Study of the hepcidin level in pregnant women with and without anemia

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Raisa Aringazina
Aigul Mussina
Nurgul Zholdassova
Nazgul Seitmaganbetova
Gulnara Gubasheva


anemia, pregnancy, hepcidin


Background and aim: Currently, a wide range of laboratory markers characterizing iron metabolism is available to clinicians. However, they are mainly limited by determining the hemoglobin content, iron concentration and erythrocyte morphology, which makes it impossible to differentiate iron deficiency anemia from other hypochromic anemia forms. The study aimed to evaluate the diagnostic value of hepcidin as a ferrokinetics marker under the development of anemia during pregnancy. Methods: The study included 60 pregnant women (average age 26.0±0.74 years). They were divided into two groups. The participants of the Main group had hypochromic microcytic anemia with the reference values of the red blood cells 4.15 million/µL and the hemoglobin level 105 g/L. The reference values of these marks in the Control group were 4.54 million/µL and 124.50 g/L respectively. Results: Low levels of Fe, ferritin, and hepcidin were detected in pregnant women with anemia. The serum hepcidin concentration of women with anemia was 0.55 ng/mL. The anemia-diagnosed group had a reduced ferritin level by 32% (4.5 ng/mL). This point for the Control group was 14.0 ng/mL. A positive moderate relationship was indicated for hepcidin and Fe (r=0.39; P=0.05). At the same time, a negative moderate relationship (r=-0.56; P=0.05) was found between hepcidin and ferritin. Conclusions: Data from pregnant women with anemia showed hypochromic microcytic anemia with a serum ferritin level of 4.5 ng/mL and hepcidin level of 0.55ng/mL. The present research furtherly supports the valid role of hepcidin in the diagnosis of iron deficiency anemia in pregnant women. (


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1. WHO. Global prevalence of anemia in 2011. Geneva, Switzerland: Health organization; 2011. Available at (Accessed at 24.11.2022).
2. Haidar JA, Pobocik RS. Iron deficiency anemia is not a rare problem among women of reproductive ages in Ethiopia: a community-based cross sectional study. BMC Hematology 2009;9:1-8.
3. Agrawal S, Fledderjohann J, Vellakkal S, Stuckler D. Adequately diversified dietary intake and iron and folic acid supplementation during pregnancy is associated with reduced occurrence of symptoms suggestive of pre-eclampsia or eclampsia in Indian women. PLoS One 2015;10:e011912.
4. Hercberg S, Galan P, Preziosi P, Aissa M. Consequences of iron deficiency in pregnant women: current issues. Clin Drug Investing 2000;19:1-7.
5. Breymann C. Assessment and differential diagnosis of iron-deficiency anaemia during pregnancy. Clin Drug Investig 2000;19:21-7.
6. Cappellini MD, Motta I. Anemia in clinical practice—definition and classification: does hemoglobin change with aging? Semin Hematol 2015;52:261-9.
7. Guyton A, Hall J. Red blood cells, anemia and polycythemia. Textbook of medical physiology. 11h edition. Chapter 32. Philadelphia: Elsevier; 2006.
8. Tarasova NE, Teplyakovа ED. [Ferrokinetics and the mechanisms of its regulation in human organism]. Zhurnal fundamental’noy meditsiny i biologii 2012;1:10-6. Russian.
9. Aringazina R, Zharmakhanova G, Kurmanalina G, Bekkuzhin A, Kurmanalin B. Diagnostic relevance of ferrokinetic laboratory markers in anemic pregnant women. Gynecol Obstetric Investigation 2020;85:420-7.
10. Peltek I. [Dynamics of the iron levels in pregnant women]. Hematol Transfusiol East Eur 2015;1:100-4. Russian.
11. World Health Organization. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva. Licence; 2020.
12. Bobrov SA, Repina MA, Klitsenko OA. [Serum ferritin as a prognostic factor for the development of iron deficiency anemia in pregnant women]. J Obstetrics Women's Dis 2011;60:49-55. Russian.
13. Zhang X, Gou YJ, Zhang Y, et al. Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice. Cell Death Disc 2020;6:113.
14. Maakaron JE, Taher AT, Conrad ME. Anemia Workup. Medscape; 2021. Available at (Accessed at 14.08.2022).
15. Medvid VI, Zhuk SI, Kondratyuk KO. [Iron, iron deficiency, anemia: significance for women's health and not only…].; 2020:10-1. Ukrainian. Available at: (Accessed at 15.08.2022).
16. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood 2008;112:4292-7.
17. Zhang H, Li Y, Pu M, Xu P, Liang G, Yu D. Oryza sativa possitive regulation of iron deficiency responce 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis. Plant Cell Environm 2020;43:261-274.
18. Provan D. (Ed.). ABC of clinical haematology. 4th Ed. John Wiley & Sons; 2009. 114 p.
19. Mehta A, Hoffbrand V. Haematology at a Glance. 4rd Ed. John Wiley & Sons; 2013. 137 p.
20. Huch R, Breymann C. Anaemia in pregnancy and the puerperium. 2nd Ed. Bremen: Uni-Med; 2005. 96 p.
21. Pitkin J, Peattie A, Magowan BA. Obstetrics and Gynecology. 1st. Ed. London: Churchill Livingstone; 2003. 172 p.
22. Chernishova E. [Assessment of iron status in the body: what does the practitioner need to know?]; 2020. Russian. Available at: (Accessed at 15.08.2022).
23. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006;26:323-42.
24. Pagani A, Nai A, Silvestri L, Camaschella C. Hepcidin and anemia: a tight relationship. Frontiers Physiol 2019;10:1294.

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