Unspecific congenital toxoplasmosis in a two-month-old baby

Unspecific congenital toxoplasmosis in a two-month-old baby

Authors

  • Sri Wahdini Dept of Parasitology, Faculty of Medicine, Universitas Indonesia. Jakarta, Indonesia
  • Ika Puspa Sari
  • Hanifah Oswari
  • Agnes Kurniawan

Keywords:

congenital toxoplasmosis, baby, unspecific toxoplasmosis

Abstract

A two-month-old baby boy diagnosed with unspecific congenital toxoplasmosis was referred by a pediatrician to the Clinical Parasitology referral center at the Faculty of Medicine, Universitas Indonesia. Baby was post-hospitalized in the NICU and required ventilation support for one month. Furthermore, there was history of from various medical conditions, such as intracranial bleeding, convulsion, hypertrophic cardiomyopathy, retinopathy, and renal failure. After two month, there was no significant weight gain, anti-Toxoplasma IgM showed positive results, and anti-Toxoplasma IgM and IgG of the mother were also positive. Baby and mother were successfully treated with pyrimethamine, cotrimoxazole, and folinic acid for one month. At 2 years, there signs of normal motoric, eye, and hearing development with underdeveloped kidneys. Therefore, pre-pregnancy counseling and education aimed at preventing toxoplasmosis during pregnancy should be increased and conducted routinely by health workers or trained cadres to reduce the risk of fetal defects.

References

McAuley JB. Congenital Toxoplasmosis. J Pediatric Infect Dis Soc. 2014 Sep;3 Suppl 1(Suppl 1):S30-5. doi: 10.1093/jpids/piu077.

Peyron F, L'ollivier C, Mandelbrot L, et al. Maternal and congenital toxoplasmosis: diagnosis and treatment recommendations of a french multidisciplinary working group. Pathogens. 2019 Feb 18;8(1):24. doi: 10.3390/pathogens8010024.

Polanunu NFA, Wahyuni S, Hamid F. Seroprevalence and associated risk factors of Toxoplasma gondii infection among pregnant mother in Makassar, Indonesia. PLoS One. 2021 Jun 4;16(6):e0245572. doi: 10.1371/journal.pone.0245572..

Petersen E, Meroni V, Vasconcelos-Santos DV, Mandelbrot L, Peyron F. Congenital toxoplasmosis: should we still care about screening? Food Waterborne Parasitol. 2022 May 11;27:e00162. doi: 10.1016/j.fawpar.2022.e00162.

Teimouri A, Mohtasebi S, Kazemirad E, Keshavarz H, Pritt BS. Role of Toxoplasma gondii IgG avidity testing in discriminating between acute and chronic toxoplasmosis in pregnancy. 2020 Aug 24;58(9):e00505-20. doi: 10.1128/JCM.00505-20.

Wallon M, Peyron F, Cornu C, et al. Congenital toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years. Clin Infect Dis. 2013 May;56(9):1223-31. doi: 10.1093/cid/cit032.

Rehman F, Shah M, Ali A, Rapisarda AMC, Cianci A. Seroprevalence and risk factors of Toxoplasma gondii infection in women with recurrent fetal loss from the province of Khyber Pakhtunkhwa, Pakistan. J Neonatal Perinatal Med. 2021;14(1):115-121. doi: 10.3233/NPM-190323.

Almogren A. Antenatal screening for Toxoplasma gondii infection at a tertiary care hospital in Riyadh, Saudi Arabia. Ann Saudi Med. 011 Nov-Dec;31(6):569-72. doi: 10.4103/0256-4947.87090.

Prusa AR, Kasper DC, Sawers L, Walter E, Hayde M, Stillwaggon E. Congenital toxoplasmosis in Austria: prenatal screening for prevention is cost-saving. PLoS Negl Trop Dis. 2017 Jul 10;11(7):e0005648. doi: 10.1371/journal.pntd.0005648.

Stillwaggon E, Carrier CS, Sautter M, McLeod R. Maternal serologic screening to prevent congenital toxoplasmosis: a decision-analytic economic model. PLoS Negl Trop Dis. 2011 Sep;5(9):e1333. doi: 10.1371/journal.pntd.0001333.

Downloads

Published

24-07-2023

Issue

Section

Case Reports: Pediatrics and Neonatology

How to Cite

1.
Wahdini S, Sari IP, Oswari H, Kurniawan A. Unspecific congenital toxoplasmosis in a two-month-old baby. Acta Biomed. 2023;94(S1):e2023144. doi:10.23750/abm.v94iS1.14308