Dependence of the dynamics of changes in the quality of life of patients with bacterial vaginosis on local levels of TNF-α and IL-1β

Dmytro Grebeniuk; Oleksandr Nazarchuk; Nataliia  Dzis; Illia Taran; Elina  Slyvka; Vahif  Abdullaiev; Vitalii  Bobyr; Oksana Mashevska

doi:10.23750/abm.v93i4.12461

Dependence of the dynamics of changes in the quality of life of patients with bacterial vaginosis on local levels of TNF-α and IL-1β

Authors

Dmytro Grebeniuk National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0002-6760-7494
Oleksandr Nazarchuk National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0001-7581-0938
Nataliia Dzis National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0001-8396-171X
Illia Taran National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0003-0488-6083
Elina Slyvka National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0001-6653-0221
Vahif Abdullaiev National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0002-6233-1898
Vitalii Bobyr Bohomolets National Medical University https://orcid.org/0000-0002-8310-8011
Oksana Mashevska National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0003-4396-5163

DOI: https://doi.org/10.23750/abm.v93i4.12461

Keywords:

bacterial vaginosis, inflammatory mediators, TNF-α, IL-1β, quality of life

Abstract

Background and aim: Bacterial vaginosis is among serious health problem for women of reproductive age which influences on their local changes in inflammatory mediators and quality of life. The aim was to assess the dependence of the dynamics of changes in the quality of life of patients with bacterial vaginosis on local levels of TNF-α and IL-1β.

Methods: In the prospective study 37 women aged 19-40 years with bacterial vaginosis were treated according to the Centers for Disease Control and Prevention. Patients received vaginal suppositories of clindamycin phosphate (100 mg) once daily for 3 days before bedtime. TNF-α, IL-1β levels in vaginal secretions by means of ELISA test), as well as the quality of life according to the RAND 36-Item Health Survey 1.0 were studied as in control group (once - to determine the reference values) and in the dynamics (the 1st day – before treatment, on the 7th day – after treatment) in the main group.

Results: After the treatment microscopy of smears-imprints of vaginal secretions showed the complete absence of pathological microflora. The treatment was well tolerated by all patients. In the result there was proved the role of bacterial vaginosis in a violation of the quality of life of patients mainly due to the mental component of health, even after clinical and laboratory recovery.

Conclusions: There was proved the relation of vaginal TNF-α and IL-1β with physical and mental health in patients with bacterial vaginosis which can have a prognostic significance of the disease.

Author Biographies

Dmytro Grebeniuk, National Pirogov Memorial Medical University, Vinnytsya

PhD, As. Prof. of the Department of Endoscopic and Cardiovascular Surgery of National Pirogov Memorial Medical University, Vinnytsya

Oleksandr Nazarchuk, National Pirogov Memorial Medical University, Vinnytsya

DM, As. Prof. of the Department of Microbiology of National Pirogov Memorial Medical University, Vinnytsya

Nataliia Dzis , National Pirogov Memorial Medical University, Vinnytsya

DM, Prof. of the Department of Obstetrics and Gynecology №2 of National Pirogov Memorial Medical University, Vinnytsya

Illia Taran, National Pirogov Memorial Medical University, Vinnytsya

PhD, As. Prof. of the Department of Pharmacology of National Pirogov Memorial Medical University, Vinnytsya

Elina Slyvka , National Pirogov Memorial Medical University, Vinnytsya

PhD, Assistant of Department of Obstetrics and Gynecology №2 of National Pirogov Memorial Medical University, Vinnytsya

Vahif Abdullaiev , National Pirogov Memorial Medical University, Vinnytsya

Assistant of Department of Obstetrics and Gynecology №2 of National Pirogov Memorial Medical University, Vinnytsya

Vitalii Bobyr , Bohomolets National Medical University

DM, As. Prof. of the Department of Microbiology, Virology and Immunology of Bohomolets National Medical University

Oksana Mashevska , National Pirogov Memorial Medical University, Vinnytsya

PhD, As. of the Department of Oncology, X-ray diagnostics and Therapy of National Pirogov Memorial Medical University, Vinnytsya

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