Main Article Content
bacterial vaginosis, inflammatory mediators, TNF-α, IL-1β, quality of life
Background and aim: Bacterial vaginosis is among serious health problem for women of reproductive age which influences on their local changes in inflammatory mediators and quality of life. The aim was to assess the dependence of the dynamics of changes in the quality of life of patients with bacterial vaginosis on local levels of TNF-α and IL-1β.
Methods: In the prospective study 37 women aged 19-40 years with bacterial vaginosis were treated according to the Centers for Disease Control and Prevention. Patients received vaginal suppositories of clindamycin phosphate (100 mg) once daily for 3 days before bedtime. TNF-α, IL-1β levels in vaginal secretions by means of ELISA test), as well as the quality of life according to the RAND 36-Item Health Survey 1.0 were studied as in control group (once - to determine the reference values) and in the dynamics (the 1st day – before treatment, on the 7th day – after treatment) in the main group.
Results: After the treatment microscopy of smears-imprints of vaginal secretions showed the complete absence of pathological microflora. The treatment was well tolerated by all patients. In the result there was proved the role of bacterial vaginosis in a violation of the quality of life of patients mainly due to the mental component of health, even after clinical and laboratory recovery.
Conclusions: There was proved the relation of vaginal TNF-α and IL-1β with physical and mental health in patients with bacterial vaginosis which can have a prognostic significance of the disease.
2. Bautista CT, Wurapa E, Sateren WB, Morris S, Hollingsworth B, Sanchez JL. Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Mil Med Res. 2016 Feb 13;3:4. doi: 10.1186/s40779-016-0074-5. PMID: 26877884; PMCID: PMC4752809.
3. Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol. 2013 Dec;209(6):505-23. doi: 10.1016/j.ajog.2013.05.006. Epub 2013 May 6. PMID: 23659989.
4. Ceccarani C, Foschi C, Parolin C et al. Diversity of vaginal microbiome and metabolome during genital infections. Sci Rep. 2019 Oct 1;9(1):14095. doi: 10.1038/s41598-019-50410-x. PMID: 31575935; PMCID: PMC6773718.
5. Redelinghuys MJ, Geldenhuys J, Jung H, Kock MM. Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities. Front Cell Infect Microbiol. 2020 Aug 11;10:354. doi: 10.3389/fcimb.2020.00354. PMID: 32850469; PMCID: PMC7431474.
6. Tomás MS, Claudia Otero M, Ocaña V, Elena Nader-Macías M. Production of antimicrobial substances by lactic acid bacteria I: determination of hydrogen peroxide. Methods Mol Biol. 2004;268:337-46. doi: 10.1385/1-59259-766-1:337. PMID: 15156044.
7. Vazquez F, Fernández-Blázquez A, García B. Vaginosis. Vaginal microbiota. Enferm Infecc Microbiol Clin (Engl Ed). 2019 Nov;37(9):592-601. English, Spanish. doi: 10.1016/j.eimc.2018.11.009. Epub 2018 Dec 26. PMID: 30594321.
8. Coudray MS, Madhivanan P. Bacterial vaginosis-A brief synopsis of the literature. Eur J Obstet Gynecol Reprod Biol. 2020 Feb;245:143-148. doi: 10.1016/j.ejogrb.2019.12.035. Epub 2019 Dec 24. PMID: 31901667; PMCID: PMC6989391.
9. Eastment MC, McClelland RS. Vaginal microbiota and susceptibility to HIV. AIDS. 2018 Mar 27;32(6):687-698. doi: 10.1097/QAD.0000000000001768. PMID: 29424773; PMCID: PMC5957511.
10. Mastromarino P, Hemalatha R, Barbonetti A et al. Biological control of vaginosis to improve reproductive health. Indian J Med Res. 2014 Nov;140 Suppl(Suppl 1):S91-7. PMID: 25673551; PMCID: PMC4345761.
11. Reda S, Gonçalves FA, Mazepa MM, De Carvalho NS. Women infected with HIV and the impact of associated sexually transmitted infections. Int J Gynaecol Obstet. 2018 Aug;142(2):143-147. doi: 10.1002/ijgo.12507. Epub 2018 May 2. PMID: 29656416.
12. Reiter S, Kellogg Spadt S. Bacterial vaginosis: a primer for clinicians. Postgrad Med. 2019 Jan;131(1):8-18. doi: 10.1080/00325481.2019.1546534. Epub 2018 Nov 30. PMID: 30424704.
13. Kielian T, Bearden ED, Baldwin AC, Esen N. IL-1 and TNF-alpha play a pivotal role in the host immune response in a mouse model of Staphylococcus aureus-induced experimental brain abscess. J Neuropathol Exp Neurol. 2004 Apr;63(4):381-96. doi: 10.1093/jnen/63.4.381. PMID: 15099027.
14. Hedges SR, Barrientes F, Desmond RA, Schwebke JR. Local and systemic cytokine levels in relation to changes in vaginal flora. J Infect Dis. 2006 Feb 15;193(4):556-62. doi: 10.1086/499824. Epub 2006 Jan 17. PMID: 16425135.
15. Sexually Transmitted Diseases: Summary of 2015 CDC Treatment Guidelines. J Miss State Med Assoc. 2015 Dec;56(12):372-5. PMID: 26975162.
16. Imseis HM, Greig PC, Livengood CH 3rd, Shunior E, Durda P, Erikson M. Characterization of the inflammatory cytokines in the vagina during pregnancy and labor and with bacterial vaginosis. J Soc Gynecol Investig. 1997 Mar-Apr;4(2):90-4. PMID: 9101468.
17. Sturm-Ramirez K, Gaye-Diallo A, Eisen G, Mboup S, Kanki PJ. High levels of tumor necrosis factor-alpha and interleukin-1beta in bacterial vaginosis may increase susceptibility to human immunodeficiency virus. J Infect Dis. 2000 Aug;182(2):467-73. doi: 10.1086/315713. Epub 2000 Jul 18. PMID: 10915077.