A short update on new approaches to celiac disease

A short update on new approaches to celiac disease


  • Btihaj Al Ibrahmi Department of Biology, faculty of Science, University Ibn Tofail, kenitra , Morocco
  • Abdellatif Bour department of Biology, faculty of Science, University Ibn Tofail, kenitra , Morocco


Celiac Disease; Gluten-free diet; Elafin ; Endoproteolytic enzyme; Pseudocereals.


Celiac disease is an autoimmune enteropathy of the small intestine, related to gluten intolerance occurring in genetically predisposed patients. Currently, the only available treatment is a lifelong gluten-free diet. However, the total avoidance of gluten is difficult and poses a challenge to patients, nutritionists and treating physicians. For this reason, scientists have developed in recent years new therapeutic approaches complementary to dietary treatment, such as modification of gluten to make gliadin non-toxic, reduction of the inflammatory response with elafin and Lactococcus Lactis, degradation of gluten by endoproteolytic enzymes, and correction of nutritional deficiencies by adding pseudo-cereals to the diet of celiac patients. This literature review focuses on the different treatment strategies for celiac disease previously studied and summarizes the latest advances in this field.


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How to Cite

Al Ibrahmi B, Bour A. A short update on new approaches to celiac disease. Acta Biomed [Internet]. 2022 Dec. 16 [cited 2024 Jul. 14];93(6):e2022322. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/13673