Component resolved diagnosis and risk assessment in food allergy: Molecular diagnosis in food allergy

Component resolved diagnosis and risk assessment in food allergy

Molecular diagnosis in food allergy


  • Alberto Martelli University of Pavia, Pavia, Italy
  • Mauro Calvani UOC di Pediatria. Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy
  • Thomas Foiadelli Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • Mariangela Tosca Allergy Centre, IRCCS G. Gaslini Pediatric Hospital, Genova, Italy
  • Giuseppe Pingitore Pediatrician and Allergist, Rome, Italy
  • Amelia Licari Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • Alessia Marseglia Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • Giorgio Ciprandi Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy
  • Carlo Caffarelli Pediatric Clinic, Department of Medicine and Surgery, Unversity of Parma, Parma, Italy


Component resolved diagnosis, IgE, food allergy, primary care, children


 Allergy testing should only be performed in the context of the clinical history as history provides the cornerstone of diagnosis. In food allergy, some allergy tests often give rise to false positive results and thus can lead to unnecessary avoidance or delay on foods introduction. The use of Component Resolved Diagnosis in combination with conventional sensitization testing improves analytical and diagnostic performance and can lead to the reduction of diagnostic oral food challenges. Component Resolved Diagnosis can be helpful in identifying some risks for the allergic child. Molecular diagnosis can help also in predicting the development of the allergy march, in severe reactions (lipid transfer protein, seed storage proteins, etc.) in food allergy and for potential clinical cross-reactivity.


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How to Cite

Martelli A, Calvani M, Foiadelli T, Tosca M, Pingitore G, Licari A, et al. Component resolved diagnosis and risk assessment in food allergy: Molecular diagnosis in food allergy. Acta Biomed [Internet]. 2021 Nov. 29 [cited 2024 Jul. 13];92(S7):e2021528. Available from: