportion of diabetic patients who have hypothyroidism (38.2%) had a history of hypertension than those with euthyroidism (26.6%) (P = 0.035). Significant risk factors for hypothyroidism were BMI (OR 1.29 with 95% CI (1.056–1.577)), P= 0.013. Furthermore, the BMI cutoff value for predicting hypothyroidism in T2DM patients was more than 32.2 [(AUC) (95% CI (0.523–0.609)), P = 0.034]. Nevertheless, there were no significant associations between hypothyroidism and diabetes duration or HbA1C. Conclusion: Hypothyroidism is common among Jordanian diabetic patients. Obesity among the female gender could be an indicator for detecting hypothyroidism in T2DM patients.
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Copyright (c) 2024 Amjad Al Shdaifat, Manar Atoum, Huda Al Hourani, Muwafag Al Hyari, Joseph A. Abulail, Iyad khalifah ahmad aldomi, Dina Hani Haddad, Ahmad Agil
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