Assessment of anosmia/hyposmia in post-COVID-19 patients: a cross-sectional study in an eastern province of Saudi Arabia

Assessment of anosmia/hyposmia in post-COVID-19 patients: a cross-sectional study in an eastern province of Saudi Arabia

Authors

Keywords:

COVID-19, Olfactory dysfunction, Anosmia, Hyposmia, Saudi Arabia

Abstract

Background and aim It has been shown that olfactory dysfunction is one of Coronavirus disease-2019 (COVID-19)common and puzzling symptoms that may persist weeks after the infection. This study aimed for the objective assessment of persisting olfactory dysfunction in post-COVID-19 patients. It also investigated the factors associated with the development of such symptoms in the Eastern Province of Saudi Arabia. Methods: A cross-sectional study that was conducted in the Department of Physiology, College of Medicine, Imam Abdulrahman bin Faisal University, Khobar, Saudi Arabia. One hundred and forty-seven participants were included in this study, and sixty of them agreed  to participate in the objective testing using the Connecticut Chemosensory Clinical Research Center (CCCRC) olfaction test. Results: There was a significant correlation between the following factors: (1) Persistence of anosmia/hyposmia and the time of onset of anosmia/hyposmia (P=0.015). (2) Persistence of anosmia/hyposmia and the duration of anosmia/hyposmia (P=0.012). (3) Duration of anosmia/hyposmia and the duration of COVID-19 symptoms (P=0.010). Interestingly, there was a significant association between the subjective participants’ claim of anosmia/hyposmia and the score of their objective assessment (P=0.026). Conclusion: The current study demonstrated that post-COVID-19 participants with delayed onset of anosmia/hyposmia and/or longer duration of either anosmia/hyposmia or COVID-19 symptoms were prone to have persistent olfactory dysfunction. Further studies are necessary to uncover the underlying pathophysiology and management of this olfactory dysfunction in COVID-19 patients.

References

Centers for Disease Control and Prevention. Basics of COVID-19 [Internet]. 4 Nov 2021 [cited 4 Oct 2022]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/your-health/about-covid-19/basics-covid-19.html

World Health Organization. COVID-19 weekly epidemiological update, edition 110 [Internet]. 21 Sep 2022. [cited 4 Oct 2022]. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---21-september-2022

Jabali MA, Alsabban AS, Bahakeem LM, et al. Persistent symptoms post-COVID-19: An observational study at King Abdulaziz Medical City, Jeddah, Saudi Arabia. Cureus. 2022;14(4). doi: 10.7759/cureus.24343.

Jernigan DB. Update: public health response to the coronavirus disease 2019 outbreak—United States, February 24, 2020. Morbidity and mortality weekly report. 2020;69(8):216. doi: 10.15585/mmwr.mm6908e1.

Paderno A, Schreiber A, Grammatica A, et al. Smell and taste alterations in COVID‐19: A cross‐sectional analysis of different cohorts. International Forum of Allergy & Rhinology. 2020;10(8):955-962. doi: 10.1002/alr.22610.

D’Ascanio L, Pandolfini M, Cingolani C, et al. Olfactory dysfunction in COVID-19 patients: prevalence and prognosis for recovering sense of smell. Otolaryngology–Head and Neck Surgery. 2021;164(1):82-6. doi:10.1177/0194599820943530.

World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus [Internet]. 6 Oct 2021. [cited 4 Oct 2022]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1

Saltagi AK, Saltagi MZ, Nag AK, et al. Diagnosis of anosmia and hyposmia: A systematic review. Allergy & Rhinology. 2021;12:21526567211026568. doi: 10.1177/21526567211026568.

Lechien JR, Chiesa‐Estomba CM, Beckers E, et al. Prevalence and 6‐month recovery of olfactory dysfunction: A multicentre study of 1363 COVID‐19 patients. Journal of Internal Medicine. 2021;290(2):451-61. doi: 10.1111/joim.13209.

Mariani F, Morello R, Traini DO, et al. Risk factors for persistent anosmia and dysgeusia in children with SARS-CoV-2 infection: a retrospective study. Children (Basel). 2023;10(3):597. doi: 10.3390/children10030597.

Ludwig S, Schell A, Berkemann M, et al. post-COVID-19 impairment of the senses of smell, taste, hearing, and balance. Viruses. 2022;14(5):849. doi: 10.3390/v14050849.

Lechner M, Liu J, Counsell N, et al. High prevalence of persistent smell loss and qualitative smell dysfunction during the coronavirus disease 2019 (COVID-19) pandemic in the United States: urgent need for clinical trials. International Forum of Allergy & Rhinology. 2022;10.1002/alr.23100. doi: 10.1002/alr.23100.

Khodeir MM, Shabana HA, Rasheed Z, et al. COVID-19: post-recovery long-term symptoms among patients in Saudi Arabia. Public Library of Science One. 2021;16(12): e0260259. doi: 10.1371/journal.pone.0260259.

Algahtani SN, Alzarroug AF, Alghamdi HK, Algahtani HK, Alsywina NB, Bin Abdulrahman KA. Investigation on the factors associated with the persistence of anosmia and ageusia in Saudi COVID-19 patients. International Journal of Environmental Research and Public Health. 2022;19(3):1047. doi: 10.3390/ijerph19031047.

AlRadini FA, Alamri F, Aljahany MS, et al. Post-acute COVID-19 condition in Saudi Arabia: A national representative study. Journal of Infection and Public Health. 2022;15(5):526-32. doi: 10.1016/j.jiph.2022.03.013.

Mahmoud N, Radwan N, Alkattan A, et al. post-COVID-19 syndrome: nature of symptoms and associated factors. Journal of Public Health. 2023:1-6. doi: 10.1007/s10389-022-01802-3.

Alkwai HM, Khalifa AM, Ahmed AM, et al. Persistence of COVID-19 symptoms beyond 3 months and the delayed return to the usual state of health in Saudi Arabia: A cross-sectional study. SAGE Open Medicine. 2022; 10:20503121221129918. doi: 10.1177/20503121221129918.

Doty RL. Olfactory dysfunction and its measurement in the clinic. World Journal of Otorhinolaryngology-Head and Neck Surgery. 2015;1(01):28-33. doi: 10.1016/j.wjorl.2015.09.007.

Cain WS, Goodspeed RB, Gent JF, Leonard G. Evaluation of olfactory dysfunction in the Connecticut chemosensory clinical research center. The Laryngoscope. 1988;98(1):83-8. doi: 10.1288/00005537-198801000-00017.

Vaira LA, Deiana G, Fois AG, et al. Objective evaluation of anosmia and ageusia in COVID‐19 patients: single‐center experience on 72 cases. Head & neck. 2020;42(6):1252-8. doi: 10.1002/hed.26204.

Paranhos AC, Dias ÁR, da Silva LC, et al. Sociodemographic characteristics and comorbidities of patients with long COVID and persistent olfactory dysfunction. The Journal of the American Medical Association. 2022;5(9): e2230637-. doi: 10.1001/jamanetworkopen.2022.30637.

Kaya A, Altıparmak S, Yaşar M, Özcan İ, Çelik İ. Objective evaluation of smell and taste senses in COVID-19 patients. Turkish Archives of Otorhinolaryngology. 2022;60(3):128. doi: 10.4274/tao.2022.2022-6-1.

Alabsi RA, Sandeepa NC, Misfer RT, Alraqdi MM, Hamdi MI. Correlation between post-COVID-19, chemosensitive function, blood group, and oral health-related quality of life. International Journal of Dentistry. 2022;2022. doi: 10.1155/2022/8715777.

Centers for Disease Control and Prevention. Epi InfoTM for mobile devices [Internet]. 21 Feb 2023. [cited 7 Oct 2022]. Available from: https://www.cdc.gov/epiinfo/index.html

Telmesani LM, Althomaly DH, Buohliqah LA, et al. Clinical otorhinolaryngological presentation of COVID-19 patients in Saudi Arabia: A multicenter study. Saudi Medical Journal. 2022;43(3):266-274. doi: 10.15537/smj.2022.43.3.20210501.

Wong DK, Gendeh HS, Thong HK, et al. A review of smell and taste dysfunction in COVID-19 patients. Medical Journal of Malaysia. 2020;75(5):574-81. PMID: 32918429.

Augustin M, Schommers P, Stecher M, et al. Post-COVID syndrome in non-hospitalized patients with COVID-19: A longitudinal prospective cohort study. The Lancet Regional Health - Europe. 2021;6:100122. doi: 10.1016/j.lanepe.2021.100122.

Lechien JR, Cabaraux P, Chiesa‐Estomba CM, et al. Objective olfactory evaluation of self‐reported loss of smell in a case series of 86 COVID‐19 patients. Head & Neck. 2020;42(7):1583-90. doi: 10.1002/hed.26279.

Gözen ED, Aliyeva C, Tevetoğlu F, et al. Evaluation of olfactory function with objective tests in COVID-19-positive patients: A cross-sectional study. Ear, Nose & Throat Journal. 2021;100(2_suppl):169S-73S. doi: 10.1177/0145561320975510.

Pinto JM. Olfaction. Proceedings of the American Thoracic Society. 2011;8(1):46-52. doi: 10.1513/pats.201005-035RN.

Branigan B, Tadi P. Physiology, Olfactory. StatPearls. 2023. PMID: 31194396

Butowt R, von Bartheld CS. Anosmia in COVID-19: underlying mechanisms and assessment of an olfactory route to brain infection. The Neuroscientist. 2021;27(6):582-603. doi: 10.1177/1073858420956905.

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Published

05-12-2023

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Section

ORIGINAL CLINICAL RESEARCH

How to Cite

1.
Mohamed R, Alsuhibani R, Almasaoud H, Alsubhi S, Alabdulazeem L, Alzahrani N, et al. Assessment of anosmia/hyposmia in post-COVID-19 patients: a cross-sectional study in an eastern province of Saudi Arabia. Acta Biomed [Internet]. 2023 Dec. 5 [cited 2024 Jul. 17];94(6):e2023259. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/15130