Biologic drugs in chronic spontaneous urticaria

Biologic drugs in chronic spontaneous urticaria


  • Amelia Licari 1Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  • Sara Manti 1UOC Broncopneumologia Pediatrica e Fibrosi Cistica, AOUP “Vittorio-Emanuele”, San Marco Hospital, Università di Catania, Catania, Italy
  • Salvatore Leonardi 3Department of Clinical and Experimental Medicine, Pediatric Respiratory Unit, San Marco Hospital, University of Catania, Catania, Italy
  • Domenico Minasi Pediatric Unit Great Metropolitan Hospital Reggio Calabria, Reggio Calabria, Italy
  • Carlo Caffarelli Pediatric Clinic, Department of Medicine and Surgery, Unversity of Parma, Parma, Italy
  • Fabio Cardinale Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy
  • Michele Miraglia Del Giudice Department of Woman, Child and Specialized Surgery, University of Campania "Luigi Vanvitelli
  • Mauro Calvani UOC di Pediatria. Azienda ospedaliera S. Camillo Forlanini, Rome, Italy
  • Giorgio Ciprandi Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy
  • Gian Luigi Marseglia Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy


Biologics, children, adult, chronic spontaneous urticaria, clinical trials


Chronic spontaneous urticaria (CSU) is a condition defined by the presence of recurrent urticaria, angioedema, or both, which persist for more than six weeks in duration and occurs in the absence of an identifiable trigger. Both children and adults can develop CSU, although it is more common in adults and in women than in men, with a peak occurrence in the third to fifth decades of life. It imposes a significant burden on patients, families and healthcare systems. The goal of therapy in patients with CSU is to achieve a level of symptom control and improvement in quality of life that is acceptable to the patient, while minimizing therapy-related side effects. The recent introduction of biologic drugs has changed the management of the disease. This work aims to provide a narrative review of the current state of biological therapy and the promising drugs under development for CSU.


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How to Cite

Licari A, Manti S, Leonardi S, Minasi D, Caffarelli C, Cardinale F, et al. Biologic drugs in chronic spontaneous urticaria. Acta Biomed [Internet]. 2021 Nov. 29 [cited 2024 Jul. 15];92(S7):e2021527. Available from: