A randomized controlled trial (RCT) to explore the effect of audio-visual entrainment among psychological disorders.: Neuro-Upper

A randomized controlled trial (RCT) to explore the effect of audio-visual entrainment among psychological disorders.

Neuro-Upper

Authors

Keywords:

Entrainment, Brain-Computer-Interface, Psychological disorders, Intervention

Abstract

Background and aim: Although many mental disorders have relevant proud in neurobiological dysfunctions, most intervention approaches neglect neurophysiological features or use pharmacological intervention alone. Non-invasive Brain-Computer Interfaces (BCIs), providing natural ways of modulating mood states, can be promoted as an alternative intervention to cope with neurobiological dysfunction.

Methods: A BCI prototype was proposed to feedback a person’s affective state such that a closed-loop interaction between the participant’s brain responses and the musical stimuli is established. It feedbacks in real-time flickering lights matching with the individual’s brain rhythms undergo to auditory stimuli. A RCT was carried out on 15 individuals of both genders (mean age = 49.27 years) with anxiety and depressive spectrum disorders randomly assigned to 2 groups (experimental vs. active control).

Results: Outcome measures revealed either a significant decrease in Hamilton Rating Scale for Depression (HAM-D) scores and gains in cognitive functions only for participants who undergone to the experimental treatment. Variability in HAM-D scores seems explained by the changes in beta 1, beta 2 and delta bands. Conversely, the rise in cognitive function scores appear associated with theta variations.

Conclusions: Future work needs to validate the relationship proposed here between music and brain responses. Findings of the present study provided support to a range of research examining BCI brain modulation and contributes to the understanding of this technique as instruments to alternative therapies We believe that Neuro-Upper can be used as an effective new tool for investigating affective responses, and emotion regulation (www.actabiomedica.it)

Author Biography

Olimpia Pino, University of Parma, Department of Medicine & Surgery, Neuroscience Unit

Department of Medicince and Surgery, Neuroscience Unit

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Published

19-01-2022

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ORIGINAL ARTICLES

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1.
Pino O. A randomized controlled trial (RCT) to explore the effect of audio-visual entrainment among psychological disorders.: Neuro-Upper. Acta Biomed [Internet]. 2022 Jan. 19 [cited 2024 Jul. 13];92(6):e2021408. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/12089