The Evaluation of End Tidal Carbon Dioxide Values in Intubated Patients with COVID-19: End Tidal Carbon Dioxide and COVID-19

The Evaluation of End Tidal Carbon Dioxide Values in Intubated Patients with COVID-19

End Tidal Carbon Dioxide and COVID-19


  • Rezan Karaali
  • Adem Çakır
  • Ejder Saylav Bora a:1:{s:5:"en_US";s:49:"İZMİR ATATURK RESEARCH AND TRAİNİNG HOSPİTAL";}
  • Pınar Yeşim Akyol
  • Cemil Kavalcı
  • Hüseyin Acar


capnography, COVID-19, Emergency, intubation


Background: The aim of this study is to establish the value of PETCO2 in COVID-19 patients intubated in emergency department, and its effects on mortality. 

Objectives: Between May 15, 2020 and January 15, 2021, The patients aged ≥18 years and diagnosed COVID-19, scheduled for urgent intubation in the emergency department were included.

Method: Single-center, prospective and observational study. Age, gender, vital signs, laboratory findings are recorded. Immediately after intubation as measured by the capnography, the initial PETCO2_1 and at post-ventilation 15 min, PETCO2_2 and first, second arterial blood gas analysis are recorded.

Results: The mean age of the 48 patients was 74 years. The PETCO2_1 and PETCO2_2 measurements were statistically significantly different between the patients who survived and those who died (p=0.014, p=0.015). The patients with a high first PETCO2_1 value and a decrease to the normal level survived, but those with a low PETCO2_1 value that could not increase to a normal value died (p=0.038, p=0.031). Increased levels of SpO2, PETCO2_1, PETCO2_2 and PaCO2_2 decreased the risk of mortality, while an increased level of PaO2_2 increased the risk of mortality.

Conclusion: Capnography is non-invasive and provides continuous measurement. Assessment of changes in PETCO2 value would contribute to patient survival.


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How to Cite

Karaali R, Çakır A, Bora ES, Akyol PY, Kavalcı C, Acar H. The Evaluation of End Tidal Carbon Dioxide Values in Intubated Patients with COVID-19: End Tidal Carbon Dioxide and COVID-19. Acta Biomed [Internet]. 2022 Mar. 14 [cited 2024 Jul. 21];93(1):e2022032. Available from: