Breast metastasis in a young pregnant woman affected by metastatic melanoma

Breast metastasis in a young pregnant woman affected by metastatic melanoma

Authors

  • Martina Pia Pagliara
  • Annalisa Gorgoglione
  • Vincenza Talamo
  • Maria Teresa Paparella
  • Nicola Palladino
  • Marina Castelvetere
  • Ettore Angelo Serricchio
  • Giuseppe Guglielmi

Keywords:

breast metastasis, malignant melanoma, pregnancy

Abstract

Metastasis to the breast from extramammary tumors are rare, and the most common cancer that metastasizes to this site is malignant melanoma (MM). Unfortunately, metastases from malignant melanoma reveal a widespread of the disease and a high likeliness of poor diagnosis. In this study, a case of left breast metastasis of MM in a young pregnant woman, with a fast progression of the mammary and systemic course of pathology and unfortunately poor prognosis is presented. Despite the role of pregnancy in MM has yet to be unraveled, our study encourages the theory that immunosuppression and hormonal changes due to pregnancy may aggravate melanoma prognosis.

References

Ravled L, Robinson WA, et al. Metastatic melanoma in the breast: a report of 27 cases J Surg Oncol.2006;94(2):101-4.

Kock A, Ritcher-Marot A, Wissler MP, et al. Mammary metastasis of extramammary cancers: current knowledge and diagnostic difficulties. Gynecol Obstet Fertil.2013;41:653-9.

Saad Abdalla Al-Zawi A, Idaewor P, Elamass M, et al. Primary lung cancer with metastasis to the ipsilateral breast-a case report.International Journal of Research in Medical Science 2017;6(1);334-339.

Zhou Shuling;Yu Baohua,Chen Yufan;Xu Xiaoli,Shui Ruohong,Bi Rui, et al.Metastases to the breast from non-mammary malignancies;a clinicopathologic study of 28 cases Chin J Pathol.2014;43(04):231-235.

Recine Ma,Deavers MT,Middleton LP,Silva EG,Malpica A. Serous carcinoma of the ovary and peritoneum with metastases to the breast and axillary limph nodes:A potential pitfall.Am J Surg Pathol.2014;43(04):231-235

Delair DF,Corben AD,Catalano JO,Vallejo CE;,Brogi E,Tan LK.Non-mammy metastases to the breast and axilla:a study of 85 cases.Mod Pathol.2013,26(3);343-9.

A Sandru, S Voinea, E Painaitescu and A Blidaru;survival rates of patients with metastatic malignant melanoma, J Med life.2014;7(4):572-576

Moschetta M,et al.Metastatic breast disease from cutaneous malignant melanoma.Int. J Surg Rep.2014;5(1):34-6.

Jue KF, et al,Unusal sonographic appearance of melanoma metastases to the breast.J Ultrasound Med.2006;25:663-6

Bae J,Choi YY,Kim DS,Lee JH,et al.Metastatic melanoma of unknown primary show better prognosis than those of know primary: a systematic review and meta-analysis of observational studies J Am Acad Dermatol.2015;72:59-70

De Waal AC,Aben KK van Rossum MM, Kiemeney LA.Melanoma of unknown primary origin: a population based study in Netherlands.Eur J Cancer.2013;49:676-83.

Majeski J.Bilateral breast masses as initial presentation of widely metastatic melanoma. J Surg Oncol.1999;72(3):175-7.-

Al Samaraee A,Khout H,Barakat T,Fasih T.Breast metastasis from a mekanoma.Ochsner J.2012;12(2):149-51.

Cangiarella J,Symmans WF,Cohen JM,Goldenberg A, Shapiro RL,Waisman J.Malignant melanoma metastatic to the breast:a report of seven cases diagnosed by fine-needle aspiration cytology.Cancer.1998;84(3):160-162.

Teodorescu EC.Sonography snd mammography of primary malignant breast melanoma.Med Ultr.2008;10(1)55-8.

Lee AH.The histological diagnosis of metastases to the breast from extramammary malignancies:J Clin Pathol.2007;60(12):1333-41.

Schmidt AN,Nanney LB,Boyd AS, et al.Oestrogen receptor-beta expression in melanocytic lesions.Exp Dermatol.2006;15:971-980.

Sober AJ,Lew RA,Koh HK,Barnhill RL.Epidemiology of cutaneous melanoma :an update .Dermatol Clin 1991;9:617-29.

Neifield JP,Lippman MC.Steroid hormone receptors and melanoma.J Invest Dermatol 1980;74:379-81.

Grill HJ,Benes P,Manz B,Schramm P,Morsches B,Korting GW,et al.Steroid hormone receptor analysis in human melanoma and non-malignant human skin.Br J Dermatol 1982;107(Suppl 23):64-5

Lopez RE,Bhakoo H,Paolini NS, Rosen G, Holyoke ED,Goldrosen MH.Effect of estrogen on the growth of B-16 melanoma.Surg Forum 1978;29:153-4.

Gupta A,Driscoll MS.Do hormones influence melanoma?Facts and controversies.Clin Dermatol.2010;28:287-292.

Leber A,Teles A,Zenclussen AC.Regulatory T-cells and their role in pregnancy. Am J Reprod Immunol.2010;63:445-459.

Holtan SG,Creedon DJ,Haluska P,Markovic SN,Cancer and pregnancy:parallels in growth,invasion and immune modulation and implication for cancer therapeutic agents, Mayo Clin Proc.2009;84:985-1000.

Nevala WK,Vachon CM,Leontovich,et al.Evidence of systemic Th2-driven chronic inflammation in patients with metastatic melanoma.Clin Canc Res.2009;15:1931-1939.

Lacal PM, Failla CM,Pagani E,Odorisio T,Schietroma C,Falcinell S,et al.Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor.J invest Dermatol 2000;115:1000-7.

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Published

24-07-2023

Issue

Section

Case Reports: Oncology and Hematology

How to Cite

1.
Pagliara MP, Gorgoglione A, Talamo V, et al. Breast metastasis in a young pregnant woman affected by metastatic melanoma. Acta Biomed. 2023;94(S1):e2023200. doi:10.23750/abm.v94iS1.14508