Thyroid dysfunction and associated risk factors among type 2 diabetic patients: a cross-sectional study: Thyroid dysfunction and associated risk factors in type 2 diabetics

Thyroid dysfunction and associated risk factors among type 2 diabetic patients: a cross-sectional study

Thyroid dysfunction and associated risk factors in type 2 diabetics

Authors

  • Amjad Al Shdaifat The Hashemite University, Zarqa, Jordan https://orcid.org/0000-0001-7082-4601
  • Huda Al Hourani The Hashemite University, Zarqa, Jordan https://orcid.org/0000-0001-7017-6499
  • Manar Atoum The Hashemite University, Zarqa, Jordan
  • Muwafag Al Hyari Prince Hamza Hospital, Diabetic Center, Amman, Jordan
  • Joseph A. Abulail The Hashemite University, Zarqa, Jordan
  • Iyad Khalifah Ahmad Aldomi Prince Hamza Hospital, Diabetic Center, Amman, Jordan
  • Dina Hani Haddad Prince Hamza Hospital, Diabetic Center, Amman, Jordan
  • Ahmad Agil University of Granada, Granada, Spain

Keywords:

Hypothyroidism; Predictors; Risk factors; Cross-sectional study; Prevalence; Obesity

Abstract

Background and aim: The link between diabetes and thyroid dysfunction has been established. Thus, the current study was carried out to estimate the prevalence of thyroid dysfunction, specifically hypothyroidism, and predictors of thyroid disorders in type 2 diabetes mellitus (T2DM) patients in Jordan. Research design and methods: In this cross-sectional observational study, 552 T2DM patients attending the Diabetes Center in Amman were included and underwent investigations for thyroid function. Information on demographics and risk factors for thyroid dysfunction was collected. Weight, height, and waist circumference were measured. All the patient-related biochemical data were extracted from their medical records. Patients were divided into three groups: those with euthyroidism, those with hypothyroidism (both established [old]s and new cases), and those with hyperthyroidism. P <0.05 was considered statistically significant. Results: The prevalence of hypothyroidism among T2DM was 21.0%. Hypothyroidism was significantly more common in females (26.1%) than in males (15.1%) (P = 0.002). There is a significantly higher proportion of diabetic ­patients who have hypothyroidism (38.2%) had a history of hypertension than those with euthyroidism (26.6%) (P = 0.035). Significant risk factors for hypothyroidism were BMI (OR 1.29 with 95% CI (1.056–1.577)), P= 0.013. Furthermore, the BMI cutoff value for predicting hypothyroidism in T2DM patients was more than 32.2 [(AUC) (95% CI (0.523–0.609)), P = 0.034]. Nevertheless, there were no significant associations between hypothyroidism and diabetes duration or HbA1C. Conclusion: Hypothyroidism is common among Jordanian diabetic patients. Obesity among the female gender could be an indicator for detecting hypothyroidism in T2DM patients.

Author Biographies

Amjad Al Shdaifat, The Hashemite University, Zarqa, Jordan

Department of Internal and Family Medicine, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan

Huda Al Hourani, The Hashemite University, Zarqa, Jordan

Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa 13133, Jordan

Manar Atoum, The Hashemite University, Zarqa, Jordan

Manar F Atoum

Department Medical Laboratory Sciences

Faculty Applied Health Sciences

The Hashemite University / Zarqa/ Jordan

P.O. Box 330127, postal code 13133, Jordan

Email: [email protected]

Telephone +962 799733894

Muwafag Al Hyari, Prince Hamza Hospital, Diabetic Center, Amman, Jordan

Center of Diabetes and Endocrinology, Prince Hamza Hospital, Diabetic Center, Amman, Jordan

Joseph A. Abulail, The Hashemite University, Zarqa, Jordan

Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan

Iyad Khalifah Ahmad Aldomi, Prince Hamza Hospital, Diabetic Center, Amman, Jordan

Center of Diabetes and Endocrinology, Prince Hamza Hospital, Diabetic Center, Amman, Jordan

Dina Hani Haddad, Prince Hamza Hospital, Diabetic Center, Amman, Jordan

Center of Diabetes and Endocrinology, Prince Hamza Hospital, Diabetic Center, Amman, Jordan

Ahmad Agil, University of Granada, Granada, Spain

Department of Pharmacology, BioHealth Institute Granada (IBs Granada), Neuroscience Institute (CIBM), School of Medicine, University of Granada, 18016 Granada, Spain.

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Published

21-06-2024

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ORIGINAL CLINICAL RESEARCH

How to Cite

1.
Al Shdaifat A, Al Hourani H, Atoum M, Al Hyari M, A. Abulail J, Khalifah Ahmad Aldomi I, et al. Thyroid dysfunction and associated risk factors among type 2 diabetic patients: a cross-sectional study: Thyroid dysfunction and associated risk factors in type 2 diabetics. Acta Biomed [Internet]. 2024 Jun. 21 [cited 2024 Jul. 25];95(3):e2024054. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/15315