Biomedicine and traditional Chinese medicine: a fruitful scientific and cultural interaction

Biomedicine and traditional Chinese medicine: a fruitful scientific and cultural interaction


  • Lorenzo Mortara Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, Varese (Italy)
  • Grace Coco Biotechnology and Life Sciences, University of Insubria, Varese (Italy)
  • Cristina Pozzi Department of Human Sciences for Education 'Riccardo Massa', University of Milan-Bicocca, Milan (Italy)


Traditional Chinese medicine, biomedicine, acupuncture, western health system


Over the years, the approach of traditional Chinese medicine has changed, as has the concept of the health status. Particularly in this article we will focus on the importance of some techniques that we can define millennial, as acupuncture. We will highlight the relationship between a millenary system and the principles of modernity, emphasizing the relevance of a technique that appears to be in line with the latest scientific research and numerous studies of effectiveness, proposing therapeutic integration as a usable way. We will see how acupuncture has an anti-inflammatory effect, and has a beneficial role in subjects suffering from allergic or autoimmune diseases, including an antihistamine action and downregulation of proinflammatory cytokines (e.g. IL-1β, IL-6 and TNF-α). In addition, acupuncture could also act as an immunomodulatory agent, involving the neuroimmune network, T helper and natural killer cells. Traditional Chinese medicine, acupuncture in particular, is widely used within Western health systems and there are many studies done regarding its efficacy in the clinical field. In addition to scientific validation, however, a comparison on a cultural level is also necessary. To build a constructive dialogue, indeed, it is necessary to deconstruct the preconceptions and prejudices concerning both biomedicine and traditional Chinese medicine. In fact, only through deconstruction we can understand that biomedicine and traditional Chinese medicine are both culturally connoted knowledge. In this article it will first be underlined how clinical observations can be better understood if we pay attention to analyzing the cultural context of the medical systems that here interact with each other. (


(1) Cracoli F, Guastella L, Gozzo A. Agopuntura. Uno sguardo globale. L'uso modernissimo di una tecnica millenaria. Mind edizioni, viale Gran Sasso 20, 20131 Milano, 2000.

(2) Xiaoming L, Gori G, Genitori V. Medicina cinese e biocibernetica. Passato presente e futuro. Bologna: Compositori, via Stalingrado 97/2 40128. 2002.

(3) Di Stanislao C. Libro bianco sull'agopuntura e le altre metodiche terapeutiche della tradizione estremo-orientale. Casa Editrice SIA-CEA, via Romagna 5 20089, Milano. 2000.

(4) Hergert H. Costitutional medicine. Ed. Pascoe. Milano. 1999.

(5) Dei F. Medicine non convenzionali: una prospettiva antropologica, in D. Cozzi (a cura di), Le parole dell’antropologia medica. Piccolo dizionario, Perugia, Morlacchi Editore, Piazza Morlacchi 7/9 06123. 2012, pp. 157-180.

(6) Colombo E, Rebughini P. La medicina contesa. Cure non convenzionali e pluralismo medico. Roma: Carocci editore, Viale di Villa Massimo, 47 00161. 2006.

(7) Kleinman A. Alcuni concetti e un modello per la comparazione dei sistemi medici intesi come sistemi culturali, in I. Quaranta (a cura di), Antropologia medica. I testi fondamentali, Milano, Raffaello Cortina editore, Via G.Rossini 4 20122. 2006, pp. 5-26.

(8) Pizza G. Antropologia medica. Saperi, pratiche e politiche del corpo. Roma: Carrocci Editore. 2005.

(9) Dei F. Antropologia culturale, Bologna, Il Mulino, Strada Maggiore 37 40125. 2012, pp. 147-166.

(19) Scheid V. Chinese Medicine in Contemporary China: Plurality and Synthesis, Durham and London, Duke University Press, 2002.

(11) Wong EY et al. East meets West: current issues relevant to integrating Chinese medicine, Chinese Medicine Journal, vol. VII, September 2012.

(12) Hsu E. The history of Chinese medicine in the people's republic of china and its globalization. 2008. East Asia Science, technology and society: an international journal.

(13) Hobsbawm EJ, Ranger T. 1987. L'invenzione della tradizione.

(14) Unschuld P. Cos'è la medicina? Approcci occidentali e orientali alla cura. Nuova Ipsa editore, Via dei Leoni 71 90146. Palermo. 2015.

(15) McDonald JL, Cripps AW, Smith PK, Smith CA, Xue CC, Golianu B. The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis: a narrative review and proposed model. Evid Based Complement Alternat Med. 2013;2013:591796.

(16) Li A, Zhang RX, Wang Y et al. Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation. BMC Complementary and Alternative Medicine, vol. 7, article 27, 2007.

(17) Kim HW, Uh DK, Yoon SY et al. Low-frequency electroacupuncture suppresses carrageenan-induced paw inflammation in mice via sympathetic post-ganglionic neurons, while high-frequency EA suppression is mediated by the sympathoadrenal medullary axis. Brain Research Bulletin, vol. 75, no. 5, pp. 698–705, 2008.

(18) B Kavoussi B, Ross BE. The neuroimmune basis of anti-inflammatory acupuncture. Integrative Cancer Therapies, vol. 6, no. 3, pp. 251–257, 2007.

(19) Pfab F, Hammes M, Backer M et al. Preventive effect of ¨ acupuncture on histamine-induced itch: a blinded, randomized, placebo-controlled, crossover trial. Journal of Allergy and Clinical Immunology, vol. 116, no. 6, pp. 1386–1388, 2005.

(20) Pfab F, Huss-Marp J, Gatti A et al. Influence of acupuncture on type i hypersensitivity itch and the wheal and flare response in adults with atopic eczema—a blinded, randomized, placebo controlled, crossover trial. Allergy, vol. 65, no. 7, pp. 903–910, 2010.

(21) Joos S, Schott C, Zou H, Daniel V, Martin E. Immunomodulatory effects of acupuncture in the treatment of allergic asthma: a randomized controlled study. Journal of Alternative and Complementary Medicine, vol. 6, no. 6, pp. 519– 525, 2000.

(22) Fang JQ, Liu F, Shao XM, Wu YY. Effect of electroacupuncture on carrageenan-induced inflammation, IL-1beta and TNF-alpha concentrations and their mRNA expressions in toe tissue in rats. Zhen Ci Yan Jiu, vol. 32, no. 4, pp. 224–228, 2007.

(23) Li YM, Zhuang LX, Lai XS, Jiang GH. Effects of electroacupuncture on plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients. Zhen Ci Yan Jiu, vol. 32, no. 2, pp. 136–138, 2007.

(24) Mori H, Nishijo K, Kawamura H, Abo T. Unique immunomodulation by electro-acupuncture in humans possibly via stimulation of the autonomic nervous system. Neurosci. Lett. 320, 21–24, 2002.

(25) Han J.S. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci. 26, 17–22, 2003.

(26) Chiu JH, Cheng HC, Tai CH, et al. Electroacupuncture-induced neural activation detected by use of manganese-enhanced functional magnetic resonance imaging in rabbits. Am. J. Vet. Res. 62, 178–182, 2001.

(27) Hsieh JC, Tu CH, Chen FP, et al. Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study. Neurosci. Lett. 307, 105–108, 2001.

(28) Yu Y, Kasahara T, Sato T, et al. Enhancement of splenic interferon-gamma, interleukin-2, and NK cytotoxicity by S36 acupoint acupuncture in F344 rats. Jpn. J. Physiol. 47, 173–178, 1997.

(29) Hisamitsu T, Kasahara T, Umezawa T, Ishino T, Hisamitsu, T. The effect of acupuncture on natural killer cell activity. Int. Cong. Ser. 1238, 125–131, 2002.

(30) Kowalski J. Effect of enkephalins and endorphins on cytotoxic activity of natural killer cells and macrophage/monocytes in mice. Eur. J. Pharmacol. 326, 251–255, 1997.

(31) Kim CK, Choi GS, Oh SD, et al. Electroacupuncture up-regulates natural killer cell activity: identification of genes altering their expressions in electroacupuncture induced up-regulation of natural killer cell activity. J. Neuroimmunol. 168, 144–153, 2005.

(32) Lee Y, Kim SK, Kim Y, et al. The α-adrenoceptor mediation of the immunomodulatory effects of electroacupuncture in DNP-KLH immunized mice. Neurosci. Lett. 423, 149–152, 2007.

(33) Rho SW, Choi GS, Ko EJ, et al. Molecular changes in remote tissues induced by electro-acupuncture stimulation at acupoint ST36. Mol. Cells 25, 178–183, 2008.

(34) Abbas AK, Murphy KM, Sher A, 1996. Functional diversity of helper T lymphocytes. Nature 383, 787–793, 1996.

(35) Romagnani S. The Th1/Th2 paradigm. Immunol Today. Jun;18(6):263-6, 1997.

(36) Lohr J, Knoechel B, Caretto D, Abbas AK. Balance of Th1 and Th17 effector and peripheral regulatory T cells. Microbes Infect. 11(5):589-93, 2009.

(37) Maggi, E. The Th1/Th2 paradigm in allergy. Immunotechnology. 3(4):233-44, 1998.

(38) Kim SK, Bae H. Acupuncture and immune modulation. Auton Neurosci. 157(1-2):38-41, 2010.

(39) Park MB, Ko E, Ahn C, et al. Suppression of IgE production and modulation of Th1/Th2 cell response by electroacupuncture in DNP-KLH immunized mice. J. Neuroimmunol. 151, 40–44, 2004.

(40) Wang R, Jiang C, Lei Z, Yin K. The role of different therapeutic courses in treating 47 cases of rheumatoid arthritis with acupuncture. J. Tradit. Chin. Med. 27, 103–105, 2007.

(41) Lee H, Lee JY, Kim YJ, et al. Acupuncture for symptom management of rheumatoid arthritis: a pilot study. Clin. Rheumatol. 27, 641–645, 2008.

(42) Aoki E, Kasahara T, Hagiwara H, Sunaga M, Hisamitsu N, Hisamitsu T. Electroacupuncture and moxibustion influence the lipopolysaccharide-induced TNF-alpha production by macrophages. In Vivo 19, 495–5, 2005.

(43) Bao CH, Zhao JM, Liu HR et al. Randomized controlled trial: moxibustion and acupuncture for the treatment of Crohn’s disease. World Journal of Gastroenterology, vol. 20, no. 31, pp. 11000–11011, 2014.

(44) Zhao C, Bao C, Li J, et al. Moxibustion and Acupuncture Ameliorate Crohn's Disease by Regulating the Balance between Th17 and Treg Cells in the Intestinal Mucosa. Evid Based Complement Alternat Med. 2015:938054, 2015.

(45) Moretta A, Biassoni R, Bottino C, Mingari MC, Moretta L. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis. Immunol Today. 21(5):228-34, 2000.

(46) Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol. 9(5):503-10, 2008.

(47) Zwirner NW, Domaica CI, Fuertes MB. Regulatory functions of NK cells during infections and cancer. J Leukoc Biol. 109(1):185-194, 2021.

(48) Morandi B, Mortara L, Chiossone L, et al. Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response. PLoS One. 7(6):e39170, 2012.

(49) Morandi B, Mortara L, Carrega P, et al. NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs. Int Immunol. 21(5):599-606, 2009.

(50) Chiossone L, Dumas PY, Vienne M, Vivier E. Natural killer cells and other innate lymphoid cells in cancer. Nat Rev Immunol. 18(11):671-688, 2018.

(51) Bruno A, Focaccetti C, Pagani A, et al. The proangiogenic phenotype of natural killer cells in patients with non-small cell lung cancer. Neoplasia. 15(2):133-42, 2013.

(52) Bosi A, Zanellato S, Bassani B, et al. Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization. J Immunol Res. 2018:2438598, 2018.

(53) Gallazzi M, Baci D, Mortara L, et al. Prostate Cancer Peripheral Blood NK Cells Show Enhanced CD9, CD49a, CXCR4, CXCL8, MMP-9 Production and Secrete Monocyte-Recruiting and Polarizing Factors. Front Immunol. 2021 Jan 25;11:586126.

(54) Morandi B, Bramanti P, Bonaccorsi I, et al. Role of natural killer cells in the pathogenesis and progression of multiple sclerosis. Pharmacol Res. 57(1):1-5, 2008.

(55) Gallo D, Piantanida E, Gallazzi M, et al. Immunological Drivers in Graves' Disease: NK Cells as a Master Switcher. Front Endocrinol (Lausanne). 11:406, 2020.

(56) Sato T, Yu Y, Guo SY, Kasahara T, Hisamitsu T. Acupuncture stimulation enhances splenic natural killer cell cytotoxicity in rats. Jpn. J. Physiol. 46, 131–136, 1996.

(57) Choi GS, Oh SD, Han JB. Modulation of natural killer cell activity affected by electroacupuncture through lateral hypothalamic area in rats. Neurosci. Lett. 329, 1–4, 2002.

(58) Yamaguchi N, Takahashi T, Sakuma M. Acupuncture regulates leukocyte subpopulations in human peripheral blood. Evid. Based Complement. Alternat. Med. 4, 447–453, 2007.







How to Cite

Mortara L, Coco G, Pozzi C. Biomedicine and traditional Chinese medicine: a fruitful scientific and cultural interaction. Acta Biomed [Internet]. 2022 Mar. 14 [cited 2024 Jul. 21];93(1):e2022070. Available from: